CONTINUUS Pharmaceuticals
| Formation | 2012 |
|---|---|
| Founder | Salvatore Mascia |
| Type | Private |
| Headquarters | Woburn, MA |
| Location |
|
Staff | 20 - 30 |
| Website | continuuspharma.com |
CONTINUUS Pharmaceuticals Inc. is an American pharmaceutical company located in Woburn, MA.
CONTINUUS was founded in 2012 by Salvatore Mascia. The company is a spin-out of the Novartis-MIT center for continuous manufacturing. Its core business is enabling end-to-end Integrated Continuous Manufacturing, applying novel technologies to enable continuous production of pharmaceuticals at reduced costs and higher quality.[1]
The company moved to its current Headquarters in Woburn in April 2015.[2]
On-Demand Manufacturing of Pharmaceuticals
CONTINUUS Pharmaceuticals aims to change the manufacturing environment from a batch production, that follows a step-by-step process, to a continuous one that allows continuous-flow manufacturing. The technology developed by the company is focused on the transition from batch to flow of small molecule pharmaceuticals.
Funding
CONTINUUS supported its incorporation with debt financing, for a total of $265,000[3]. The second source of financing was provided by MassChallenge in 2013[4] in the form of a grant (the size of the grant was not disclosed), and the last round was financed by IMA, an Italian company specialized in design and manufacturing, that invested $2,463,659 in the company.
The company has also been funded by the National Science Foundation, that has awarded two grants to Continuus, the first one for $150,000[5] (SBIR Phase I: Novel pharmaceutical manufacturing technologies to deliver more affordable medications to patients faster and with better quality) and the second one for $1,258,000.00[6] (SBIR Phase II: Novel pharmaceutical manufacturing technologies to deliver more affordable medications to patients faster and with better quality).
Products
Targeted Solutions
Single unit of operations designed to work continuously:
| Name | Function | Description |
|---|---|---|
| Continuous Reactor | Reaction | Reactor designed to handle solids in continuous flow, developed for fast exothermic reactions. |
| Membrane Separator By-Pass | Filtration | System that allows cleaning in place of a membrane separator, allowing separation between organic and aqueous streams. |
| Continuous Rotary Filter | Filtration | Rotary filtration and washing system for the filtration of suspensions containing API or intermediates. |
| Extrusion Molding Coating | Drug Product | Integrated continuous machine, fed with API releases coated tablets operating solvent free. |
| Integrated Nucleator and Tubular Crystallizer | Crystallization | Device to produce particles with mono-disperse, very narrow size distribution by running a supersaturated solution into the device containing specific seeds to initiate the nucleation process. |
| Thin Film / Electrospinning | Drug Product | Process for manufacturing solid oral dosage from solutions of purified API. |
| Continuous Drum Dryer | Drying | Drum dryer, it extracts dry powder from a suspension that contains the API continuously. |
| Heterogeneous Crystallization | Crystallization | Process to crystallize the API directly on the excipient surface. |
Integrated Continuous Manufacturing
End to end process, starting from raw materials to the final drug product.
Continuous manufacturing (CM) can be accomplished in a production area that is about one-tenth the size of a traditional pharmaceutical manufacturing facility—at about 40% of the cost.[7]
References
- ↑ Research, Center for Drug Evaluation and. "News & Events - Modernizing the Way Drugs Are Made: A Transition to Continuous Manufacturing". www.fda.gov. Retrieved 2018-11-16.
- ↑ "CONTINUUS PHARMACEUTICALS OPENS NEW FACILITY IN WOBURN" (PDF). Massachusetts Life Sciences Center. April 2015.
- ↑ "SEC FORM D".
- ↑ "MassChallenge names 2013 finalists - full list of 128 startups". www.bizjournals.com. Retrieved 2018-11-21.
- ↑ "NSF Award Search: Award#1447944 - SBIR Phase I: Novel pharmaceutical manufacturing technologies to deliver more affordable medications to patients faster and with better quality". www.nsf.gov. Retrieved 2018-11-26.
- ↑ "NSF Award Search: Award#1555647 - SBIR Phase II: Novel pharmaceutical manufacturing technologies to deliver more affordable medications to patients faster and with better quality". www.nsf.gov. Retrieved 2018-11-26.
- ↑ "https://www.pharmacypracticenews.com/Policy/Article/09-18/Want-to-stop-drug-shortages-Think-Inside-The-Box-/52631?sub=56B58C879BB7D26743785DB8565711AF7774A3B8B327AB44E424A1534AD8E&enl=true". www.pharmacypracticenews.com. Retrieved 2018-11-26. External link in
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