Alpravalzafone
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| Identifiers | |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}} |
| Chemical and physical data | |
| Formula | C22H25Cl2N5O2 |
| Molar mass | 462.38 g·mol−1 |
| 3D model (JSmol) | |
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Alpravalzafone is a water-soluble prodrug of what is currently to be assumed Alprazolam.[1] It recently surfaced as a designer drug in Germany which is adjacent in its design to the Japanese benzodiazepine prodrug Rilmazafone.[2] Little is known about the exact metabolites of this prodrug so far, but preliminary reports by users have demonstrated the presence of metabolites found in users of other common benzodiazepines. The report included detectable levels of Oxazepam, Hydroxy-Alprazolam (an Alprazolam metabolite) and Alprazolam. It is therefore assumed that the drug undergoes metabolism to Alprazolam in the blood in a similar fashion as Rilmazafone would, closing the open ring to form the diazepine structure.
Chemistry
According to user reports, Alpravalzafone is very soluble in a 37,5% solution of alcohol in water.
Legal status
Alpravalzafone is as of early May 2026 not a controlled substance in Germany, however, would fall under the restrictions imposed by the NpSG as soon as it enters non-acidic conditions and hydrolizes back into the closed ring form.
Alpravalzafone is not currently considered a controlled substance in Russia or Belarus.[3]
See also
- Rilmazafone
- Rilmazolam
- Avizafone
- Alprazolam triazolobenzophenone
- Clonazafone desglycyl
- Diclazafone desglycyl
- Noravizafone desglycyl
- GL-II-73
References
- ↑ Yurchenko, Ruslan; Vydra, Tanya; Galetskaya, Inna; Piatsetskaya, Anastasiya (31 March 2026). "Мониторинг рынка психоактивной продукции. Анализ тенденций. Выпуск 75. Март 2026. (язык - русский)". АИПСИН (75): 5. doi:10.13140/RG.2.2.20692.36486.
- ↑ "Alpravalzafone - CyberChemicals". CyberChemicals. Cyber-Chemicals UG (haftungsbeschränkt). Retrieved 10 May 2026.
- ↑ "Альправальзафон (Alpravalzafone)". Аипсин. Retrieved 10 May 2026.
Category:Designer drugs Category:GABAA receptor positive allosteric modulators Category:Triazolobenzodiazepines
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