Basem Al-Shayeb
Basem Al-Shayeb is an Egyptian American microbiologist who is a co-founder and the former chief technology officer[1][not in citation given][2] of Amber Bio, a biotechnology startup company in the San Francisco Bay Area which has raised $26 million to develop multi-kilobase RNA editing therapies using CRISPR-Cas.[3][4][5][6]
He received his PhD in microbial biology[7][8] as a National Science Foundation Fellow at the University of California, Berkeley and Innovative Genomics Institute,[9] where he conducted his dissertation work in the lab of Jennifer Doudna, and in the Earth and Planetary Science Department advised by Jillian Banfield.[10] According to ORCID records, he is an active peer reviewer for Nature Portfolio research for several journals including Nature, Nature Communications, and Multidisciplinary Journal of Microbial Ecology (ISME).[7]
During his time at UC Berkeley, he led or was co-first author on publications describing the discovery of the largest known bacteriophages in Nature,[11][12][13][14][15] the smallest CRISPR-Cas genome editing systems in Science and Cell [16][13][17][18][19][20] and a new form of extrachromosomal DNA elements, termed "Borgs," found in methane-oxidizing archaea (Methanoperedens spp.) in Nature.[21][22][23][24][25] Some of the aforementioned CRISPR-Cas enzymes are licensed by Mammoth Biosciences for diagnostic and therapeutic development.[26] He was listed in Forbes 30 Under 30 and Arab America's 30 Under 30 in 2021, [15][27][28] and Forbes All-Star Alumni in 2024 for his scientific discoveries and contributions.[29]
References
- ↑ "Amber Bio". Archived from the original on 2024-05-20. Retrieved 2024-05-25.
- ↑ "Amber Bio". 2024-02-25. Archived from the original on 2024-02-25. Retrieved 2024-08-17.
- ↑ Rice, India. "This Startup Just Raised $26 Million To Develop Safer Gene Editing Tools". Forbes. Retrieved 2024-06-27.
- ↑ "Amber Bio Launches Multi-Kilobase Editing Platform". GEN - Genetic Engineering and Biotechnology News. 2023-08-03. Retrieved 2024-06-27.
- ↑ https://www.businesswire.com/news/home/20230803489484/en/Amber-Bio-Raises-26-Million-Seed-Financing-Co-Led-by-Playground-Global-and-Andreessen-Horowitz-to-Advance-New-RNA-Based-Gene-Editing-Platform
- ↑ "RNA editing start-up Amber Bio launches with $26 million". Chemical & Engineering News. Retrieved 2024-06-27.
- ↑ 7.0 7.1 "ORCID". orcid.org. Retrieved 2024-08-17.
- ↑ "Basem Al-Shayeb". Plant & Microbial Biology | University of California, Berkeley. Retrieved 2024-08-18.
- ↑ "Meet an IGI Scientist: Basem Al-Shayeb". Innovative Genomics Institute (IGI). Retrieved 2022-03-13.
- ↑ "Basem Al-Shayeb | Earth & Planetary Science". eps.berkeley.edu. Retrieved 2024-08-18.
- ↑ York, Ashley (April 2020). "Too big to be ignored". Nature Reviews Microbiology. 18 (4): 192. doi:10.1038/s41579-020-0341-z. ISSN 1740-1534. PMID 32066943 Check
|pmid=value (help). - ↑ Koumoundouros, Tessa (2020-02-13). "Scientists Discover Giant Viruses With Features Only Seen Before in Living Cells". ScienceAlert. Retrieved 2024-08-17.
- ↑ 13.0 13.1 Pausch, Patrick; Al-Shayeb, Basem; Bisom-Rapp, Ezra; Tsuchida, Connor A.; Li, Zheng; Cress, Brady F.; Knott, Gavin J.; Jacobsen, Steven E.; Banfield, Jillian F.; Doudna, Jennifer A. (2020-07-17). "CRISPR-CasΦ from huge phages is a hypercompact genome editor". Science. 369 (6501): 333–337. Bibcode:2020Sci...369..333P. doi:10.1126/science.abb1400. ISSN 0036-8075. PMC 8207990 Check
|pmc=value (help). PMID 32675376 Check|pmid=value (help). - ↑ "Hundreds Of New Viruses With Enormous Genomes Blur The Boundaries Of Life". IFLScience. 2020-02-13. Retrieved 2024-08-17.
- ↑ 15.0 15.1 Knapp, Alex. "30 Under 30 In Science 2021: Building Better Trees, Supernova Simulations And Holograms". Forbes. Retrieved 2024-08-17.
- ↑ "News: Tiny but Mighty: How Researchers Found a New Game-Changing CRISPR Tool". CRISPR Medicine. Retrieved 2024-08-15.
- ↑ Sanders, Robert (2020-07-16). "Megaphages harbor mini-Cas proteins ideal for gene editing". Berkeley News. Retrieved 2024-08-17.
- ↑ "New Compact Genome Editors Found in Viruses". Innovative Genomics Institute (IGI). Retrieved 2024-08-17.
- ↑ "The Little Enzyme That Can: Meet the Gene Editor CasX". Innovative Genomics Institute (IGI). Retrieved 2024-08-17.
- ↑ Al-Shayeb, Basem; Skopintsev, Petr; Soczek, Katarzyna M.; Stahl, Elizabeth C.; Li, Zheng; Groover, Evan; Smock, Dylan; Eggers, Amy R.; Pausch, Patrick; Cress, Brady F.; Huang, Carolyn J.; Staskawicz, Brian; Savage, David F.; Jacobsen, Steven E.; Banfield, Jillian F. (2022-11-23). "Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors". Cell. 185 (24): 4574–4586.e16. doi:10.1016/j.cell.2022.10.020. ISSN 0092-8674. PMID 36423580 Check
|pmid=value (help). - ↑ "Scientists discover Borgs, DNA strands that assimilate genes from their hosts". Chemical & Engineering News. Retrieved 2024-08-17.
- ↑ Al-Shayeb, Basem; Schoelmerich, Marie C.; West-Roberts, Jacob; Valentin-Alvarado, Luis E.; Sachdeva, Rohan; Mullen, Susan; Crits-Christoph, Alexander; Wilkins, Michael J.; Williams, Kenneth H.; Doudna, Jennifer A.; Banfield, Jillian F. (October 2022). "Borgs are giant genetic elements with potential to expand metabolic capacity". Nature. 610 (7933): 731–736. Bibcode:2022Natur.610..731A. doi:10.1038/s41586-022-05256-1. ISSN 1476-4687. PMC 9605863 Check
|pmc=value (help). PMID 36261517 Check|pmid=value (help). - ↑ "Resistance is futile, because Star Trek's Borg are real and can assimilate DNA from microbes". SYFY Official Site. 2021-08-02. Retrieved 2024-08-17.
- ↑ Huang, Lauren (2021-07-19). "UC Berkeley researchers discover unique DNA sequence with potential to combat climate change". www.dailycal.org. Retrieved 2024-08-17.
- ↑ "Previously undiscovered DNA 'borgs' found on California wetlands". The Independent. 2021-07-30.
- ↑ Etherington, Darrell (2020-08-12). "Mammoth Biosciences lands exclusive license to new CRISPR proteins that could boost gene editing precision". TechCrunch. Retrieved 2024-08-18.
- ↑ "Basem Al-Shayeb". Forbes. Retrieved 2022-03-13.
- ↑ "Arab America Foundation Announces 30 Under 30 Awardees-Class of 2021". Arab America. 2021-10-06. Retrieved 2022-10-04.
- ↑ "Forbes 30 Under 30 2024: Science". Forbes. Retrieved 2024-08-17.
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