Rafael Kramann

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Rafael Johannes Thomas Kramann (born 1981 in Euskirchen) is a German Nephrologist at the Uniklinik Aachen. He is well known for his work on the pathogenesis and experimental treatments of fibrosis.

Early life and career

Kramann studied medicine at the RWTH Aachen and received his doctorate from the Department of Cardiology and Angiology. From 2008 he was an assistant doctor at the Clinic for Nephrology and Clinical Immunology. As postdoctoral researcher he worked with Benjamin Humphreys (and Benjamin Ebert) at Harvard University. Nowadays (2023), Kramann is professor of internal medicine and director of the clinic for kidney and hypertension diseases, rheumatological and immunological diseases (Medical Clinic II) at Uniklinik Aachen.

Kramann conducts translational research in the field of organ fibrosis and was able to clarify the origin and contribution of Myofibroblasts in Fibrosis and identify the protein Nkd2 as a target for potential drug development against fibrosis.

According to Google Scholar, Prof. Kramann has an h-Index of 54, and accoring to Datenbank Scopus 45 (Status July 2023).

Publications (selection)

• Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah A, Nagai J, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, van Roeyen C, Lehkre M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders M, Baan C, Gribnau J, Hoorn EJ, Steffens J, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS and Kramann R. Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease. Nature Genetics 2022 Oct 27 https://doi.org/10.1038/s41588-022-01202-z
• Kuppe C, Ramirez Flores R, Li Z, Hayat S, Levinson RT, Liao X, Hannani MT, Tanevski J, Wünnemann F, Nagai JS, Halder M, Schumacher D, Menzel S, Schäfer G, Hoeft K, Cheng M, Ziegler S, Zhang X, Peisker F, Kaesler N, Saritas T, Xu Y, Kassner A, Gummert J, Morshuis M, Amrute J, Veltrop RJA, Boor P, KLingel K, van Laake L, Vink A, Hoogenboezem RM, Bindels EMJ, van Laake L, Vink Schneider RK, Lavine K, Milting M*, Costa I*, Saez-Rodriguez J* and Kramann R*. Spatial multi-omic map of human myocardial infarction. Nature 2022 608 (7924):766-777 https://doi.org/10.1038/s41586-022-05060-x
• Peisker F, Halder M, Nagai J Ziegler S, Kaesler N, Hoeft K,  Li R, Bindels EMJ, Kuppe C, Moellmann J, Lehrke M, Stoppe C, Schaub MT, Schneider RK, Costa I and Kramann R. Mapping the cardiac vascular niche in heart failure. Nature Communications 2022 May 31;13(1):3027 https://doi.org/10.1038/s41467-022-30682-0
• Jansen J, Reimer KC, Nagai JS, Varghese FS, Overheul GJ, de Beer M, Roverts R, Daviran D, Fermin LAS, Willemsen B, Beukenboom M, Djudjaj S, von Stillfried S, van Eijk L, Mastik M, Bulthuis M, Dunnen WD, van Goor H, Hillebrands JL, Triana SH, Alexandrov T, Timm MC, van den Berge BT, van den Broek M, Nlandu Q, Heijnert J, Bindels EMJ, Hoogenboezem RM, Mooren F, Kuppe C, Miesen P, Grunberg K, Ijzermans T, Steenbergen EJ, Czogalla J, Schreuder MF, Sommerdijk N, Akiva A, Boor P, Puelles V, Floege J, Huber TB, C.M. consortium, van Rij RP, Costa IG*, Schneider RK*, Smeets B*, and Kramann R*, SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids. Cell Stem Cell, 2022. 29(2): p. 217-231 e8. https://doi.org/10.1016/j.stem.2021.12.010
• Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Patón J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamari JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC and Kramann R. Decoding myofibroblast origins in human kidney fibrosis. Nature 2021 589(7841):281-286 https://doi.org/10.1038/s41586-020-2941-1
• Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira MS, Puelles V-G, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R. Gli1+ mesenchymal stromal cells are a key driver of bone marrow fibrosis and an important cellular therapeutic target. Cell Stem Cell 2017 Jun 1;20(6):785-800.e8. https://doi.org/10.1016/j.stem.2017.03.008
• Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell 2016 Nov 3;19(5):628-642 https://doi.org/10.1016/j.stem.2016.08.001
• Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie FP, Henderson JM, Ebert BL, Humphreys BD Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis. Cell Stem Cell 2015 Jan 8;16(1):51-66 https://doi.org/10.1016/j.stem.2014.11.004

Awards (selection)

• 2013 Winner of the Harvard University Innovation Challenge
• 2014 Stanley Shaldon Award of European Renal Association
• 2014 Nils-Alwall-Preis für klinische Forschung der Deutschen Gesellschaft für Nephrologie
• 2015 Bernd-Tersteegen-Preis des Verbands Deutscher Nierenzentren
• 2015 Carl-Ludwig-Preis der Deutschen Gesellschaft für Nephrologie
• 2017 Desiderius Award der Erasmus University Rotterdam
• 2019 Franz-Volhard-Preis der Deutschen Gesellschaft für Nephrologie
• 2021 Theodor-Frerichs-Preis der Deutschen Gesellschaft für Innere Medizin
• 2021 Wilhelm-Vaillant-Preis der Wilhelm-Vaillant-Stiftung

External links

• ukaachen.de/kliniken-institute/klinik-fuer-nieren-und-hochdruckkrankheiten-rheumatolog

References

This article "Rafael Kramann" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Rafael Kramann. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.

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