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John F. Crary, MD-PhD

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John F. Crary, MD-PhD
John Crary.jpg John Crary.jpg
Born1973 (age 50–51)
New York, New York, U.S.
🎓 Alma materBrown University, SUNY Downstate Medical Center, Columbia University Medical Center
💼 Occupation
Known forStudy of tauopathy
🥚 TwitterTwitter=
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John F. Crary, MD-PhD (born 1973) is an American neuropathologist and experimental neurobiologist. He is a full professor with tenure at the Icahn School of Medicine at Mount Sinai where he founded and co-directs the Neuropathology Brain Bank & Research CoRE.[1]

Early life and education[edit]

John F. Crary was born in New York City and raised in Brooklyn. He attended Saint Ann's School, where he developed a creative perspective influenced by his mother, Kinga Crary, an artist and painter.[2] His interest in science and medicine was sparked by his father, Calvert D. Crary, a notable Wall Street analyst specializing in litigation and biotechnology.[3] Crary pursued his undergraduate studies at Brown University, majoring in neuroscience.[4] He was particularly inspired by faculty member Dr. Mark Bear and completed an honors research project on pain processing in the trigeminal system under Dr. David Bereiter.

Career[edit]

After a brief stint at Gradient Technologies, Crary began his MD-PhD at SUNY Downstate in 1997, focusing his thesis on PKMzeta in Alzheimer's disease under the mentorship of two leading neuroscientists: Dr. Todd Sacktor, MD, known for his discovery of PKMzeta,[5] and Suzanne Mirra, MD who devised the CERAD criteria for the neuropathological diagnosis of Alzheimer's disease.[6] He completed his anatomical and neuropathology residency and fellowship at Columbia University, where he was mentored by Michael Shelanski, MD-PhD. There, he developed significant research on "tangle-only" dementia which led to the characterization of primary age-related tauopathy (PART).

In 2014, Crary moved to the Icahn School of Medicine at Mount Sinai, establishing a new laboratory and brain bank focused on movement disorders and chronic traumatic encephalopathy. His work has continued to influence the field significantly, and is a frequent invited lecturer at New York Academy of the Sciences[7].[according to whom?]

Research and contributions to diagnostic neuropathology[edit]

Dr. Crary's research program focuses on the molecular and genetic mechanisms underlying age-related tauopathy, employing histopathological, computational, biochemical, genetic, and molecular approaches. He has led efforts to define post-mortem diagnostic criteria for various tauopathies. This includes primary age-related tauopathy,[8] aging-related tau astrogliopathy,[9] chronic traumatic encephalopathy,[10][11] and progressive supranuclear palsy.[12] He also contributed substantially to understanding the neurological consequences of neuroinfectious diseases such as HIV[13] and SARS-CoV-2.[14]

Early neurofibrillary tangles in the entorhinal cortex of a subject with primary age-related tauopathy (PART), which was described by Crary et al., in 2014[15]

Digital neuropathology and machine learning[edit]

Crary is a leader in applying advanced artificial intelligence / machine learning techniques to the histomorphological assessment of neurodegeneration. He has pioneered the use of convolutional neural networks for analyzing whole slide images from dementia patients, significantly advancing digital neuropathology. Dr. Crary's team was the first to apply convolutional neural networks to assessing tau pathology.[16][17] The Crary lab showed that deep learning algorithms can predict cognitive function[18] and further, using multiple instance learning, Dr. Crary's team developed an approach to measuring brain aging, termed HistoAge.[19]

Awards and recognition[edit]

Crary has received several prestigious awards, including the Chancellor's Award for Student Excellence, the SUNY Downstate Medical Center Award for Excellence in Pathology, and the Medical Student Prize for Excellence in Neurology by the American Academy of Neurology. He was also a Louis V. Gerstner, Jr. Scholar in 2011 and received the Karen Strauss Cook Research Scholar Award and the Alexander Saint Amand Scholar Award from the Icahn School of Medicine. He is an editor of Acta Neuropathologica and Free Neuropathology. He is also a member of the Tau Consortium.

References[edit]

  1. "How Innovative Technology Is Expanding Our Scientists' Access to Human Brain Tissue". The Friedman Brain Institute Spring 2024 Newsletter. Icahn School of Medicine at Mount Sinai. Retrieved 11 May 2024.
  2. [www.kingacrary.com "Kinga Crary Fine Art"] Check |url= value (help). Kinga Crary Fine Art. Retrieved 11 May 2024.
  3. Arnold, Laurence. "Calvert Crary, Wall Street Eye on Corporate Lawsuits, Dies at 69". Bloomberg News. Bloomberg. Retrieved 11 May 2024.
  4. Liber Brunensis. Brown University. May, 1996. Retrieved 11 May 2024. Check date values in: |date= (help) Search this book on
  5. Pastalkova, E; Serrano, P; Pinkhasova, D; Wallace, E; Fenton, AA; Sacktor, TC (25 August 2006). "Storage of spatial information by the maintenance mechanism of LTP". Science (New York, N.Y.). 313 (5790): 1141–4. doi:10.1126/science.1128657. PMID 16931766.
  6. Mirra, SS; Heyman, A; McKeel, D; Sumi, SM; Crain, BJ; Brownlee, LM; Vogel, FS; Hughes, JP; van Belle, G; Berg, L (April 1991). "The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease". Neurology. 41 (4): 479–86. doi:10.1212/wnl.41.4.479. PMID 2011243.
  7. "The Academy Blog". The New Wave of AI in Healthcare. New York Academy of Sciences. Retrieved 11 May 2024.
  8. Crary, JF; Trojanowski, JQ; Schneider, JA; Abisambra, JF; Abner, EL; Alafuzoff, I; Arnold, SE; Attems, J; Beach, TG; Bigio, EH; Cairns, NJ; Dickson, DW; Gearing, M; Grinberg, LT; Hof, PR; Hyman, BT; Jellinger, K; Jicha, GA; Kovacs, GG; Knopman, DS; Kofler, J; Kukull, WA; Mackenzie, IR; Masliah, E; McKee, A; Montine, TJ; Murray, ME; Neltner, JH; Santa-Maria, I; Seeley, WW; Serrano-Pozo, A; Shelanski, ML; Stein, T; Takao, M; Thal, DR; Toledo, JB; Troncoso, JC; Vonsattel, JP; White CL, 3rd; Wisniewski, T; Woltjer, RL; Yamada, M; Nelson, PT (December 2014). "Primary age-related tauopathy (PART): a common pathology associated with human aging". Acta neuropathologica. 128 (6): 755–66. doi:10.1007/s00401-014-1349-0. PMID 25348064.
  9. Kovacs, GG; Ferrer, I; Grinberg, LT; Alafuzoff, I; Attems, J; Budka, H; Cairns, NJ; Crary, JF; Duyckaerts, C; Ghetti, B; Halliday, GM; Ironside, JW; Love, S; Mackenzie, IR; Munoz, DG; Murray, ME; Nelson, PT; Takahashi, H; Trojanowski, JQ; Ansorge, O; Arzberger, T; Baborie, A; Beach, TG; Bieniek, KF; Bigio, EH; Bodi, I; Dugger, BN; Feany, M; Gelpi, E; Gentleman, SM; Giaccone, G; Hatanpaa, KJ; Heale, R; Hof, PR; Hofer, M; Hortobágyi, T; Jellinger, K; Jicha, GA; Ince, P; Kofler, J; Kövari, E; Kril, JJ; Mann, DM; Matej, R; McKee, AC; McLean, C; Milenkovic, I; Montine, TJ; Murayama, S; Lee, EB; Rahimi, J; Rodriguez, RD; Rozemüller, A; Schneider, JA; Schultz, C; Seeley, W; Seilhean, D; Smith, C; Tagliavini, F; Takao, M; Thal, DR; Toledo, JB; Tolnay, M; Troncoso, JC; Vinters, HV; Weis, S; Wharton, SB; White CL, 3rd; Wisniewski, T; Woulfe, JM; Yamada, M; Dickson, DW (January 2016). "Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy". Acta neuropathologica. 131 (1): 87–102. doi:10.1007/s00401-015-1509-x. PMID 26659578.
  10. McKee, AC; Cairns, NJ; Dickson, DW; Folkerth, RD; Keene, CD; Litvan, I; Perl, DP; Stein, TD; Vonsattel, JP; Stewart, W; Tripodis, Y; Crary, JF; Bieniek, KF; Dams-O'Connor, K; Alvarez, VE; Gordon, WA; TBI/CTE, group (January 2016). "The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy". Acta neuropathologica. 131 (1): 75–86. doi:10.1007/s00401-015-1515-z. PMID 26667418.
  11. Bieniek, KF; Cairns, NJ; Crary, JF; Dickson, DW; Folkerth, RD; Keene, CD; Litvan, I; Perl, DP; Stein, TD; Vonsattel, JP; Stewart, W; Dams-O'Connor, K; Gordon, WA; Tripodis, Y; Alvarez, VE; Mez, J; Alosco, ML; McKee, AC; TBI/CTE Research, Group (22 February 2021). "The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy". Journal of neuropathology and experimental neurology. 80 (3): 210–219. doi:10.1093/jnen/nlab001. PMID 33611507 Check |pmid= value (help).
  12. Roemer, SF; Grinberg, LT; Crary, JF; Seeley, WW; McKee, AC; Kovacs, GG; Beach, TG; Duyckaerts, C; Ferrer, IA; Gelpi, E; Lee, EB; Revesz, T; White CL, 3rd; Yoshida, M; Pereira, FL; Whitney, K; Ghayal, NB; Dickson, DW (October 2022). "Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy". Acta neuropathologica. 144 (4): 603–614. doi:10.1007/s00401-022-02479-4. PMID 35947184 Check |pmid= value (help).
  13. Morgello, S; Cortes, EP; Gensler, G; Meloni, G; Jacobs, MM; Murray, J; Borukov, V; Crary, JF (15 July 2021). "HIV disease duration, but not active brain infection, predicts cortical amyloid beta deposition". AIDS (London, England). 35 (9): 1403–1412. doi:10.1097/QAD.0000000000002893. PMID 33813555 Check |pmid= value (help).
  14. Troxel, AB; Bind, MC; Flotte, TJ; Cordon-Cardo, C; Decker, LA; Finn, AV; Padera, RF; Reichard, RR; Stone, JR; Adolphi, NL; Casimero, FVC; Crary, JF; Elifritz, J; Faustin, A; Ghosh, SKB; Krausert, A; Martinez-Lage, M; Melamed, J; Mitchell RA, Jr; Sampson, BA; Seifert, AC; Simsir, A; Adams, C; Haasnoot, S; Hafner, S; Siciliano, MA; Vallejos, BB; Del Boccio, P; Lamendola-Essel, MF; Young, CE; Kewlani, D; Akinbo, PA; Parent, B; Chung, A; Cato, TC; Mudumbi, PC; Esquenazi-Karonika, S; Wood, MJ; Chan, J; Monteiro, J; Shinnick, DJ; Thaweethai, T; Nguyen, AN; Fitzgerald, ML; Perlowski, AA; Stiles, LE; Paskett, ML; Katz, SD; Foulkes, AS; RECOVER Initiative Autopsy, Group (2024). "Researching COVID to enhance recovery (RECOVER) tissue pathology study protocol: Rationale, objectives, and design". PloS one. 19 (1): e0285645. doi:10.1371/journal.pone.0285645. PMID 38198481 Check |pmid= value (help).
  15. Crary, John F.; Trojanowski, John Q.; Schneider, Julie A.; Abisambra, Jose F.; Abner, Erin L.; Alafuzoff, Irina; Arnold, Steven E.; Attems, Johannes; Beach, Thomas G.; Bigio, Eileen H.; Cairns, Nigel J.; Dickson, Dennis W.; Gearing, Marla; Grinberg, Lea T.; Hof, Patrick R.; Hyman, Bradley T.; Jellinger, Kurt; Jicha, Gregory A.; Kovacs, Gabor G.; Knopman, David S.; Kofler, Julia; Kukull, Walter A.; Mackenzie, Ian R.; Masliah, Eliezer; McKee, Ann; Montine, Thomas J.; Murray, Melissa E.; Neltner, Janna H.; Santa-Maria, Ismael; Seeley, William W.; Serrano-Pozo, Alberto; Shelanski, Michael L.; Stein, Thor; Takao, Masaki; Thal, Dietmar R.; Toledo, Jonathan B.; Troncoso, Juan C.; Vonsattel, Jean Paul; White, Charles L.; Wisniewski, Thomas; Woltjer, Randall L.; Yamada, Masahito; Nelson, Peter T. (December 2014). "Primary age-related tauopathy (PART): a common pathology associated with human aging". Acta Neuropathologica. 128 (6): 755–766. doi:10.1007/s00401-014-1349-0.
  16. Signaevsky, M; Prastawa, M; Farrell, K; Tabish, N; Baldwin, E; Han, N; Iida, MA; Koll, J; Bryce, C; Purohit, D; Haroutunian, V; McKee, AC; Stein, TD; White CL, 3rd; Walker, J; Richardson, TE; Hanson, R; Donovan, MJ; Cordon-Cardo, C; Zeineh, J; Fernandez, G; Crary, JF (July 2019). "Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy". Laboratory investigation; a journal of technical methods and pathology. 99 (7): 1019–1029. doi:10.1038/s41374-019-0202-4. PMID 30770886.
  17. Marx, GA; Koenigsberg, DG; McKenzie, AT; Kauffman, J; Hanson, RW; Whitney, K; Signaevsky, M; Prastawa, M; Iida, MA; White CL, 3rd; Walker, JM; Richardson, TE; Koll, J; Fernandez, G; Zeineh, J; Cordon-Cardo, C; Crary, JF; Farrell, K; PART working, group (31 October 2022). "Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment". Acta neuropathologica communications. 10 (1): 157. doi:10.1186/s40478-022-01457-x. PMID 36316708 Check |pmid= value (help).
  18. McKenzie, AT; Marx, GA; Koenigsberg, D; Sawyer, M; Iida, MA; Walker, JM; Richardson, TE; Campanella, G; Attems, J; McKee, AC; Stein, TD; Fuchs, TJ; White CL, 3rd; PART working, group; Farrell, K; Crary, JF (21 September 2022). "Interpretable deep learning of myelin histopathology in age-related cognitive impairment". Acta neuropathologica communications. 10 (1): 131. doi:10.1186/s40478-022-01425-5. PMID 36127723 Check |pmid= value (help).
  19. Marx, GA; Kauffman, J; McKenzie, AT; Koenigsberg, DG; McMillan, CT; Morgello, S; Karlovich, E; Insausti, R; Richardson, TE; Walker, JM; White CL, 3rd; Babrowicz, BM; Shen, L; McKee, AC; Stein, TD; PART Working, Group; Farrell, K; Crary, JF (December 2023). "Histopathologic brain age estimation via multiple instance learning". Acta neuropathologica. 146 (6): 785–802. doi:10.1007/s00401-023-02636-3. PMID 37815677 Check |pmid= value (help).


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