Alicia L. Bruzos
| Alicia L. Bruzos | |
|---|---|
| Born | 29 March 1993 Lugo, Spain |
| 🏳️ Nationality | Spanish |
| 🎓 Alma mater | Universidade de Santiago de Compostela |
| 💼 Occupation | |
Alicia López Bruzos (born 29 March 1993) is a Spanish biologist and bioinformatician. She works at the Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) and teaches genetics in the biology degree from the Universidade de Santiago de Compostela (Spain).
Personal life and educational background
Alicia L. Bruzos was born in Lugo (Galicia, Spain) in 1993, although she spent her childhood in Viveiro where she attended Colegio Lois Tobio and IES Vilar Ponte. She is the daughter of a primary school teacher and a mine foreman.
During her childhood, she attended the Professional Conservatory of Music, obtaining the elementary degree with two specialisations: traverse flute and piano. She also participated in art and literature competitions, winning several awards during these years. At the age of 14, she participated in her first international exchange to learn French in Lannion (France), which continued a few years later with a summer scholarship from the Xunta de Galicia to learn French in Camblanes (France). At the age of 16, she was diagnosed with radial nerve paralysis and, during the following years, she underwent surgery three times.
She started university in 2011, and two years later, Alicia got an Erasmus scholarship to study one year abroad at Université Libre de Bruxelles (Belgium), where she fell in love with evolutionary biology. She spent the summer working in the laboratory of Prof. Patrick Mardulyn.[1] and learning some basic molecular biology techniques. In 2015, she obtained a BSc. in biology from Universidade de Santiago de Compostela (Spain) after presenting her degree thesis with honours about photosynthesis variability under heat stress supervised by Rubén Retuerto (Ecology department).
Afterwards, she moved to Barcelona to do a specialisation in bioinformatics from Universitat Autònoma de Barcelona (Spain), which would lead to publishing her first article with some analyses of her master thesis that were comprised in a major publication of Nature [2] [3].
Scientific career
Alicia is a scientist researching the genetic causes of contagious metastases under the sea. In 2016, she started working in the laboratory of PhD. Jose Tubio, doing an internship and then enrolling in a PhD programme of Universidade de Vigo (Spain) funded by a PhD fellowship from the Spanish Ministry of Economy, Industry and Competivity (Ref. BES-2016-078166)[4]. Due to the transfer of the ERC Scuba Cancers project[5][6], she moved back to Universidade de Santiago de Compostela (Spain) and enrolled in the Molecular Medicine PhD program.
Alicia made four research stays in other laboratories during her PhD. In 2018, she went to the laboratory of PhD. Michael Metzger of the Pacific Northwest Research Institute (Seattle, USA) to learn gene-editing techniques financed by the Spanish Ministry of Science. The following year, she moved to National University Ireland Galway (Ireland) to study the disseminated neoplasia of Irish cockles financed by Assemble Plus (grant agreement no. 730984). In 2020, she worked with the laboratory of Prof. David Posada where she learned phylogenomic and statistical techniques that she applied to her pre-doctoral research. Finally, in 2021 she moved to the laboratory of PhD. Young Seok Ju at the Korean Advanced Institute of Science and Technology (Daejeon, South Korea) financed by a travel grant of the Boehringer Ingelheim Fonds to learn about transcriptomics and cell-of-origin analysis.
Moreover, she is committed to bringing science from the laboratory to the streets, therefore, she actively participates in several scientific outreach activities:
- ASEICA video competition explaining her PhD thesis with more than 11,000 views.
- Workshops such as Conócelas, Ciencia Singular or DNA day in the school.
- Written articles for the general public in blogs[7] or popular magazines[8].
- Conferences for the general public[9][10]
Selected publications
- The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (includes Bruzos AL). 2020. "Pan-Cancer analysis of whole genomes". Nature, 578:82-93. | IF = 43.070; NumCites = 6. | The flagship of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium that describes the main scientific findings from the analyses of ~3,000 cancer whole genomes and their matched normal tissues across 38 tumour types. Alicia did bioinformatic analysis during her Master Thesis that ended up being one of the figures of this paper.[2]
- Rodriguez-Martin et al (includes Bruzos AL). 2020. "Pan-Cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition". Nature Genetics, 52:306-319. | IF = 25.455; NumCites = 0. | Identification of a new mutational mechanism in cancer by with aberrant integration of L1 elements promote chromosomal rearrangements such as megabase-size genomic deletions that on occasion remove tumour suppressor genes, contributing to cancer progression. Alicia catalogued the retrotransposition events of LINE-1.[11]
- Bruzos AL et al. 2019. “WGS y cromosomas de berberechos con cáncer transmisible: efectos en la integridad del ADN”. Book chapter in: Rey-Méndez M., et al. Foro dos Recursos Mariños e da Acuicultura das Rías Galegas. 22: 265-273. ISBN 978-84-09-19360-8; legal deposit: C 2014-2016 | Comparison and results of several DNA isolation protocols in cockle cancer samples to meet the requirements of whole genome sequencing (WGS).
- Bruzos AL et al. 2017. "Genoma de referencia de berberecho: estimación de su tamaño". Jóvenes investigadores, 47-51. ISBN 978-84-945079-9-1; legal deposit: S.469-2017. | Size estimation of the cockle reference genome to study cockle transmissible cancers.
- Bruzos AL et al. 2017. “Primeros pasos para decodificar el genoma de berberecho, Cerastoderma edule (Linnaeus, 1758)”. Book chapter in: Rey-Méndez M., et al. Foro dos Recursos Mariños e da Acuicultura das Rías Galegas. 20: 227-237. ISBN 978-84-09-01474-3; legal deposit: C 2014-2016 | Preliminary results of the cockle reference genome required to study cockle transmissible cancers.
Awards and fellowships
- 2021: Travel grant. Boehringer Ingelheim Fonds, South Korea.
- 2019: Best Scientific Panel Prize. XXII Foro dos Recursos Mariños e da Acuicultura das Rías Galegas, Spain. Second place[12].
- 2017: EuroMarine Young Scientist Fellowship Programme. Universidade de Vigo & European Marine Research Network, Spain.
- 2017: Best Scientific Panel Prize. XX Foro dos Recursos Mariños e da Acuicultura das Rías Galegas, Spain. First place[13]
- 2017: PhD fellowship. Spanish Ministry of Economy, Industry and Competitivity (Ref. BES-2016-078166), Spain.[4]
- 2015: National Speech Competition: “Transmito, luego existo”. Finalist.
- 2013: Erasmus Scholarship. Université Libre de Bruxelles, Belgium. One year to study abroad.
- 2013: Open Software Translation Award. Escola Técnica Superior de Enxeñaría (ETSE), Spain. First place.
- 2009: Summer Exchange Scholarship. Xunta de Galicia. France.
- 2007: Ourol Literary Competition. Concello de Ourol, Spain. Second place.
- 2006: Drawing Christmas. Xermolos Association, Spain. Second place.
- 2004: Terra Chá Competition. Concello de Ourol, Spain. Poetry Prize.
References
- ↑ Mardulyn, Patrick. "Phylogeography, dispersion, and speciation of herbivorous insects". Archived from the original on 2021-04-18. Unknown parameter
|url-status=ignored (help) - ↑ 2.0 2.1 The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (February 2020). "Pan-cancer analysis of whole genomes". Nature. 578 (7793): 82–93. Bibcode:2020Natur.578...82I. doi:10.1038/s41586-020-1969-6. ISSN 0028-0836. PMC 7025898 Check
|pmc=value (help). PMID 32025007 Check|pmid=value (help). Archived from the original on 2021-02-04. Retrieved 2021-02-01. Unknown parameter|url-status=ignored (help) - ↑ Bruzos, A.L. "How my Master's thesis on jumping-genes became part of an article in Nature". EACR magazine. Archived from the original on 2021-02-05. Unknown parameter
|url-status=ignored (help) - ↑ 4.0 4.1 "Resolución de la Presidencia de la Agencia Estatal de Investigación, por la que se conceden ayudas para contratos predoctorales para la formación de doctores, convocatoria 2015" (PDF). Ministerio de Economía, Industria y Competitividad. Archived from the original (PDF) on 2022-03-10. Retrieved 2021-02-01. Unknown parameter
|url-status=ignored (help) - ↑ "ERC starting grant project website: SCUBA CANCERS". Archived from the original on 2021-01-20. Unknown parameter
|url-status=ignored (help) - ↑ European Commission. "SCUBA CANCERS. Finding the genetic causes of contagious metastases under the sea. Grant agreement ID: 716290". Archived from the original on 2022-03-10. Unknown parameter
|url-status=ignored (help) - ↑ Blog Océano Ecimat (May 11, 2018). "Cáncer transmisible de bivalvos para desentrañar la evolución del cáncer". Archived from the original on March 10, 2022. Unknown parameter
|url-status=ignored (help) - ↑ Bruzos, AL. "Las claves de la metástasis enterradas en la arena". Encuentros en la Biología. 169: 5–7. ISSN 2254-0296. Archived from the original on 2021-01-19. Retrieved 2021-02-01. Unknown parameter
|url-status=ignored (help) - ↑ Bruzos, AL. "Conference "Café con Sal". Unraveling cancer evolution using cockles. (Vigo)". Archived from the original on 2021-02-06. Unknown parameter
|url-status=ignored (help) - ↑ Bruzos, AL. "Conference "Happy Fridays": Understanding metastasis through transmissible cancers (Santiago de Compostela)". Archived from the original on 2021-02-08. Unknown parameter
|url-status=ignored (help) - ↑ PCAWG Structural Variation Working Group; PCAWG Consortium; Rodriguez-Martin, Bernardo; Alvarez, Eva G.; Baez-Ortega, Adrian; Zamora, Jorge; Supek, Fran; Demeulemeester, Jonas; Santamarina, Martin; Ju, Young Seok; Temes, Javier (March 2020). "Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition". Nature Genetics. 52 (3): 306–319. doi:10.1038/s41588-019-0562-0. ISSN 1061-4036. PMC 7058536 Check
|pmc=value (help). PMID 32024998 Check|pmid=value (help). Archived from the original on 2020-11-18. Retrieved 2021-02-01. Unknown parameter|url-status=ignored (help) - ↑ "Second prize for the poster about whole-genome sequencing and chromosomes of cockles". Genomes and Disease Lab News. October 11, 2019. Archived from the original on 7 February 2021. Unknown parameter
|url-status=ignored (help) - ↑ "Best poster presentation at the XX Marine Resources Forum for a Scuba Cancers poster". Genomes and Disease Lab News. October 11, 2017. Archived from the original on 8 February 2021. Unknown parameter
|url-status=ignored (help)
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