Khachiyan was born and raised in New Jersey, the daughter of the late Russian mathematician and Rutgers University Professor Leonid Khachiyan.
Khachiyan co-hosts the Red Scare podcast with actor Dasha Nekrasova . Together, they critique neoliberalism and feminism that is both comedic and serious in tone, while also covering current topics in American culture and politics .
The show has been associated with the "dirtbag left" of Brooklyn. Several notable celebrities, artists, politicians, and cultural commentators have appeared on Red Scare, including Natasha Stagg, Juliana Huxtable, Tulsi Gabbard, Caroline Calloway, Angela Nagle, Ross Douthat, and Ariana Reines. 
Khachiyan has appeared on The Portal, a podcast by Eric Weinstein.
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