CRIO
| Private | |
| ISIN | 🆔 |
| Industry | Clinical research, Health technology |
| Founded 📆 | 2015[1] |
| Founder 👔 | Raymond Nomizu, Phuc Truong[1][2] |
Area served 🗺️ | |
Key people | Raymond Nomizu (Co-CEO), Jonathan Andrus (Co-CEO)[3] |
| Products 📟 | eSource, CTMS, eRegulatory[3] |
| Owner | The Riverside Company[4][5] |
| Members | |
Number of employees | |
| 🌐 Website | clinicalresearch |
| 📇 Address | |
| 📞 telephone | |
CRIO (Clinical Research IO) is an American health technology company that develops software for the clinical trial industry.[7] Headquartered in Boston, Massachusetts, the company provides cloud-based platforms, including electronic source data capture (eSource), Clinical Trial Management Systems (CTMS), and electronic regulatory management (eRegulatory) software, primarily used by research sites, clinical sponsors, and contract research organizations (CROs).[3][8]
History
CRIO was founded in 2015 by Raymond Nomizu and Phuc Truong with the goal of replacing paper-based documentation systems in clinical trials with direct-to-digital data capture tools.[1][2] Between 2016 and 2024, the company raised approximately $17 million in venture funding, supported by institutional investors including Abbhi Capital, NXT Ventures, Rally Ventures, and Boston Millennia Partners.[9][10]
In 2021, the company expanded its enterprise offerings by launching a centralized eSource system designed to allow pharmaceutical sponsors and CROs to standardize digital protocol templates across multiple global research sites.[7][3]
In 2024, global private equity firm The Riverside Company acquired an investment stake in CRIO through its Riverside Micro-Cap Fund to accelerate product development and scale international operations.[11][12]
In 2025 and 2026, CRIO collaborated with the Tufts Center for the Study of Drug Development (CSDD) on a global research study evaluating bottlenecks and inefficiencies in the protocol-guided source document preparation process across clinical trial sites.[13][14]
In 2026, the company established a strategic partnership with Medidata to integrate its site-level eSource platform directly into the Medidata Electronic Data Capture (EDC) environment, enabling automated data transfer across more than 2,500 research sites globally. [15] The same year, CRIO partnered with the Site Accreditation and Standards Institute (SASI) to release a real-world clinical trial benchmarking initiative based on operational data from nearly 2,900 research sites. The study analyzed trial startup efficiency, enrollment throughput, and revenue metrics across site cohorts.[16]
Products
The company's software suite is designed to digitize site-level workflows and regulatory compliance:[3]
- eSource: An electronic system that allows clinical researchers to capture patient data directly onto digital forms during study visits.[7][3]
- CTMS: Software used by research sites to manage operations, patient recruitment, scheduling, and site financial accounts.[3][8]
- eRegulatory: A digital binder management platform designed to maintain compliance with FDA 21 CFR Part 11 and HIPAA standards.[3][8]
- eConsent: Software that integrates with eSource platforms to automate informed consent form (ICF) management.[17]
- Central eSource: Software that standardizes electronic data collection across clinical trial sites using uniform templates. This enables automated data transfer from the eSource platform directly into the Electronic Data Capture (EDC) system, eliminating manual transcription.[18][19]
Regulatory compliance
CRIO's systems are built to comply with global regulatory frameworks for clinical data integrity, including the United States Food and Drug Administration's regulations on electronic records and electronic signatures (21 CFR Part 11), General Data Protection Regulation (GDPR), Health Insurance Portability and Accountability Act (HIPAA), and Good Clinical Practice (GCP) standards as outlined by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH).[3][9]
References
- ↑ 1.0 1.1 1.2 "About CRIO". CRIO. Retrieved 5 September 2026.
- ↑ 2.0 2.1 "Crio - Activity, founders and funding". UnicornAlert. Retrieved 5 September 2026.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 "CRIO Company Profile". Himalayas. Retrieved 5 September 2026.
- ↑ "The Riverside Company Makes Breakthrough Investment in CRIO, Inc". The Riverside Company. Retrieved 12 September 2026.
- ↑ "Riverside Company backs eClinical technology provider CRIO, Inc". PE Hub. Retrieved 12 September 2026.
- ↑ "CRIO Company Profile". Growjo. Retrieved 5 September 2026.
- ↑ 7.0 7.1 7.2 "About CRIO". CRIO. Retrieved 5 September 2026.
- ↑ 8.0 8.1 8.2 "CRIO Company Profile & Funding". Tracxn. 20 July 2026. Retrieved 5 September 2026.
- ↑ 9.0 9.1 "CRIO Venture Capital and Private Equity Financings". VC News Daily. 12 January 2022. Retrieved 5 September 2026.
- ↑ "CRIO - Funding Rounds & List of Investors". Tracxn. 20 July 2026. Retrieved 5 September 2026.
- ↑ "The Riverside Company Makes Breakthrough Investment in CRIO, Inc". The Riverside Company. Retrieved 12 September 2026.
- ↑ "Riverside Company backs eClinical technology provider CRIO, Inc". PE Hub. Retrieved 12 September 2026.
- ↑ Harper, Beth; Ford, Ruby Madison. "Characterizing the Protocol-Guided Source Preparation Process at Investigative Sites". Applied Clinical Trials Online. Retrieved 12 September 2026.
- ↑ "Medidata and CRIO Empower Over 2,500 Global Research Sites with Seamless Integration to Accelerate Clinical Trials". Globe News Wire. Retrieved 12 September 2026.
- ↑ Studna, Andy. "Medidata, CRIO Partnership Advances eSource Integration to Improve Data Quality and Trial Efficiency". Applied Clinical Trials Online. Retrieved 12 September 2026.
- ↑ "CRIO Benchmark Reveals Clinical Trial Site Revenue Is Built on Operational Scale, Not Pricing Alone". Trial Site News. Retrieved 12 September 2026.
- ↑ "eConsent". CRIO. Retrieved 12 September 2026.
- ↑ "Central eSource". CRIO. Retrieved 12 September 2026.
- ↑ Schell, Dan. "The Dream Is EHR-To-EDC — eSource Is The Wake-Up Call". Clinical Leader. Retrieved 12 September 2026.
External links
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