Care222
Care222 is the light source device for sterilization developed by Columbia University and Ushio Inc., a Japanese industrial machinery manufacturer. It has been proven to be effective in inactivating COVID-19 virus. It combines a far UV-C excimer lamp that emits ultraviolet light (wavelength 222nm), which is suitable for sterilization, with a filter that limits the light to only the wavelength range that is harmless to the human body (200-230 nm). The name is registered as a trademark by Ushio America, Inc, a group company of Ushio Inc.
Overview
Care222 is an ultraviolet germicidal light source that is harmless to the human body and can directly irradiate to sterilize air and surfaces of materials in areas where people are present.
In August 2020, Kobe University Graduate School of Medicine verified the effects of Care222 on human skin and eyes, and confirmed the safety of Care222 with healthy testers.[1]
Further, in September 2020, a peer-reviewed paper was published by Hiroshima University, which shows 99.7% inactivation of SARS-CoV-2 (so-called COVID-19) in 30 seconds.[2]
Sterilizing effect
The verification on irradiation of SARS-CoV-2 was announced on September 4, 2020 by a research group at Hiroshima University, which showed that 88.5% of the virus was inactivated after 10 seconds of irradiation with far-ultraviolet UV-C 222nm at 0.1 mW/cm2, and 99.7% after 30 seconds of irradiation.[2]
Required disinfection dose = disinfection illuminance x irradiation time
In addition to SARS-CoV-2, it can also be used to sterilize basically all viruses and bacteria, including influenza virus, Ebola virus, O-157 E. coli, typhoid bacillus, and salmonella.[3]
UV sterilization is also believed to be effective against the currently discussed SARS-CoV-2 variant.[3]
Safety
As UV-C has stronger germicidal power than UV-A and UV-B, the development of UV excimer fluorescent lamps, which emit UV-C 222nm light, began with the assumption that they would be used for medical purposes.
The UV-C 222nm light has a sterilizing capability comparable to that of the currently popular UV-C 254nm light,[4]and is harmless to the human body, which has been reported by various research institutes.[5]
In general, conventional UV light reaches the lowest layer of the skin, the basal layer of the epidermis, and damages the DNA of the cells.
In contrast, UV-C at 222nm reaches only the stratum corneum, the outer surface layer of the skin (which would become plaque), and does not damage the DNA of epidermal cells.[6]
In addition, as the corneal permeation rate of UV-C 222nm was less than 0.01%, and no corneal epithelial damage was observed, it was proved that it does not cause eye diseases such as cataracts.[7]
A special optical band-pass filter developed by David Brenner, director of the Radiation Laboratory at Columbia University in the U.S., and his collaborators, played a major role in this.
Research Reports on the Effectiveness of Care222
Care222 has been studied and proven effective by several institutions including Columbia University[8][9], Kobe University[10][5], Hiroshima University[11][12], and Harvard University[13]
In addition, the world's largest scientific journal, Scientific Reports, has evaluated the disinfection performance and safety of Care222[14], and the open access scientific medical journal, PLOS ONE, has announced that UV-C 222nm light "is a safe irradiation that is expected to contribute to the prevention of infections in the future.[15]
Theodore Read
In 2012, Columbia University (located in New York City, U.S.A.) obtained a patent for a technology that combines a light source emitting light at wavelengths including 222nm with a filter that shields harmful wavelengths from the light source, thereby irradiating only ultraviolet wavelengths (200-230nm) that are harmless to the human body.
Ushio Electric Inc. has the exclusive worldwide rights to the patent.[16]
References
- ↑ "222nm紫外線の人体皮膚への安全性と殺菌効果の両立を立証 ― これまでにない、新たな感染症予防・治療法開発へ ―". Research at Kobe (in 日本語). Retrieved 2021-02-04.
- ↑ 2.0 2.1 Kitagawa, Hiroki; Nomura, Toshihito; Nazmul, Tanuza; Omori, Keitaro; Shigemoto, Norifumi; Sakaguchi, Takemasa; Ohge, Hiroki (2020-09-04). "Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination". American Journal of Infection Control. 49 (3): 299–301. doi:10.1016/j.ajic.2020.08.022. ISSN 0196-6553. PMC 7473342 Check
|pmc=value (help). PMID 32896604 Check|pmid=value (help). - ↑ 3.0 3.1 "原理 | 殺菌 | ウシオの環境衛生" (in 日本語). Retrieved 2021-02-04.
- ↑ "効果 | 殺菌 | ウシオの環境衛生" (in 日本語). Retrieved 2021-02-04.
- ↑ 5.0 5.1 "皮膚がんなどの発症なし 222nm紫外線（UV-C）繰り返し照射の安全性を世界で初めて実証". Research at Kobe (in 日本語). Retrieved 2021-02-04.
- ↑ "特長 | 殺菌 | ウシオの環境衛生" (in 日本語). Retrieved 2021-02-04.
- ↑ "島根大学医学部眼科学講座". www.med.shimane-u.ac.jp. Retrieved 2021-02-04.
- ↑ "Far-UVC Light Safely Kills Airborne Coronaviruses". Columbia University Irving Medical Center. 2020-06-24. Retrieved 2021-02-04.
- ↑ Buonanno, Manuela; Welch, David; Shuryak, Igor; Brenner, David J. (2020-06-24). "Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses". Scientific Reports. 10 (1): 10285. Bibcode:2020NatSR..1010285B. doi:10.1038/s41598-020-67211-2. ISSN 2045-2322. PMC 7314750 Check
|pmc=value (help). PMID 32581288 Check|pmid=value (help). Unknown parameter|s2cid=ignored (help) - ↑ "ウシオ電機と神戸大、222nm紫外線の人体皮膚への安全性と殺菌効果の両立を立証". 日本経済新聞 (in 日本語). 2020-08-13. Retrieved 2021-02-04.
- ↑ "波長222nm紫外線が新型コロナウイルスを不活化する効果を発見～感染対策への応用へ期待～ (動画あり)". www.hiroshima-u.ac.jp (in 日本語). Retrieved 2021-02-04.
- ↑ "広島大学における新型コロナウイルスに対する研究状況について～AMEDウイルス等感染症対策技術開発事業へ採択されました～". www.hiroshima-u.ac.jp (in 日本語). Retrieved 2021-02-04.
- ↑ Narita, Kouji; Asano, Krisana; Morimoto, Yukihiro; Igarashi, Tatsushi; Hamblin, Michael R.; Dai, Tianhong; Nakane, Akio (January 2018). "Disinfection and healing effects of 222-nm UVC light on methicillin-resistant Staphylococcus aureus infection in mouse wounds". Journal of Photochemistry and Photobiology B: Biology. 178: 10–18. doi:10.1016/j.jphotobiol.2017.10.030. ISSN 1873-2682. PMC 5771808. PMID 29101868.
- ↑ Welch, David; Buonanno, Manuela; Grilj, Veljko; Shuryak, Igor; Crickmore, Connor; Bigelow, Alan W.; Randers-Pehrson, Gerhard; Johnson, Gary W.; Brenner, David J. (2018-02-09). "Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases". Scientific Reports. 8 (1): 2752. Bibcode:2018NatSR...8.2752W. doi:10.1038/s41598-018-21058-w. ISSN 2045-2322. PMC 5807439. PMID 29426899.
- ↑ Fukui, Tomoaki; Niikura, Takahiro; Oda, Takahiro; Kumabe, Yohei; Ohashi, Hiroyuki; Sasaki, Masahiro; Igarashi, Tatsushi; Kunisada, Makoto; Yamano, Nozomi; Oe, Keisuke; Matsumoto, Tomoyuki (2020-08-12). "Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans". PLOS ONE. 15 (8): e0235948. Bibcode:2020PLoSO..1535948F. doi:10.1371/journal.pone.0235948. ISSN 1932-6203. PMC 7423062 Check
|pmc=value (help). PMID 32785216 Check|pmid=value (help). - ↑ "Care222®とは？ | 殺菌 | ウシオの環境衛生" (in 日本語). Retrieved 2021-02-04.
External Links
- Ushio America, Inc official[1]
- Care222 LED Lamp https://www.faruvclite.com/
- Ushio Care222 Filtered Far UV-C Excimer[2]
- TED talk by collaborator David Brenner, Director of the Radiation Laboratory at Columbia University[3]
This article "Care222" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Care222. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
- ↑ "Ushio America, Inc". www.ushio.com. 2018-06-12. Retrieved 2021-02-04.
- ↑ "care222 - Bing video". www.bing.com. Retrieved 2021-02-04.
- ↑ Brenner, David. "Transcript of "A new weapon in the fight against superbugs"". www.ted.com. Retrieved 2021-02-04.
