Alexander Bolotin
Alexander Bolotin worked at the French National Institute for Agricultural Research after emigrating from Russia.[1] He built on the research of Alex van Belkum who had discovered prokaryotic sequences that would later become known as CRISPR.[2] Bolotin's research into CRISPR also benefited from the discovery by Ruud Jansen in 2002 that CRISPR DNA sequences have associated cas proteins. [3] In September 2005, Bolotin published a paper in Microbiology showing that CRISPR sequences have considerable genetic homology with many known bacteriophage sequences.[4] This same hypothesis had been proposed earlier in 2005 by Francisco Mojica[5] and Christine Pourcel[6]. However, Bolotin was the first to propose a mechanism where the cas proteins created new CRISPR sequences.
References[edit]
- ↑ https://www.sciencedirect.com/science/article/pii/S0092867415017055
- ↑ https://mmbr.asm.org/content/62/2/275.short
- ↑ https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2958.2002.02839.x
- ↑ https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.28048-0
- ↑ https://link.springer.com/article/10.1007/s00239-004-0046-3
- ↑ https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.27437-0
Alexander Bolotin[edit]
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