MiRNA-205
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Function[edit]
Tumor suppresor: MiR-205 acts either as a tumor suppressor through inhibiting proliferation and invasion, or as an oncogene through facilitating tumor initiation and proliferation, depending on the specific tumor context and target genes.[1]
Genes targeted[edit]
| Target | PMID |
|---|---|
| E2F1 | 21454583 |
| E2F5 | 21454583 |
| HER3 | 24129185 |
| SHIP2 | 19033458 |
| VEGF-A | 22159356 |
| ZEB2 | 25427583, 21426561 |
Disease/Biomarker[edit]
- MiR-205 is frequently downregulated in prostate cancer and acts as a tumor suppressor by inhibiting tumor growth [2].[3]
- For example , hsa-miR-205 is a miRNA that is highly expressed in lung squamous cell carcinomas ( SqCC ) but not in lung adenocarcinomas [4].
- MiR-205 is a tumor suppressor in human breast cancer by post-transcriptional inhibition of HER3 expression.[5]
References[edit]
- ↑ Orang, AV; Safaralizadeh, R; Hosseinpour Feizi, MA (2014). "Insights into the diverse roles of miR-205 in human cancers". Asian Pacific journal of cancer prevention : APJCP. 15 (2): 577–83. PMID 24568460.
- ↑ Wang, N; Li, Q; Feng, NH; Cheng, G; Guan, ZL; Wang, Y; Qin, C; Yin, CJ; Hua, LX (November 2013). "miR-205 is frequently downregulated in prostate cancer and acts as a tumor suppressor by inhibiting tumor growth". Asian journal of andrology. 15 (6): 735–41. PMID 23974361.
- ↑ Kalogirou, C; Spahn, M; Krebs, M; Joniau, S; Lerut, E; Burger, M; Scholz, CJ; Kneitz, S; Riedmiller, H; Kneitz, B (29 October 2013). "MiR-205 is progressively down-regulated in lymph node metastasis but fails as a prognostic biomarker in high-risk prostate cancer". International journal of molecular sciences. 14 (11): 21414–34. PMID 24173237.
- ↑ Bishop, JA; Benjamin, H; Cholakh, H; Chajut, A; Clark, DP; Westra, WH (15 January 2010). "Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach". Clinical cancer research : an official journal of the American Association for Cancer Research. 16 (2): 610–9. PMID 20068099.
- ↑ Wang, Z; Liao, H; Deng, Z; Yang, P; Du, N; Zhanng, Y; Ren, H (8 November 2013). "miRNA-205 affects infiltration and metastasis of breast cancer". Biochemical and biophysical research communications. 441 (1): 139–43. PMID 24129185.
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