Cardioinformatics
Cardioinformatics is an interdisciplinary field that applies bioinformatics and computational biology methods and software tools to cardiovascular disease data storage, computing, and analysis[1]. It is formally defined as the nexus of bioinformatics and precision cardiology,[2] a subset of precision medicine.
Introduction
Cardioinformatics involves the administration and analysis of biomedical data pertaining to precision cardiovascular medicine[3], although it also finds concrete applications in cardiorenal and cardiometabolic disease[4], such as the development of data commons and knowledge bases for investigating chronic kidney disease, diabetes, metabolic syndrome, among other disease phenotypes and medical comorbidities relevant to the pathophysiology of the cardiovascular system (e.g., atherosclerosis, cardiomyopathy, heart failure, etc.). Examples of such cardioinformatics resources include NHLBI's BioData Catalyst[5], American Heart Association's Precision Medicine Platform[6], Broad Institute's Human Genetics Amplifier[7], and Stanford/UChicago's HeartBioPortal[8].
History
Historically, the term cardioinformatics originated at Stanford University and University of Chicago, first appearing in print in the journal Briefings in Bioinformatics in 2019[9]. The term appears to be originally coined by Bohdan Khomtchouk, the first and corresponding author of the aforementioned publication, during his time as an American Heart Association Postdoctoral Fellow at Stanford University School of Medicine (Division of Cardiovascular Medicine) and then faculty member at the University of Chicago Medical Center (Section of Computational Biomedicine and Biomedical Data Science).
References
This article "Cardioinformatics" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Cardioinformatics. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
- ↑ https://grahamschool.uchicago.edu/events/msc-biomedical-informatics/cardioinformatics-and-its-impact-healthcare/may-13-2020
- ↑ Khomtchouk, B. B.; Tran, D. T.; Vand, K. A.; Might, M.; Gozani, O.; Assimes, T. L. (2019). "Cardioinformatics: the nexus of bioinformatics and precision cardiology". Briefings in Bioinformatics. bbz119 (6): 2031–2051. doi:10.1093/bib/bbz119. PMID 31802103.
- ↑ https://www.uchicagomedicine.org/forefront/heart-and-vascular-articles/research-sets-sights-on-heart-disease-discoveries-through-precision-cardiology-and-bioinformatics
- ↑ Khomtchouk, Bohdan; Nelson, Christopher S.; Vand, Kasra A.; Palmisano, Salvator; Grossman, Robert L. (2020-12-31). "HeartBioPortal2.0: new developments and updates for genetic ancestry and cardiometabolic quantitative traits in diverse human populations". Database. 2020. doi:10.1093/database/baaa115. PMC 7774463 Check
|pmc=value (help). PMID 33382884 Check|pmid=value (help). - ↑ https://biodatacatalyst.nhlbi.nih.gov/
- ↑ https://precision.heart.org/
- ↑ https://www.kp4cd.org/
- ↑ Khomtchouk, B. B.; Vand, K. A.; Koehler, W. C.; Tran, D. T.; Middlebrook, K.; Sudhakaran, S.; Nelson, C. S.; Gozani, O.; Assimes, T. L. (2019). "HeartBioPortal: An Internet-of-Omics for Human Cardiovascular Disease Data". Circulation: Genomic and Precision Medicine. 12 (4): e002426. doi:10.1161/CIRCGEN.118.002426. PMC 6637758 Check
|pmc=value (help). PMID 31294639. - ↑ Khomtchouk, B. B.; Tran, D. T.; Vand, K. A.; Might, M.; Gozani, O.; Assimes, T. L. (2019). "Cardioinformatics: the nexus of bioinformatics and precision cardiology". Briefings in Bioinformatics. bbz119 (6): 2031–2051. doi:10.1093/bib/bbz119. PMID 31802103.
