Buchler GmbH
Buchler GmbH is a manufacturer of active pharmaceutical ingredients in Brunswick-Wenden in Lower Saxony founded in 1858. The company is the only remaining company of formerly 14 European quinine factories (as of 1958).[1] since the acquisition of the quinine division of DSM in 2001.[2] The company is still owned by the founding family.
Products
The company extracts cinchona alkaloids such as quinine, quinidine, cinchonine and cinchonidine as well as quinic acid from the bark of the cinchona tree. The products are used in the pharmaceutical industry as antimalarials, antiarrhythmics or against nocturnal leg cramps, as a bittering agent in the food industry, e.g. for tonic water or bitter lemon and as a racemic resolution agent or chiral ligand in the fine chemical industry.[3]
Company
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The Austrian-German entrepreneur Hermann Buchler founded a chemical factory in 1858 under the name Hermann Buchlers Chininfabrik (quinine factory). It initially produced the alkaloids quinine and cocaine for pharmaceutical purposes and exported them worldwide. A successful research by chemist Friedrich Oskar Giesel who joined the company in 1878, enabled the company to develop the world's first industrial radium[4] extraction process in 1898. This process allowed radium bromide to be produced on an industrial scale. The majority of the Radiopharmaceuticals division was sold to GE Healthcare in 1971 (later Amersham Buchler GmbH & Co. KG). The company still exists under the name GE Healthcare Buchler GmbH & Co. KG as the German Medical Diagnostics Division of GE Healthcare.[5]
After almost complete destruction by the bombing of Brunswick on October 15, 1944,[6] and reconstruction at the old site, the production of radioactive isotopes, which was later taken up, resulted in the relocation of the production facility from Brunswick City to Brunswick-Wenden. From 1971 to 1990, the production was steadily relocated.[1] The demolition of the old factory facilities on Frankfurter Strasse began in 1988.
The production of pills was terminated in 1989. Since then, only APIs are isolated and sold as sulfate, hydrochloride, gluconate, benzoate or chemical base.
Buchler was involved in the second quinine cartel from 1958 until 1963 which was punished by the European Commission in 1969.[7]
Earlier Products
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Products of Buchler GmbH which were produced until 1989 -
Product packaging of Buchler GmbH from 1963 -
Original products of chinin factory Brunswick
External Links
- Commons: Buchler (Unternehmen) – collection of images, videos and audio files
- Website of Buchler GmbH with company history
References
- ↑ 1.0 1.1 Thomas W. Buchler: 150 Jahre Chininfabrik Braunschweig (150 Years Chinin Factory Brunswick)
- ↑ "Notification of the Spanish Competition Authority". Comisión nacional de los mercados y la competencia. Retrieved 26 January 2021. Unknown parameter
|url-status=ignored (help) - ↑ Prof. Choong Eui Song (2 December 2009). Cinchona Alkaloids in Synthesis and Catalysis: Ligands, Immobilization and Organocatalysis. Wiley‐VCH Verlag GmbH & Co. KGaA. ISBN 978-3-527-32416-3. Search this book on
- ↑ "Friedrich Oskar Giesel". Braunschweig.de - Tourismus und Kongresse. Retrieved 6 January 2009. Unknown parameter
|url-status=ignored (help) - ↑ GE Healthcare Radiopharmaka Abgerufen am 26. Februar 2021.
- ↑ Rudolf Prescher: Der rote Hahn über Braunschweig. Luftschutzmaßnahmen und Luftkriegsereignisse in der Stadt Braunschweig 1927 bis 1945, Braunschweig 1955, p. 88.
- ↑ Decision of the European Commission (only available in French, Italian, German (5 August 1969). "DÉCISION DE LA COMMISSION du 16 juillet 1969 relative à une procédure au titre de l'article 85 du traité (IV/26.623 - Entente internationale de la quinine) (Les textes allemand, français et néerlandais sont les seuls faisant foi) (69/240/CEE)". Official Journal of the European Communities. 192 (69/240/EWG): 5–22. Retrieved 24 February 2021.CS1 maint: Multiple names: authors list (link)
Bibliography
- Walther Buchler (Hrsg.): 300 Jahre Buchler. Die Unternehmen einer Familie 1651–1958. Braunschweig 1958.
- Jörg Leuschner, Karl Heinrich Kaufhold, Claudia Märtl (Hrsg.): Die Wirtschafts- und Sozialgeschichte des Braunschweigischen Landes vom Mittelalter bis zur Gegenwart. Band 3: Neuzeit. Georg Olms Verlag, Hildesheim 2008, ISBN 978-3-487-13599-1, p. 207–208.
- Bernd Rother: Buchler (Firma). In: Luitgard Camerer, Manfred Garzmann, Wolf-Dieter Schuegraf (Hrsg.): Joh. Heinr. Meyer Verlag, Brunswick 1992, ISBN 3-926701-14-5, p. 49.
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