Channelomics
Channelomics is the term for the study of membrane channels, that is; ion channels and porins (the "channelome"). It is therefore a branch of physiology, biophysics and pharmacology. Channelomics particularly includes study of the gene expression, structure and function of ion channels.
Structural studies[edit]
Structure and functional studies of membrane channels are closely linked, but perhaps the most famous recent work studying the structure of ion channels is the paper by Doyle et al. 1998, which led to the Nobel Prize for physiology for Prof Roderick MacKinnon.
Functional studies[edit]
There are a vast array of studies investigating the function of "membrane channels", these frequently combine patch clamp electrophysiology with pharmacology. The process by which membrane channel function is altered by drugs and biochemicals is termed "channel modulation". Functional channelomic studies also includes study of diseases resulting from their mis-function. Such a disease is termed a channelopathy.
Technologies[edit]
In principle, channelomics uses most of technologies of biochemistry or proteomics; however, perhaps the most important technology used almost exclusively for channelomics is the patch clamp branch of electrophysiology.
References[edit]
The term "Channelomics" has been used by many authors including:
Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.nurt.2007.01.013, please use {{cite journal}} with |doi=10.1016/j.nurt.2007.01.013 instead.
Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1136/jnnp.74.11.1466, please use {{cite journal}} with |doi=10.1136/jnnp.74.11.1466 instead.
Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.2174/1389201043376715, please use {{cite journal}} with |doi=10.2174/1389201043376715 instead.
Information about ion channels can be found in these papers:
Ion channel structure: Doyle, D. A., Morais-Cabral, J., Pfuetzner, R. A., Kuo, A, Gulbis, JM, Cohen, SL, Chait, BT, MacKinnon, R (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280:69-77.
Porin Structure: Preston GM, Carroll TP, Guggino WB, Agre P (1992). Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 256(5055): 385-387
Channelopathy: Jurkat-Rott,K; Lehmann-Horn, F. (2004). The Patch Clamp Technique in Ion Channel Research. Current Pharmaceutical Biotechnology, 5(4):387-395.
This article "Channelomics" is from Wikipedia. The list of its authors can be seen in its historical. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
