bit.bio
.png) | |
Formerly | ElpisBioMed |
|---|---|
| Privately held company | |
| ISIN | 🆔 |
| Industry | Synthetic Biology |
| Founded 📆 | |
| Founders 👔 | Mark Kotter |
| Headquarters 🏙️ | , , UK |
Area served 🗺️ | |
Key people | Hermann Hauser (Chairman) |
| Products 📟 | |
| Members | |
Number of employees | |
| 🌐 Website | bit |
| 📇 Address | |
| 📞 telephone | |
bit.bio is a synthetic biology company that is coding cells for novel cures by generating human cells from induced pluripotent stem cells (iPSCs) for drug discovery and cell therapy in regenerative medicine.
Origins[edit]
bit.bio was founded by Mark Kotter in 2016.[1] bit.bio emerged as a spin out of the University of Cambridge to provide human cells for research, drug discovery and cell therapy. [2] Initially named after Elpis the Greek Spirit of Hope, in 2019 the company rebranded as bit.bio, alluding to its application of genetic code (bit) to program biological cells (bio). [3]
In November 2021, Kathryn Penkus Corzo joined bit.bio as president and chief operating officer. Corzo was previously Head of Oncology Cell Therapy Development at Takeda Pharmaceuticals, where she built capabilities and oversaw the oncology cell therapy portfolio including CAR-T, CAR-NK, iPSC and gamma-delta platforms. [4]
In August 2023, bit.bio announced a collaboration with BlueRock Therapeutics (a wholly owned independently operated subsidiary of Bayer AG) to discover and manufacture iPSC-derived regulatory T cells (Tregs) for use in therapeutics. Tregs play a crucial role in maintaining balance in the body’s immune system and controlling excessive immune reactions so iPSC-derived Treg based therapies have the potential to treat a broad range of autoimmune and inflammatory disorders.[5]
In November 2023, bit.bio unveiled its cell therapy pipeline and lead therapeutic candidate (bbHEP01), encapsulated allogeneic txHepatocytes © for the treatment of acute liver failure. By the end of 2023, the company had announced 17 new human iPSC-derived cell products for research and drug discovery in its ioCells © research products portfolio. [6]
In May 2024, the company signed its first project within a multi-year collaboration agreement with The Michael J. Fox Foundation (MJFF) to generate human cell products for research and drug discovery in Parkinson’s disease. [7]
– Mark Kotter, bit.bio (2021)[8]
Raising funds[edit]
In June 2020, it was reported that bit.bio closed a $41.5 million Series A investment, bringing the company’s funding to $50 million. [9]
In November 2021, it was reported that the company raised $103 million in the first close of Series B round of financing. The total raise of the Series B by the end of 2021 amounted to $141.5 million. [10]
The company has raised ca. $200 million in capital from Arch Ventures, Charles River Laboratories, Foresite Capital, Milky Way, National Resilience, Puhua Capital, Tencent and others. [11]
Technology[edit]
bit.bio develops and commercialises the synthetic biology paradigm of forward programming using transcription factors, a form of transdifferentiation, which is rooted in the work of Harold Weintraub, in contrast to stem cell differentiation induced by exposure to culture medium containing cytokines or their inhibitors. [12]In 2023, bit.bio secured a foundational United States patent for opti-ox, its deterministic cell programming technology that uses genomic safe harbour sites. The granted U.S. patent covers the use of opti-ox to deterministically activate genetic code in any eukaryotic (cell with a nucleus) cell type. [13]
References[edit]
- ↑ "Bit Bio Ltd".
- ↑ "Cambridge Judge Business School".
- ↑ "Meet BitBio as cell coding firm retires the Elpis Biomed name". 17 October 2019.
- ↑ "bit.bio appoints Kathryn Corzo as Chief Operating Officer".
- ↑ "BlueRock Therapeutics and bit.bio announce collaboration and option agreement for the discovery and manufacture of regulatory T cell (Treg) based therapies". 3 August 2023.
- ↑ "Bit.bio Introduces Cell Therapy Pipeline, Highlighting Primary Candidate for Acute Liver Failure, and Expands Scientific Advisory Board with International Experts in Cell Therapy".
- ↑ "bit.bio, MJFF to develop human cell products for research in Parkinson's". 8 March 2024.
- ↑ John Cumbers (14 April 2021). "Mark Kotter (bit.bio): 'Meet The Company Reprogramming The Future Of Synthetic Biology'". Forbes. Retrieved 15 July 2024.
- ↑ "Bit Bio's 'enter button for the keyboard to the software of life' nabs the company $41.5 million". 14 June 2020.
- ↑ "Cell therapy startup bit.bio adds $100M+ to its coffers and some impressive names to its board of directors".
- ↑ "Nobel Laureate Thomas Südhof and bit.bio CEO Mark Kotter to Lead Fireside Chat on Programming Human Cells at SynBioBeta". 29 April 2024.
- ↑ "Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes".
- ↑ "bit.bio secures foundational US patent for opti-ox". August 2023.
External links[edit]
This article "Bit.bio" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Bit.bio. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
