Genetic Links to Anxiety and Depression Study
The Genetic Links to Anxiety and Depression (GLAD) Study is a project set up to explore the genetic risk factors in individuals who have experienced depression and/or anxiety now or in the past. The study launched in September 2018, initially rolling out in England with the aim to recruit at least 40,000 people who have experienced either anxiety and/or depression at some point in their lives. The study is led by Dr Gerome Breen and Professor Thalia Eley at King’s College London and the National Institute of Health Research (NIHR) BioResource Centre Maudsley, as part of the NIHR BioResource for Translational Research.
Research Topic[edit]
Anxiety and depression are extremely common in society and have a significant impact on quality of life. In the UK, 1 in 6 people have reported depression or anxiety in the past year and 1 in 3 will experience symptoms during their lifetime.[1] Whilst psychological therapy, antidepressants and anti-anxiety drug treatments are more available than ever before, only around half of those treated respond well.[2] It is the aim of the study to develop a better understanding of mental health genetics, in order to enable the development of new and more effective treatment options and to help predict which treatments work for specific types of patients.
Research has found that 30-40% of depression and anxiety risk is genetic and so far, over 40 genetic links to depression and anxiety have been identified.[3][4][5][6] In order to investigate and understand depression and anxiety, a very large group of patients and detailed information on their symptoms are needed.
Study Aims[edit]
The GLAD Study aims to explore:
- The genetic predictors of depression and anxiety disorders.
- The environmental risk factors, comorbid disorders and their association with depression and anxiety severity.
- Responses to treatment and severity of disorders based on genetic information.
- Gene-environment interactions to improve our understanding of the disorders themselves.
The data collected by the GLAD Study is available to researchers outside the study group who wish to explore the role of genetic and environmental factors in the development of depression and anxiety disorders. Participants who take part in the study will also be able take part in other similar research studies. The GLAD Study is recruiting anyone who has experienced clinical depression and/or anxiety during their life, is 16 or above and lives in England, via online questionnaires and postal DNA sampling.
National Institute of Health Research (NIHR) BioResource[edit]
Everyone who signs up to the GLAD Study joins the NIHR Mental Health BioResource. The NIHR Mental Health BioResource is a branch of the NIHR BioResource, which aims to increase participation of people with mental health disorders in medical and psychological research. The NIHR BioResource is a large biorepository of >100,000 volunteers from the general population and patients with common and rare diseases who have consented to be contacted about research studies investigating the link between genes, the environment, health, and disease.
Media[edit]
http://www.londonlive.co.uk/news/2018-09-18/largest-study-into-depression-and-anxiety-launched
External Links[edit]
National Institute of Health Research (NIHR) BioResource Centre Maudsley
NIHR BioResource for Translational Research.
References[edit]
- ↑ "Adult Psychiatric Morbidity Survey: Survey of Mental Health and Wellbeing, England, 2014 - NHS Digital". NHS Digital. Retrieved 2018-09-25.
- ↑ "NHS Digital, Psychological Therapies: Annual report on the use of IAPT services England, 2016-17, February 2018" (PDF).
- ↑ Hettema, John M.; Neale, Michael C.; Kendler, Kenneth S. (October 2001). "A Review and Meta-Analysis of the Genetic Epidemiology of Anxiety Disorders". American Journal of Psychiatry. 158 (10): 1568–1578. doi:10.1176/appi.ajp.158.10.1568. ISSN 0002-953X. PMID 11578982.
- ↑ Sullivan, Patrick F.; Neale, Michael C.; Kendler, Kenneth S. (October 2000). "Genetic Epidemiology of Major Depression: Review and Meta-Analysis". American Journal of Psychiatry. 157 (10): 1552–1562. doi:10.1176/appi.ajp.157.10.1552. ISSN 0002-953X. PMID 11007705.
- ↑ Purves, Kirstin Lee; Coleman, Jonathan R. I.; Rayner, Christopher; Hettema, John M.; Deckert, Jürgen; McIntosh, Andrew M.; Nicodemus, Kristin K.; Breen, Gerome; Eley, Thalia C. (2017-10-16). "The Common Genetic Architecture of Anxiety Disorders". BioRxiv: 203844. doi:10.1101/203844.
- ↑ Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, Tracy M. (2018-04-26). "Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression". Nature Genetics. 50 (5): 668–681. doi:10.1038/s41588-018-0090-3. ISSN 1061-4036. PMC 5934326. PMID 29700475.
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