Electromics
Electromics, electric field potentiated gene expression, is a subfield of electrobiology, wherein exogenously applied electric fields alter patterns of gene expression within individual cells, cell cultures, tissues, organs and/or whole organisms.
Background[edit]
Electromics, like other omics sub-disciplines, aims at the broad characterization, quantification, and functional validation of pools of biological molecules that translate into the structure, function, and sub-cellular and cellular dynamics of an organism or organisms under the influence of electric fields.[1] The advent of DNA microarrays, RT-qPCR, and RNA sequencing has made it possible to isolate on up- and down-regulated genes influenced by electric fields.
History[edit]
Electric fields in biology have a long and checked past since the 18-century work of Luigi Galvani and Alessandro Volta. Today, controlled exogenous electric fields are associated with chronic wound healing, cancer therapy, electrical stimulation, and electroceutical production. One possible mechanism of action is that such electric fields alter patterns of gene expression among growing and proliferating cells. Endothelial cells express higher levels of VE-cadherins, a major determinant of endothelial cell contact integrity and regulation that support tight junction formation and leakiness of blood vessels.[2] However, electric fields may also produce electroceuticals – nascently produced therapeutic biochemicals enabled by exogenously applied electric fields.
References[edit]
Sara Abasi, Abhishek Jain, John P. Cooke, and Anthony Guiseppi-Elie* “Electrically Stimulated Gene Expression under Exogenously Applied Electric Fields” Front. Mol. Biosci. Sec. Cellular Biochemistry 2023 10.1161191 https://doi.org/10.3389/fmolb.2023.1161191
Ulrich, D., Ulrich, F., Silny, J., Unglaub, F., Pallua, N., “Chiparray-based identification of gene expression in HUVECs treated with low frequency electric fields” Handchir Mikrochir Plast Chir 2006. 38(3), 149–155.https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-2006-924202
Fels, D. The Double-Aspect of Life. Biology 2018, 7, 28. https://doi.org/10.3390/biology7020028
Caputo M, Zirpoli H, De Rosa MC, Rescigno T, Chiadini F, Scaglione A, Stellato C, Giurato G, Weisz A, Tecce MF, Bisceglia B. Effect of low frequency (LF) electric fields on gene expression of a bone human cell line. Electromagn Biol Med. 2014 Dec;33(4):289-95. https://www.tandfonline.com/doi/abs/10.3109/15368378.2013.822387?journalCode=iebm20 Epub 2013 Aug 26. PMID: 23977831.
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- ↑ Caputo M, Zirpoli H, De Rosa MC, Rescigno T, Chiadini F, Scaglione A, Stellato C, Giurato G, Weisz A, Tecce MF, Bisceglia B. Effect of low frequency (LF) electric fields on gene expression of a bone human cell line. Electromagn Biol Med. 2014 Dec;33(4):289-95. https://www.tandfonline.com/doi/abs/10.3109/15368378.2013.822387?journalCode=iebm20. Epub 2013 Aug 26. PMID: 23977831
- ↑ 5. Sara Abasi, John R. Aggas, Naren Venkatesh, Iris Vallavanatt and Anthony Guiseppi-Elie “Design, Fabrication and Testing of an Electrical Cell Stimulation and Recording Apparatus (ECSARA) for Cells in Electroculture" Biosensors and Bioelectronics (2020) 147, 111793 https://doi.org/10.1016/j.bios.2019.111793
