Alessio Lanna
Alessio Lanna is an Italian-born, UK-trained biologist who has been researching anti-aging and rejuvenating molecular processes since 2011 at University College London (UCL) and Oxford University.[1] He is the founder and CEO of Sentcell, a New Chemical Entity (NCE) company developing first-in-class therapies for human rejuvenation. Lanna's research focuses on T-cells and their roles in maintaining functionality over time.[2] He is developing a dual-based approach to reverse the aging process, either by rejuvenating the aging clock at later points in life or delaying its onset by acting at an earlier point.[3] Lanna's research has been published in academic journals including Nature Immunology and Nature Cell Biology.[4][5]
Early life and education
Lanna started his academic career in Rome, Italy, where he undertook summa cum laude Bachelor of Science (Bsc) and Master of Research (M. Res) in pharmaceutical biotechnologies at Tor Vergata and Sapienza Universities of Rome.[6] Lanna later completed a Ph.D. at UCL through a Medical Research Council Ph.D. studentship from 2011 to 2016[5]. He then continued his research as a Sir Henry Wellcome Trust Post-Doctoral Fellow at the University of Oxford from 2016 to 2019, credited as one of the most prestigious Post-Doctoral Fellowship in the United Kingdom.[1]
Lanna currently holds an Honorary Professorship at UCL in recognition of his groundbreaking research in the field of cellular aging and T lymphocyte senescence. He was the first to identify the multi-druggable pro-aging sMAC complex and the anti-aging mechanism of telomere vesicle transfer at the immune synapse between APCs and T lymphocytes.[7][8][9]
Research focus and impact
In 2019, Lanna founded Sentcell to develop innovative compounds that could rejuvenate the immune system. His current work is focused on the sMAC (Senescent Macromolecular Complex), a large macromolecular complex that forms during the aging of T cells and other cell types. The formation of sMAC has been linked to the decline of the immune system, and increased risk of infections, cancers, and death.[10][11][12][13][14] Lanna is credited with leading Sentcell's efforts to develop innovative and cutting-edge compounds and strategies for human rejuvenation treatments through cell rejuvenation.[15] Under his leadership, the company has made significant progress in its research and development efforts and has established itself as a promising IMPD/IND stage biotech startup.[16] His latest discoveries on telomere transfer illuminated a different rejuvenation process that acts prior to telomerase in cells introducing the possibilities of novel forms of prophylactic therapies of age. This suggests that telomere transplants may have therapeutic implications for aging and its associated diseases, which could be independent of telomerase reactivation.[17][18]
Selected publications
- An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory. Lanna, A., Vaz, B., D’Ambra, C. et al. (2022) DOI 10.1038/s41556-022-00991-z
- The regulation of T cell senescence and metabolism by P38 mapkinase signaling. Lanna, A., Akbar, A.N. (2017) DOI 10.1093/geroni/igx004.4558
- A sestrin-dependent Erk–Jnk–p38 MAPK activation complex inhibits immunity during aging. Lanna, A., Gomes, D. C. O., Muller-Durovic, B. et al. (2017) DOI 10.1038/ni.3665
- Measuring Telomerase Activity in Senescent Human T Cells Upon Genetic Modification. Lanna, A. (2017) DOI 10.1007/978-1-4939-6548-9_10
- Senescence of T lymphocytes: implications for enhancing human immunity. Akbar, A.N., Henson, S.M., Lanna A. (2016) DOI 10.1016/j.it.2016.09.002
- The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Lanna A., Henson S. M., Escors D., Akbar A. N. (2014) DOI 10.1038/ni.2981.
References
- ↑ 1.0 1.1 "Metabolic control of T-cell receptor signalling". Wellcome.
- ↑ Hanks, Micah (November 8, 2022). ""Unexpected" Discovery in Anti-Aging Science Reveals Process that Lengthens Immune Cell Lifespan". The Debrief.
- ↑ "New mechanism may prevent the natural aging of immune cells". News-Medical.net. September 15, 2022.
- ↑ Bawden, Tom (December 28, 2022). "A cure for old-age? Scientists to trial new drug which could increase life expectancy to 120". inews.co.uk.
- ↑ 5.0 5.1 "New mechanism extends life of immune system". UCL News. September 23, 2022.
- ↑ "FEDERICA RINALDI | MOLECULAR MEDICINE". phd.uniroma1.it.
- ↑ Foley, John F. (2022). "Telomeres to go". Science Signaling. 15 (752): eade9136. doi:10.1126/scisignal.ade9136. PMID 36126117 Check
|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ Bird, Lucy (November 28, 2022). "Gift of life: APC to T cell telomere transfer". Nature Reviews Immunology. 22 (11): 653. doi:10.1038/s41577-022-00790-5. PMID 36175503 Check
|pmid=value (help) – via www.nature.com. Unknown parameter|s2cid=ignored (help) - ↑ "UCL Researchers Reveal Molecules Responsible for Aging in Immunity Cells | UCL Infection and Immunity". blogs.ucl.ac.uk.
- ↑ Allard-Chamard, Hugues; Pillai, Shiv (July 21, 2017). "Turning Charon around on the Styx?". Science Immunology. 2 (13): eaao2062. doi:10.1126/sciimmunol.aao2062. PMID 28783707. Unknown parameter
|s2cid=ignored (help) - ↑ "Antigen Presenting Cells Donate Telomeres to T Cells to Increase their Longevity". Fight Aging!. September 22, 2022.
- ↑ Lanna, Alessio; Gomes, Daniel C. O.; Muller-Durovic, Bojana; McDonnell, Thomas; Escors, David; Gilroy, Derek W.; Lee, Jun Hee; Karin, Michael; Akbar, Arne N. (March 28, 2017). "A sestrin-dependent Erk–Jnk–p38 MAPK activation complex inhibits immunity during aging". Nature Immunology. 18 (3): 354–363. doi:10.1038/ni.3665. PMC 5321575. PMID 28114291.
- ↑ Lanna, Alessio; Vaz, Bruno; D’Ambra, Clara; Valvo, Salvatore; Vuotto, Claudia; Chiurchiù, Valerio; Devine, Oliver; Sanchez, Massimo; Borsellino, Giovanna; Akbar, Arne N.; De Bardi, Marco; Gilroy, Derek W.; Dustin, Michael L.; Blumer, Brendan; Karin, Michael (October 28, 2022). "An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory". Nature Cell Biology. 24 (10): 1461–1474. doi:10.1038/s41556-022-00991-z. PMC 7613731 Check
|pmc=value (help). PMID 36109671 Check|pmid=value (help). - ↑ Lanna, Alessio; Henson, Sian M.; Escors, David; Akbar, Arne N. (October 28, 2014). "The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells". Nature Immunology. 15 (10): 965–972. doi:10.1038/ni.2981. PMC 4190666. PMID 25151490.
- ↑ "Are you as old as what you eat? Researchers learn how to rejuvenate aging immune cells". medicalxpress.com.
- ↑ London, University College (November 4, 2022). ""Unexpected" – Scientists Discover an Anti-Aging Mechanism". SciTechDaily.
- ↑ "T Cells Ward Off Aging with Help from Their Friends". The Scientist Magazine®.
- ↑ "Scientists Uncover Mechanism to Slow Down Immune Cell Ageing". Medscape UK.
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