Craniofacial Developmental Biology Laboratory
Craniofacial Developmental Biology Laboratory | |
|---|---|
| Established | 2008 |
| Research Type | The lab researches facial morphogenesis and development to turn scientific discoveries into clinical advancements |
| Field of research | Developmental Biology, Genetics, Cleft Lip and Cleft Palate, Cranial Neural Crest Biology, Wnt Signaling |
| Director | Dr. Eric C. Liao, MD, Ph.D |
| Affiliations | Massachusetts General Hospital, Harvard Medical School |
| Website | http://www.massgeneral.org/plasticsurgery/research/researchlab.aspx?id=1346 |
Overview[edit]
The Craniofacial Developmental Biology Laboratory, also known as the Liao Lab, works toward better understanding the developmental genetics behind facial morphogenesis. Located at the Center for Regenerative Medicine at Massachusetts General Hospital, the laboratory performs research on the developing palate and neural crest cells to better understand the genetics behind facial development. By using the zebrafish model, the lab can take advantage of the forward and reverse genetics of the organism while still retaining many of the same genes present in humans as well as the same coordination of complex molecular and morphogenic cues.[1] Furthermore, the zebrafish palate (ethmoid plate) is morphogenetically homologous to the mammalian primary palate.[2]
The principal investigator of the Craniofacial Developmental Biology Laboratory is Dr. Eric C. Liao, MD, Ph.D. Dr. Liao graduated from Stanford University (B.S., M.S.), and Harvard Medical School / M.I.T (M.D., Ph.D.). He trained in plastic surgery at Massachusetts General Hospital and is board certified by the American Board of Plastic Surgery. Dr. Liao is an associate professor of surgery at Harvard Medical School, a principal faculty member and a principal investigator at the Harvard Stem Cell Institute, and the Deputy Director of Research at Boston Shriners Hospital.[3] As a surgeon, Dr. Liao focuses in both cosmetic and reconstructive surgery. Dr. Liao has researched and published about patient safety, such as the prevention of deep vein thrombosis in breast reconstruction patients.[4] Dr. Liao commonly performs human cleft reconstructive surgery and, through his lab, has reproduced the pathology of oblique facial clefts in the zebrafish model.[5] For the Cleft and Craniofacial awareness month at Shriner's Hospital for Children in July 2017, Laney's Story[6] and Penny's Story[7] were featured and are both Dr. Liao's patients.
Group Members[edit]
Principal Investigator: Eric C. Liao, MD, Ph.D
Research Fellows:
- Kana Ishii, MD, Ph.D
- Kusumika Mukherjee, Ph.D
- Robert Shore, Ph.D
Students:
- Edward Li, MD, Ph.D candidate, Harvard Medical School – MIT
- Dawn Truong, Harvard College
- Nikhil Sobti, Boston University School of Medicne
- William Misciagna, Belmont Hill School
- Alexi Monovoukas, Phillips Exeter Academy
Lab Manager:
- Megan Rebello, BS
Lab Technicians:
- Shawn Hallett, BS
Aquatics Facility Manager
- Renee Ethier, BS
Clinical Research Coordinator:
- Rebecca Lynne Steven Brown, BS
References[edit]
This article "Craniofacial Developmental Biology Laboratory" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Craniofacial Developmental Biology Laboratory. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
- ↑ "Craniofacial Developmental Biology Laboratory." Massachusetts General Hospital, The General Hospital Corporation, www.massgeneral.org/plasticsurgery/research/researchlab.aspx?id=1346. Accessed 17 July 2017.
- ↑ Dougherty, M., et al. "Distinct requirements for wnt9a and irf6 in extension and integration mechanisms during zebrafish palate morphogenesis." PubMed, 15 Nov. 2012, www.ncbi.nlm.nih.gov/pubmed/23154410. Accessed 17 July 2017.
- ↑ "Chien-Wei (Eric) Liao, MD, PhD." Harvard Stem Cell Institute, Harvard College, hsci.harvard.edu/people/chien-wei-eric-liao-md-phd. Accessed 17 July 2017.
- ↑ "Liao, Chien-Wei Eric, MD, PhD." Massachusetts General Hospital, The General Hospital Corperation, www.massgeneral.org/doctors/doctor.aspx?id=17478. Accessed 17 July 2017.
- ↑ "Closing the Genetic Gap in Orofacial Clefts." MassGeneral Hospital for Children, The General Hospital Corporation, 1 Jan. 2016, www.massgeneral.org/children/news/newsarticle.aspx?id=5637. Accessed 17 July 2017.
- ↑ Cleft and Craniofacial Awareness Month Laney's story." Shriners Hospitals for Children, 11 July 2017, www.shrinershospitalsforchildren.org/news/ Accessed 25 July 2017].
- ↑ "Cleft and Craniofacial Awareness Month - Penny's story." Shriners Hospitals for Children, 30 June 2017, www.shrinershospitalsforchildren.org/news/ Accessed 25 July 2017.
