|buspirone||serotonin receptor agonist|
|L-DOPA||nucleoside analog reverse transcriptase inhibitor|
The drug combination Buspirone/L-DOPA/carbidopa (trade name Spinalon) is an experimental tri-therapy for the the treatment of chronic spinal cord injury. It is a proprietary fixed-dose combination product discovered by Prof Dr Pierre A. Guertin in 2005 that is being developed clinically since 2012 as an activator of the central pattern generator for locomotion in patients with paraplegia or tetraplegia.
Two clinical trials are registered on clinicaltrials.com:
In 2017, Nordic Life Science Pipeline and Prof Dr Pierre A. Guertin found no evidence of safety concerns below the maximum tolerated dose following a single administration of buspirone/L-DOPA/carbidopa in forty-five volunteers suffering a chronic spinal cord injury classified as complete (AIS A) or motor-complete (AIS B)(NCT01484184). Some locomotor-like activity in the legs of those who received the experimental therapy, but not in those who received a placebo, was also reported.
In 2019, Jocelyne Bloch from the Centre Hospitalier Universitaire Vaudois announced a clinical study aimed at examining the safety and preliminary efficacy of buspirone/L-DOPA/carbidopa in volunteers with chronic spinal cord injuries (NCT04052776) as a complementary approach to epidural stimulation being developed for commercial purposes by Grégoire Courtine, the chief scientific officer of GTX Medical.
Note[edit | edit source]
The clinical development of buspirone/L-DOPA/carbidopa in Switzerland by the co-founder of GTX Medical has not obtained legal authorizations nor licensing agreements from the inventor and/or the licensor.
References[edit | edit source]
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