Lisa Jones

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Lisa Jones
🏳️ Nationality
🎓 Alma materSyracuse University
Georgia State University
💼 Occupation
Cell footprinting

Lisa M. Jones is an associate professor of pharmaceutical sciences at the University of Maryland, Baltimore (UMB).[1] She developed cell-footprinting, which uses mass spectrometry together with fast photochemical oxidation of proteins (FPOP). Her lab at UMB pursues FPOP uses in the study of proteins for medical and biomedical uses.

Early life and education[edit]

Jones became interested in science as a freshman at high school, where she took part in a national Science Technology Engineering Program.[2] She went to college at Syracuse University.[3] Jones completed her PhD at Georgia State University and specialized in structural biology.[4]

Research and career[edit]

She was a Pfizer postdoctoral researcher at Washington University in St. Louis.[5][2] She joined Indiana University – Purdue University Indianapolis, where she became an associate professor.[6][7] In 2016 Jones won a $1.1 million National Science Foundation Career grant to develop new techniques to study cell membranes.[2] Her award supported research training for students from historically black colleges and universities to work in biochemistry.[2] She developed cell-footprinting, a technique that uses mass spectrometry coupled with in vivo fast photochemical oxidation of proteins (FPOP).[2][8][9] She is recognised for solving new questions in medicine as well as developing important tools for biomedical researchers.[7]

She moved to the University of Maryland School of Pharmacy in 2016.[10] The Jones Lab is a structural proteomics group, who specialist in FPOP using an excimer laser for photolysis, which generates hydroxyl radicals.[11] Hydroxyl radicals go on to oxidise the side chains of amino acids and provide solvent accessibility of proteins within a cell.[12] FPOP can provide information on the sites of ligand binding, protein interaction and protein conformational changes in vivo.[11] Her group has continued to develop the FPOP technique, extending it with a no-flow platform for high-throughput in-cell measurements.[13] In 2019, she received the Biophysical Society's Junior Faculty Award.[14] In protein mass spectrometry reviews, Jones' in vivo FPOP and cross-linking work is frequently referenced and has been described as an exciting and promising avenue for future research.[15][16]

Jones also works on science outreach and improving representation in the sciences. As a mentor in the University of Maryland, Baltimore CURE Scholars Program, she taught middle schoolers how to extract DNA from fruit.[17][18] In 2017, in her capacity as a member of the American Society for Mass Spectrometry Diversity and Outreach Working Group, Jones led a forum and panel about Diversity, Equity, and Inclusion initiatives in the professional association and scientific field.[19] At the University of Maryland, Baltimore, Jones is also co-director of the Initiative to Maximize Student Development (IMSD) Meyerhoff Graduate Fellowship Program, a program for increasing representation in STEM.[20]


  1. "Lisa Jones". Retrieved 19 October 2020. Unknown parameter |url-status= ignored (help)
  2. 2.0 2.1 2.2 2.3 2.4 "IUPUI chemist receives $1.1M NSF grant for research, training of minority future researchers: Newscenter: Indiana University–Purdue University Indianapolis". Retrieved 2018-04-22.
  3. @Victoria08Davis, VICTORIA T. DAVIS. "IUPUI chemist awarded more than $1 million for research, training of minority students". Indianapolis Recorder Newspaper. Retrieved 2018-04-22.
  4. Chea, Emily E.; Jones, Lisa M. (2018-02-12). "Analyzing the structure of macromolecules in their native cellular environment using hydroxyl radical footprinting". Analyst. 143 (4): 798–807. Bibcode:2018Ana...143..798C. doi:10.1039/C7AN01323J. ISSN 1364-5528. PMID 29355258.
  5. Jones, Lisa M.; Zhang, Hao; Vidavsky, Ilan; Gross, Michael L. (2010-02-15). "An On-Line, High-Pressure Digestion System for Protein Characterization by Hydrogen/Deuterium Exchange and Mass Spectrometry". Analytical Chemistry. 82 (4): 1171–1174. doi:10.1021/ac902477u. PMC 2826105. PMID 20095571.
  6. "Lisa Jones". Retrieved 2018-04-22.
  7. 7.0 7.1 Brown, Alex. "IUPUI Professor Receives Lucrative Award". Retrieved 2018-04-22.
  8. "NSF Award Search: Award#1701692 - CAREER: Development of an In Cell Footprinting Method for the Analysis of Protein Structure". Retrieved 2018-04-22.
  9. Rinas, Aimee; Mali, Vishaal S.; Espino, Jessica A.; Jones, Lisa M. (2016-10-07). "Development of a Microflow System for In-Cell Footprinting Coupled with Mass Spectrometry". Analytical Chemistry. 88 (20): 10052–10058. doi:10.1021/acs.analchem.6b02357. PMID 27681498.
  10. "Its official! We're getting FPOP in Baltimore!". 2016-06-11. Retrieved 2018-04-22.
  11. 11.0 11.1 "Lisa Jones". Retrieved 2018-04-22.
  12. "Professor Lisa Jones - Indiana University" (PDF). University of Toledo. 2014-09-24. Retrieved 2018-04-22.
  13. "Proteomic Mass Spec Assesses Biomolecular Teamwork". Genetic Engineering and Biotechnology News. 2020-05-04. Retrieved 2020-06-12.
  14. "PSC Researcher Awarded Biophysical Society's Junior Faculty Award". University of Maryland School of Pharmacy. 2019-03-06. Retrieved 2020-06-12.
  15. Pan, Xiao; Vachet, Richard W. (2020). "Membrane Protein Structures and Interactions from Covalent Labeling Coupled with Mass Spectrometry". Mass Spectrometry Reviews. n/a (n/a). doi:10.1002/mas.21667. ISSN 1098-2787. PMID 33145813 Check |pmid= value (help).
  16. Kaltashov, Igor A.; Bobst, Cedric E.; Pawlowski, Jake; Wang, Guanbo (2020-05-30). "Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics". Journal of Pharmaceutical and Biomedical Analysis. 184: 113169. doi:10.1016/j.jpba.2020.113169. ISSN 0731-7085. PMC 7162711 Check |pmc= value (help). PMID 32092629 Check |pmid= value (help). Unknown parameter |pmc-embargo-date= ignored (help)
  17. Koch, Denise (July 11, 2017). "UMB's CURE Scholars Program Helps Inner City Kids Get Interested In Science". WJZ CBS Baltimore. Unknown parameter |url-status= ignored (help)
  18. Fanning, Patricia (July 14, 2017). "Science Beckons CURE Scholars in Summer". University of Maryland, Baltimore. Retrieved 2021-02-27. Unknown parameter |url-status= ignored (help)
  19. Reid, Gavin E. (September 2017). "American Society for Mass Spectrometry News and Views" (PDF). Unknown parameter |url-status= ignored (help)
  20. "2016-2017 Annual Report". University of Maryland School of Pharmacy. 2017. p. 40. Retrieved 2021-02-27. Lay summary. Unknown parameter |url-status= ignored (help)

External links[edit]

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