Annie Kathuria
| Annie Kathuria | |
|---|---|
| File:Annie Kathuria.jpgAnnie Kathuria.jpg | |
| Born | |
| 🎓 Alma mater | Harvard Medical School Massachusetts General Hospital |
| 💼 Occupation | Research Faculty, Instructor in Psychiatry |
Annie Kathuria is an American neuroscientist who works at Harvard Medical School, psychiatry department, as an Instructor of Investigation.[1] She is affiliated with Chemical Biology and Therapeutics Science at the Broad Institute, Massachusetts General Hospital and Harvard Stem Cell Institute.[1] She usually does her research in Tissue engineering, Neuroscience, Genetics and Development biology.[2]
Education
Kathuria did a double major in Neuroscience and Genetics, Cell Biology and Development at the University of Minnesota.[citation needed] Then she completed a Master of Science and a PhD from King's College London.[3][4] During her time in her PhD she trained under Jack Price, Fiona Watt, and Simon Baron-Cohen.[citation needed]
Selected publications
- “Stem Cell “MINI-BRAINS” for studying the Biology of Bipolar Disorder” published on September 9, 2020, on Genome Medicine. Kathuria was a postdoctoral research fellow in Center for Genomic Medicine, Massachusetts General Hospital. In her study, she initiated pluripotent stem cells (iPSCs) were produced from skin cells from patients with bipolar disorder (BPD) and solid control subjects, which were at that point utilized to form cerebral organoids, three-dimensional neuronal culture frameworks that summarize the advancement of the human forebrain.[5]
- “Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia” by Annie Kathuria.[2][6]
- Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development, published in 2018.[7] Through this study, Dr. Kathuria established a robust method of generating stem cells from hair cells and found a viable therapeutic target for treating autism caused neurological deficits using gene therapy.
- “Distinct effects of interleukin-6 and interferon-? on differentiating human cortical neurons” published in April 2022.[2] “Synaptic Deficit in iPSC-derived cortical Interneurons in Schizophrenia is mediated by NLGN2 and rescued by N-acetylcyteine” by Annie Kathuria, published on March 18,2020.[2][8][9] In this publication, she has found a potential drug for the treatment for the oxidative stress frequently reported in schizophrenia. Such work serves as the basis for larger clinical trials and represents a viable therapeutic agent against this devastating disorder.
Awards and honors
On January 17, 2020 Kathuria received NARSAD Young Investigator Award from Brain and Behavior Research Foundation.[10]
References
- ↑ 1.0 1.1 "Man-Made Brain". Psychology Today. Retrieved 2022-06-28.
- ↑ 2.0 2.1 2.2 2.3 "researchgate.net/profile/Annie-Kathuria-2".
- ↑ "linkedin.com/in/anniekathuria103".
- ↑ "researchgate.net/profile/Annie-Kathuria-2".
- ↑ ""Mini-Brains" Created Stem Cells Studying Biology of Bipolar Disorder". Mass General Advances in Motion. Retrieved 2022-06-28.
- ↑ Kathuria, Annie; Lopez-Lengowski, Kara; Jagtap, Smita S.; McPhie, Donna; Perlis, Roy H.; Cohen, Bruce M.; Karmacharya, Rakesh (2020-07-01). "Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell–Derived Cerebral Organoids in Schizophrenia". JAMA Psychiatry. 77 (7): 745–754. doi:10.1001/jamapsychiatry.2020.0196. ISSN 2168-622X.
- ↑ Kathuria, A.; Nowosiad, P.; Jagasia, R.; Aigner, S.; Taylor, R. D.; Andreae, L. C.; Gatford, N. J. F.; Lucchesi, W.; Srivastava, D. P.; Price, J. "Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development". Molecular Psychiatry. 23 (3): 735–746. doi:10.1038/mp.2017.185. ISSN 1476-5578.
- ↑ Kathuria, Annie; Lopez-Lengowski, Kara; Watmuff, Bradley; McPhie, Donna; Cohen, Bruce M.; Karmacharya, Rakesh (2019-11-28). "Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine". Translational Psychiatry. 9 (1): 1–13. doi:10.1038/s41398-019-0660-x. ISSN 2158-3188.
- ↑ Karmacharya, Rakesh; Watmuff, Bradley; Kathuria, Annie; Liu, Bangyan (2018-04-01). "S193. EX VIVO SIGNATURE OF PSYCHOSIS AND TREATMENT RESPONSE IN PATIENT-DERIVED NEURONS". Schizophrenia Bulletin. 44 (suppl_1): S400–S400. doi:10.1093/schbul/sby018.980. ISSN 0586-7614.
- ↑ PhD, Ruta Nonacs, MD (2020-01-17). "Annie Kathuria, PhD Receives NARSAD Young Investigator Award". MGH Psychiatry News. Retrieved 2022-06-28.
External links
- Annie Kathuria publications indexed by Google Scholar
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