Laurent Schwartz (oncologist)
|Born||October 6, 1958|
Laurent Schwartz is a french oncologist born 1958 in Strasbourg (France)
It is of Alsatian origin from a family of intellectuals imbued with scientific and medical culture. His father was Dean of the Faculty of medicine. It is a distant cousin of the mathematician Laurent Schwartz and the pediatrician Robert Debré.
After medical studies in his hometown, Laurent Schwartz left for the United States. He was researcher at the National Cancer Institute then resident at the Massachusetts General Hospital (Harvard University), where he specialized in radiation oncology. He returned to France in 1990 where he was recruited by the Assistance Publique des Hôpitaux de Paris as a staff radiation therapist (1993).
The limited clinical results of the war against cancer
Laurent Schwartz was among the first oncologist to state the lack of results of modern Oncology. In developed countries, the cause of death is registered in the death certificate. These data are tabulated by the various countries then centralized by the International Agency for Research on Cancer (IARC), based in Lyon (France). With the help of the mathematician Mireille Summa, of the University of Paris – Dauphine, Laurent Schwartz analyzes the evolution of cancer mortality. They demonstrate that Standardized age cancer mortality declined by only 13% between 1960 and 2013 . In developping countries, breast cancer mortality is similar to that of 1960. This finding is supported by a publication of John Bailar in the prestigious New England Journal of Medicine (Cancer undefeated) .
Rewrite the cancer by physics
In order to find a cure for cancer, Laurent Schwartz's brings together physicists, mathematicians, biologists and physicians to rethink this disease. The idea is that the laws of physics apply also to biology and medicine. Every disease can be explained by physics. These scientists wrote a table of Mendeleev of diseases. Biology and medicine can be read by the interaction of physical forces with the living ,. Every disease can be summarized by a change in pressure and/or electromagnetic yield .
Schwartz has demonstrated that
- Inflammation and increased osmotic pressure are synonymous. Regardless of the causal agent of inflammation (insect bite, chemical insult or even burning), there is leakage in the extracellular fluid of an abnormally high amount of proteins. These proteins increase the osmotic pressure. Every symptom such as seen in inflammation can be explained by this increased osmotic pressure. It is the first time that a disease can be explained by a change in physical parameter, in this case pressure .
- Cancer can be summarized by the Warburg effect. Cell proliferation, increased pressure and metastasis are the direct consequences of the defective mitochondria ,. The activation of the immune system such as seen in inflammation of cancer is also a direct consequence of increased pressure.
- The toxicity of tobacco is caused by inhalation of large quantities of carbon dioxide. The concentration of CO2 is 500 times more important in smoke than in ambient air. Inhalation of CO2 by the smoker alters cellular respiration and causes lung inflammation .
- Alzheimer's disease and Parkinson's disease are the result of increased pressure in the brain parenchyma secondary to the shock wave itself a consequence of the heartbeat.
- An increase in pressure is responsible for the secretion of amyloid, synuclein or the phosphorylation of tau protein ,.
- The blood flow explains the morphogenesis of the blood vessel and the heart ,.
- The cell cycle is explained by physics .
Treatment of cancer
Cancer is summarized by the Warburg effect, ie by the drop in energy yield. During carcinogenesis, the mitochondrion is disconnected from the cytoplasm. Performance of the mitochondria, the cell's power plant, collapses, resulting in increased glucose upatake. Metabolic treatment of cancer is intended to switch mitochondria back on in order to burn the residues of glucose and arrest tumor growth ,. There are many drugs or dietary supplements that target the cell metabolism and raise the mitochondrial activity (2-deoxy-glucose, bromo-pyruvate, resveratrol., lipoic acid) Laurent Schwartz has tested over a hundred of these drugs. A combination of lipoic acid (activator of pyruvate desydrogenase) and hydroxycitrate (citrate lyase inhibitor) leads a stabilization of tumors implanted in mice ,.Recently, other potentially active molecules have been reported such as chlorine dioxide and methylene blue. All these molecules have a common feature, they reset the mitochondrial activity and thus block the proliferation of cancer cells.
Emergence of new players
The survival time of a patient with metatstatic disease is short. He does not have the time to wait for lenghty clinical trials. Patients are trying unproven medecine to improve their survival rate. Many patients have tested the metabolic approach to cancer. This treatment is an adjunct to chemotherapy treatment. Hundreds of patients report their experience, for the most part positive, in a dedicated website (https://guerir-du-cancer.fr/). Laurent Schwartz would like that standardized tests confirm (or infirm) these results. The metabolic treatment is probably a turning point in the treatment of cancer.
Toward a drastic simplification of medicine
One of schwartz’s key hypothesis is the fact that cancer and alzheimer’s diseases share a lot in common. The epidemiological features are similar. To the exception of the rare cases of infantile cancer and Alzheimer among young adults, both diseases are prevalent among the elderly. In both cases chronic inflammation is a key risk factor. Least but not last, the mitochondria are defective. In cancer, the mitochondrial defects are responsible of the Warburg’s effect and relenting growth. In Alzheimer’s disease, the mitochondrial defect appears key to apoptosis and cell death. It is possible that one day the treatment (increasing mitochondrial energy yield) may be similar.
- Métastases : vérités sur le cancer. 1998 Hachette.
- Cancer-Between Glycolysis and Physical Constraint: Between Glycolysis and Physical Constraint. 2004 Springer Science.
- Cancer: A Dysmethylation Syndrome? 2005 John Libbey Eurotext. (with Maurice Israel)
- Le principe de vie 2007 La Martinière
- Cancer guérir tous les malades 2013 Hugo doc
- Cancer un traitement simple et non toxique 2016 Thierry Souccar
- La fin des maladies ? 2018 Les liens qui libèrent
- Cancer : la piste oubliée [archive] Arte Science 2015
- Cancer, la piste oubliée (Arte) - Un espoir contre la maladie [archive] Télé 7 jours 2015
- La piste nouvelle du Dr Schwartz pour guérir simplement le cancer [archive] Reporterre 2017
- Vers une alimentation VRAIMENT anticancer ? [archive] La lettre du Dr Rueff 2019
- Naturopathie : Conférence du Dr Laurent Schwartz [archive] Radio Mélodie
- Conférence biomédicale du Dr. Laurent Schwartz [archive] Université de Tours
- "La fin des maladies", du docteur Laurent Schwartz [archive] Europe 1
- Laurent Schwartz cancérologue [archive] Les savanturiers France Inter 2013
- Les meilleurs extraits du livre du Dr Laurent Schwartz [archive] Alternative Santé 2016
- Cancer: Vous avez interviewé le cancérologue Laurent Schwartz [archive] 20minute.fr 2013
- Dr Laurent Schwartz : "Le cancer appartiendra bientôt au passé" [archive] Medisite 2017
- Laurent Schwartz repense l'approche du cancer [archive] Radio Télévision Suisse 2013
- Cancer, guérir tous les malades? – Dr Laurent Schwartz [archive] EspaceSante Canada 2020
- Conférence-débat sur le cancer avec le docteur Laurent Schwartz [archive] DNA 2018
- Cancer : le jeûne en complément du traitement ? [archive] Le Figaro Santé 2017
- Un docteur pas ordinaire [archive] Le Devoir 2017
- Gettler-Summa, M., Goldfarb, B., Schwartz, L., Scott, Jj. M., Lefaudeux, F. (2010). Modeling of multiple and multidimensional time series. Revue MODULAD, 85(42)
- Bailar, J. C., Gornik, H. L. (1997). Cancer undefeated. New England Journal of Medicine, 336(22), 1569-1574
- Schwartz, L. (1998). Métastases: vérités sur le cancer. Hachette littératures.
- Schwartz, L., Lafitte, O., da Veiga Moreira, J. (2018). Toward a Reasoned Classification of Diseases Using Physical-Chemical Based Phenotypes. Frontiers in physiology, 9, 94
- Schwartz, L., Guais, A., Pooya, M., Abolhassani, M. (2009). Inflammation is a consequence of extracellular hyperosmolarity? Journal of inflammation, 6(1), 21.
- Schwartz, L., Supuran, T Alfarouk, K (2017). The Warburg effect and the hallmarks of cancer. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 17(2), 164-170
- Israel, M., Schwartz, L. (2011). The metabolic advantage of tumor cells. Molecular cancer, 10(1), 70.
- Schwartz, L., Guais, A., Chaumet-Riffaud, P., Grevillot, G., Sasco, A. J., Molina, T. J., Abolhassani, M. (2010). Carbon dioxide is largely responsible for the acute anti-inflammatory effects of tobacco smoke. Inhalation toxicology, 22(7), 543-551
- Levy Nogueira, M., da Veiga Moreira, j., Baronzio, G. F., Dubois, b., Scott, J. M., Schwartz, l. (2015). Mechanical stress as the common denominator between chronic inflammation, cancer, and Alzheimer's disease. Frontiers in oncology, 5, 197
- Nogueira, M. L., Hamraz, M., Abolhassani, M., Bigan, E., Lafitte, O., Steyaert, J. M., Schwartz, L. (2018). Mechanical stress increases brain amyloid β, tau, and α-synuclein concentrations in wild-type mice. Alzheimer's & Dementia, 14(4), 444-453.
- Fleury, V.,Schwartz, L. (1999). Diffusion limited aggregation from shear stress as a simple model of vasculogenesis. Fractals, 7(01), 33-39.
- Fleury, V., Schwartz, L. (2000). Modelisation of 3-D microvasculature by interlaced diffusion limited aggregation. Fractals, 8(03), 255-259.
- Da Veiga, J., Lafitte, O., Schwartz, L. (2017). In Action.
- Schwartz, L., Abolhassani, M., Guais, A., Sanders, E., Steyaert, J. M., Campion, F., Israel, M. (2010). A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results. Oncology reports, 23(5), 1407-1416.
- Schwartz, L., Buhler, L., Icard, P., Lincet, H., & Steyaert, J. M. (2014). Metabolic treatment of cancer: intermediate results of a prospective case series. Anticancer research, 34(2), 973-980.
- Schwartz, L., Seyfried, T., Alfarouk, K. O., Moreira, J. D. V., Fais, S. (2017, April). Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH. In Seminars in cancer biology (Vol. 43, pp. 134-138). Academic Press.
- Schwartz, L. (2017). Chlorine dioxide as a possible adjunct to metabolic treatment.
Others articles of the Topic Medicine : Pattie W. Van Hook, Adventist Health Sonora, Electroftalm, P. B. Buckshey, COVID-19 pandemic in the Commonwealth of Independent States, Andrea Ammon, Scheer Memorial Adventist Hospital
Others articles of the Topic France : Lycée Français de Luanda, Marcus Level, Va Bene (L'Algérino song), Jeremias Nussbaum, Philibert du Croc, Christophe Sauniere, Édouard Cointreau
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