ERICH6
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ERICH6 is a gene that encodes for the glutamate-rich 6 protein..[1]. In humans, it is found in the 44th open reading frame of the 3rd chromosome[2].
Gene
Locus
ERICH6 is a protein-coding gene found on the reverse (-) strand of chromosome 3 at the locus 3q25.1, on the long arm of the chromosome[3]
Gene Neighborhood
The SIAH2 gene is located upstream of ERICH6 on the third chromosome. Additionally, the SELENOT gene is located downstream.[citation needed]
Aliases
ERICH6 is also known as c3orf44, FAM194A and ERICH6A.[citation needed]
Transcript
mRNA
ERICH6's mRNA transcript is 2021 nucleotides long. These nucleotides encode for a 663 amino acid protein. There are 14 exons and 13 introns, as well as two isoforms. Isoform 1 is the longer, with isoform 2 missing exon 1.[citation needed]
Protein
The protein encoded by ERICH6 is known as glutamate-rich 6 protein. The molecular weight of glutamate-rich 6 is about 75kD[4]. There are two disordered regions within the protein. The protein contains a FAM194 region, which is highly conserved.[citation needed]
Expression
ERICH6 is expressed at low levels throughout the body[5]. The expression pattern of this protein is restricted to pre-meiotic germ cells, which suggests it could be implicated in cell division or DNA replication during the early stages of spermatogenesis[6]
Homology
Paralogs
There are two known paralogs of ERICH6. ERICH6B is located on Chromosome 13 while c3orf20 is on Chromosome 3.[citation needed]
| Name | Accesion Number | Location in human genome | Sequence similarity to ERICH6 | E-value |
|---|---|---|---|---|
| ERICH6B | NP_872348 | c13 q14.13 | 32.6% | 8.00E-20 |
| c3orf20 | AAH30599.1 | c3 p25.1 | 29.93% | 3.00E-12 |
Orthologs
ERICH6 was found to be conserved in all mammals, reptiles, fish and most invertebrates[7]. The most distance ortholog was found to evolve 758 million years ago[8]. It was not found in any arthropods.
Gene Evolution
ERICH6 is relatively fast evolving. It has evolution values (corrected M) more similar to the quick evolving Fibrinogen alpha chain gene. It is quicker evolving than the Cytochrome c gene.[citation needed]
Clinical Significance
ERICH6 as a lncRNA has a strong correlation with Immune cell infiltration[9]. Mutations in the 5' UTR of ERICH6 (T to C switches) were found to cause tumor regression in Tasmanian Devils[10]
References
- ↑ "ERICH6 glutamate rich 6 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-20.
- ↑ "glutamate-rich protein 6 isoform 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-20.
- ↑ GeneCards Human Gene Database. "ERICH6 Gene - GeneCards | ERIP6 Protein | ERIP6 Antibody". www.genecards.org. Archived from the original on 2021-11-22. Retrieved 2025-01-20. Unknown parameter
|url-status=ignored (help) - ↑ "SAPS Protein Analysis". www.ebi.ac.uk. Retrieved 2024-12-11.
- ↑ Fagerberg, Linn; Hallström, Björn M.; Oksvold, Per; Kampf, Caroline; Djureinovic, Dijana; Odeberg, Jacob; Habuka, Masato; Tahmasebpoor, Simin; Danielsson, Angelika; Edlund, Karolina; Asplund, Anna; Sjöstedt, Evelina; Lundberg, Emma; Szigyarto, Cristina Al-Khalili; Skogs, Marie (2014). "Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics". Molecular & Cellular Proteomics: MCP. 13 (2): 397–406. doi:10.1074/mcp.M113.035600. ISSN 1535-9484. PMC 3916642. PMID 24309898.
- ↑ Pineau, Charles; Hikmet, Feria; Zhang, Cheng; Oksvold, Per; Chen, Shuqi; Fagerberg, Linn; Uhlén, Mathias; Lindskog, Cecilia (2019-12-06). "Cell Type-Specific Expression of Testis Elevated Genes Based on Transcriptomics and Antibody-Based Proteomics". Journal of Proteome Research. 18 (12): 4215–4230. doi:10.1021/acs.jproteome.9b00351. ISSN 1535-3893. PMID 31429579.
- ↑ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2024-12-11.
- ↑ "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2024-12-11.
- ↑ Liu, Jinhui (2021). "Development of a novel immune-related lncRNA signature as a prognostic classifier for endometrial carcinoma". International Journal of Biological Sciences. 17 (2): 448–459. doi:10.7150/ijbs.51207. PMC 7893582 Check
|pmc=value (help). PMID 33613104 Check|pmid=value (help). - ↑ Margres, Mark J; Ruiz-Aravena, Manuel; Hamede, Rodrigo; Chawla, Kusum; Patton, Austin H; Lawrance, Matthew F; Fraik, Alexandra K; Stahlke, Amanda R; Davis, Brian W; Ostrander, Elaine A; Jones, Menna E; McCallum, Hamish; Paddison, Patrick J; Hohenlohe, Paul A; Hockenbery, David (2020-08-01). "Spontaneous Tumor Regression in Tasmanian Devils Associated with RASL11A Activation". Genetics. 215 (4): 1143–1152. doi:10.1534/genetics.120.303428. ISSN 1943-2631. PMC 7404226 Check
|pmc=value (help). PMID 32554701 Check|pmid=value (help).
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