CCDC178
CCDC178
Coiled-coil Domain Containing 178 (CCDC178) is a protein that in humans is encoded by the CCDC178 gene. CCDC178 is also known as C18orf34. It is found on chromosome 18 and spans 503634 nucleotides.[1]. Homologous CCDC178 genes are only found in jawed vertebrates excluding lungfish. This includes cartilaginous fish, ray-finned fish, coelacanths, amphibians, reptiles, mammals and birds[2].
Gene
CCDC178 is found on the minus strand of chromosome 18 (18q12.1) and spans bases 33,441,040 to 32,937,406[1]. There are five known variants of its mRNA with the longest containing 24 exons. These five variants code three isoforms of CCDC178.The transcripts that produce isoform 1 do not include an alternative in-frame exon in the 3′ coding region. Those that generate isoform 2 differ at the 5′ untranslated region and also omit two alternative in-frame exons within the coding sequence.[1].
| Transcript Accession | Transcript Length (nt) | Protein Accession | Protein Length (aa) | Isoform |
|---|---|---|---|---|
| NM_001105528.4 | 3420 | NP_001098998.1 | 867 | 1 |
| NM_198995.3 | 3325 | NP_945346.2 | 829 | 2 |
| NM_001308126.3 | 3511 | NP_001295055.1 | 891 | 3 |
| NM_001371120.1 | 3513 | NP_001358049.1 | 891 | 3 |
| NM_001371121.1 | 3522 | NP_001358050.1 | 891 | 3 |
Protein
CCDC178 has a calculated molecular weight of 104.621 kDa and a predicted isoelectric point of 6.34 pI[3]. The protein exhibits a high density of both positively and negatively charged residues like lysine and glutamic acid respectively resulting in a slight net negative charge at standard pH, but a highly polar surface.
Evolutionary History
Orthologs of CCDC178 are found across all major groups of jawed vertebrates, including species of cartilaginous fish, ray-finned fish, amphibians, reptiles, birds, and mammals. Among lobe-finned fish, the gene has only been identified in the coelacanth, while it appears to be absent in other extant members of this lineage[2]. CCDC178 has no known paralogs in humans[4]. CCDC178 is observed to have a rapid rate of mutation.
Clinical Significance
CCDC178 has been shown to be upregulated in hepatocellular carcinoma tissues. It additionally promotes the degradation of BRAP2, can confer anoikis resistance and activate the ERK pathway[5]. CCDC178 was found to also induce the ERK pathway in gastric cancer[6]
- ↑ 1.0 1.1 1.2 "CCDC178 coiled-coil domain containing 178 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2025-07-30.
- ↑ 2.0 2.1 "CCDC178 orthologs". NCBI. Retrieved 2025-07-30.
- ↑ "Expasy - ProtParam". web.expasy.org. Retrieved 2025-07-30.
- ↑ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2025-07-30.
- ↑ Hu, X.; Zhao, Y.; Wei, L.; Zhu, B.; Song, D.; Wang, J.; Yu, L.; Wu, J. (2017-07-13). "CCDC178 promotes hepatocellular carcinoma metastasis through modulation of anoikis". Oncogene. 36 (28): 4047–4059. doi:10.1038/onc.2017.10. ISSN 1476-5594. PMID 28319061.
- ↑ Gu, Yue; Chen, Gang; Ning, Xinwei (2024-04-15). "Homeobox Protein BarH-like 1 Promotes Gastric Cancer Progression by Activating Coiled-Coil Domain-Containing Protein 178". Digestive Diseases and Sciences. 69 (4): 1182–1199. doi:10.1007/s10620-024-08312-0. ISSN 1573-2568. PMID 38358459 Check
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