Jesper Svejstrup
Jesper Qualmann Svejstrup (born March 28, 1963)[citation needed] is a Danish molecular biologist and biochemist, recognized[by whom?] for his expertise in the study of gene transcription and its intricate relationship with DNA-related processes including DNA repair, replication, and recombination.[1] Svejstrup is a member of the European Research Council and has made significant contributions to the field of molecular biology.[2][3]
Early life & education[edit]
Jesper Qualmann Svejstrup was born on March 28th, 1963, in Aarhus, Denmark, to parents who worked as building engineers. Following the completion of his secondary education, Svejstrup attended Aarhus University where he earned a degree in biology in 1989. He then continued his studies at the same institution, earning his PhD in molecular biology.[2][3]
Research & career[edit]
During his doctoral studies, Jesper Qualmann Svejstrup conducted research on the molecular mechanism of DNA Topoisomerases, which are enzymes that help eliminate overwinding or underwinding of DNA. His investigations led him to the discovery of 'suicide substrates' for DNA topoisomerase I and the realization that the anti-tumor drug camptothecin blocks the enzyme's re-ligation reaction.[4][5][6] After receiving his doctorate in 1993, Svejstrup moved to Stanford University as a Postdoctoral researcher in the group led by Roger D. Kornberg. At Stanford, Svejstrup focused on studying the general transcription factor TFIIH and the Mediator complex.[7] In 1996, Svejstrup relocated to the United Kingdom to establish his research group at Clare Hall Laboratories, which was supported by the Imperial Cancer Research Fund, later renamed Cancer Research UK. His laboratory's research continued to focus on gene transcription and its associated factors. In 2016, Svejstrup's laboratory moved to the Francis Crick Institute located in London.
Jesper Qualmann Svejstrup currently holds the position of a professor and Deputy Head of Research at the Department of Cellular and Molecular Medicine at the University of Copenhagen. He is also a Visiting Scientist at the Francis Crick Institute in London. Additionally, Svejstrup holds the positions of Honorary Professor at University College London and Imperial College London, and Honorary Skou Professor at Aarhus University.[8]
Svejstrup's research group specializes in studying the fundamental mechanisms of RNA polymerase II transcription. They have a specific focus on transcript elongation and the interface with processes that help maintain genome stability. His research aims to unlock a deeper understanding of the complex interactions between transcription factors, DNA, and RNA polymerase II, and how these interactions can impact the stability of the genome.[9]
Awards & honors[edit]
Jesper Qualmann Svejstrup has been appointed as a member of several esteemed organizations throughout his career. In 2003, he was appointed as a member of the European Molecular Biology Organization (EMBO), followed by his appointment as a Fellow of the Royal Society in 2009. In 2016, he was honored as a Foreign Member of the Royal Danish Academy of Sciences and Letters, and in 2018, he was elected as a Fellow of the Academy of Medical Sciences (United Kingdom).[10]
Presently, he serves on the Scientific Council of the European Research Council, a distinguished position that is a testament to his expertise and significant contributions to the field of molecular biology.[11]
Publications[edit]
- Jesper Q Svejstrup. "Contending with transcriptional arrest during RNAPII transcript elongation". Trends in biochemical sciences.[12]
- Jesper Q Svejstrup. "The interface between transcription and mechanisms maintaining genome integrity". Trends in biochemical sciences.[13]
- Jesper Q Svejstrup, Zhigang Wang, William J Feave, Xiahua Wu, David A Bushnell, Thomas F Donahue, Errol C Friedberg, Roger D Kornberg. "Different forms of TFIIH for transcription and DNA repair: holo-TFIIH and a nucleotide excision repair some". Cell.[14]
- Jesper Q Svejstrup, Kent Christiansen, Irina I Gromova, Anni H Andersen, Ole Westergaard. "New technique for uncoupling the cleavage and religation reactions of Eukaryotic Topoisomerase I.: The mode of action of camptothecin at a specific recognition site". Journal of molecular biology.[15]
- Jesper Q Svejstrup. "The RNA polymerase II transcription cycle: cycling through chromatin". Biochimica Et Biophysica Acta (BBA)-Gene Structure and Expression.[16]
References[edit]
- ↑ "Jesper Svejstrup". erc.europa.eu. Retrieved 2022-12-12.
- ↑ 2.0 2.1 Copenhagen, University of (2007-04-26). "Result". research.ku.dk. Retrieved 2022-12-12.
- ↑ 3.0 3.1 "Professor Jesper Svejstrup | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2022-12-12.
- ↑ Svejstrup, Jesper Q.; Christiansen, Kent; Gromova, Irina I.; Andersen, Anni H.; Westergaard, Ole (1991-12-05). "New technique for uncoupling the cleavage and religation reactions of Eukaryotic Topoisomerase I.: The mode of action of camptothecin at a specific recognition site". Journal of Molecular Biology. 222 (3): 669–678. doi:10.1016/0022-2836(91)90503-X. ISSN 0022-2836.
- ↑ Friedberg, Errol C.; Bardwell, A. Jane; Bardwell, Lee; Feaver, William J.; Kornberg, Roger D; Svejstrup, Jesper Qualmann; Tomkinson, Alan E.; Wang, Zhigang; Lindahl, Tomas Robert; West, Stephen Craig (1995-01-30). "Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription". Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 347 (1319): 63–68. doi:10.1098/rstb.1995.0010.
- ↑ Kjeldsen, Eigil; Svejstrup, Jesper Q.; Gromova, Irina I.; Alsner, Jan; Westergaard, Ole (1992-12-20). "Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I". Journal of Molecular Biology. 228 (4): 1025–1030. doi:10.1016/0022-2836(92)90310-G. ISSN 0022-2836.
- ↑ "transcription factors chromatin: Topics by WorldWideScience.org". worldwidescience.org. Retrieved 2022-12-12.
- ↑ "cordis.europa.eu".
- ↑ "Transcription and the maintenance of genome integrity - Dimensions". app.dimensions.ai. Retrieved 2022-12-12.
- ↑ "Professor Jesper Svejstrup | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2022-12-12.
- ↑ "Distinguished scientists and scholars to join the ERC Scientific Council". erc.europa.eu. Retrieved 2022-12-12.
- ↑ Svejstrup, Jesper Q. (2007-04-01). "Contending with transcriptional arrest during RNAPII transcript elongation". Trends in Biochemical Sciences. 32 (4): 165–171. doi:10.1016/j.tibs.2007.02.005. ISSN 0968-0004.
- ↑ Svejstrup, Jesper Q. (2010-06-01). "The interface between transcription and mechanisms maintaining genome integrity". Trends in Biochemical Sciences. 35 (6): 333–338. doi:10.1016/j.tibs.2010.02.001. ISSN 0968-0004. PMID 20194025.
- ↑ Svejstrup, Jesper Q; Wang, Zhigang; Feave, William J; Wu, Xiahua; Bushnell, David A; Donahue, Thomas F; Friedberg, Errol C; Kornberg, Roger D (January 1995). "Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome". Cell. 80 (1): 21–28. doi:10.1016/0092-8674(95)90447-6. ISSN 0092-8674.
- ↑ Svejstrup, Jesper Q.; Christiansen, Kent; Gromova, Irina I.; Andersen, Anni H.; Westergaard, Ole (1991-12-05). "New technique for uncoupling the cleavage and religation reactions of Eukaryotic Topoisomerase I.: The mode of action of camptothecin at a specific recognition site". Journal of Molecular Biology. 222 (3): 669–678. doi:10.1016/0022-2836(91)90503-X. ISSN 0022-2836.
- ↑ Svejstrup, Jesper Q. (2004-03-15). "The RNA polymerase II transcription cycle: cycling through chromatin". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. Chromatin structure and function. 1677 (1): 64–73. doi:10.1016/j.bbaexp.2003.10.012. ISSN 0167-4781.
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