Enzo Nutraceuticals Ltd
| Private | |
| ISIN | 🆔 |
| Industry | Nutraceuticals |
| Founded 📆 | 1998 |
| Founder 👔 | |
Area served 🗺️ | |
| Products 📟 | Enzogenol® pine bark extract; dietary supplements |
| Members | |
Number of employees | |
| 🌐 Website | https://www.enzogenol.com |
| 📇 Address | |
| 📞 telephone | |
Pine bark extract is an extract from the bark of Pinus radiator which can be used as a dietary supplement. It is composed mostly of proanthocyanidins.[1] Enzogenol is a trademarked name for a standardized preparation that contains procyanidins. The National Library of Medicine and Pub Med have several research papers supporting the use of Pink Bark - https://pubmed.ncbi.nlm.nih.gov/18683195/
The effects of Enzogenol on oxidation were published in the following peer-reviewed research articles:
1. Wood, J. E., Senthilmohan, S. T., Peskin, A. V., 2002. Antioxidant activity of procyanidin-containing plant extracts at different phs. Food Chemistry 77, 155-161. https://www.researchgate.net/publication/222664178_Antioxidant_activity_of_procyanidin-containing_plant_extracts_at_different_pH
2. Senthilmohan, S. T., Zhang, J., Stanley, R. A., 2003. Effects of flavonoid extract Enzogenol® with vitamin C on protein oxidation and DNA damage in older human subjects. Nutrition Research 23, 1199-1210.
3. Young, J. M., Shand, B. I., McGregor, P. M., Scott, R. S., Frampton, C. M., 2006. Comparative effects of enzogenol and vitamin c supplementation versus vitamin c alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. Free Radical Research 40(1), 85-94.
https://pubmed.ncbi.nlm.nih.gov/16298763/
Enzo Nutraceuticals Ltd is a New Zealand–based nutraceutical company that uses a propriatory and patented clean water extraction technique to produce and manufacture pine bark as health enhancing anti-imflammatory and anti-oxident ingredient and as finished consumer products. The company is best known for producing Enzogenol®, a pine bark extract derived from Pinus radiata, which is used internationally in dietary supplements and functional food products, skin care, and for non-consumable goods.
History
Jack Masquelier is reported to have read the account of the explorer of Jacques Cartier's learning of the beneficial effects of a tea made from a tree bark by the Native Americans. And on the basis of this account looked to find the active ingredients. Various sources were looked into by Masquelier and he found a suitable source in, and extracted proanthocyanidins from, the bark of the pine.
Enzo Nutraceuticals was founded in 1998 in Paeroa, New Zealand by Barry Giles and Mike Giles. The company was established to develop value-added health ingredients from forestry by-products, with an initial focus on pine bark extraction. Enzo Nutraceuticals Ltd is the exclusive producer and supplier of New Zealand Pinus radiata bark extract brand Enzogenol®.
During the early stages, the company developed a proprietary water-based extraction process and introduced Enzogenol®, a standardized pine bark extract derived from Pinus radiata. Enzogenol was subsequently commercialised internationally and incorporated into nutraceutical products in multiple markets.https://patents.google.com/patent/WO2012057635A1/en
Enzogenol® is a 100% natural extract from the bark of New Zealand grown Pinus radiata trees. Enzogenol® is a stable free flowing powder and has been used extensively for many years to support numerous health applications in dietary supplements, food, beverage, and cosmetic solutions. It is vegan, dairy-free, gluten-free, soy-free, non-GMO, kosher, and halal, and it is safe for children.
Specifically they have focused on helping people with Traumatic Brain Injuries TBI's, Gut health issues, Inflammation and Oxidation and relaxation across their formulations.
In 2013, Enzogenol® received Generally Recognized as Safe (GRAS) status in the United States, permitting its use in food and beverage products.[1]
Products
Enzogenol®
Enzogenol® is a pine bark extract derived from Pinus radiata grown in New Zealand. The extract is produced using a water-only extraction process and contains a range of naturally occurring polyphenolic compounds.
The ingredient is supplied as a bulk nutraceutical ingredient to manufacturers and is also used in finished dietary supplement products marketed by the company.
Consumer supplements
In addition to ingredient supply, Enzo Nutraceuticals markets dietary supplements that incorporate Enzogenol®, formulated for general wellness and cognitive support applications. Enzogenol is used in supplements, topical/cosmetic formats and non-consumable goods
Enzogenol is widely used in **tablets, capsules and liquid supplements** sold under multiple brand names via distributors worldwide, including Arepa and No Ugly.
Skincare and topical products include - Ageless Beauty — uses Enzogenol for "age‑defying antioxidant protection for skin and hair".
- Regional brands supplied via distributors — Enzogenol’s markets/distribution page lists global distributors (USA, India, Japan, Thailand, Philippines, Malaysia, Vietnam)
- Industry listings — Natural Health Products NZ lists Enzogenol in its category and names member companies associated with Enzogenol formulations (examples include Alaron, Biovit, ENZO, HealthPost).
Scientific research
Enzo Nutraceuticals has supported and collaborated on clinical and pre-clinical research investigating the physiological effects and safety of pine bark extracts. Research involving Enzogenol® has been published in peer-reviewed journals.
A double-blind, placebo-controlled trial in middle-aged adults reported improvements in certain cognitive performance measures following supplementation with Enzogenol® over a five-week period.[2]
A randomized, placebo-controlled pilot study in adults with mild traumatic brain injury examined the effects of Enzogenol® on cognitive functioning and reported reductions in self-reported cognitive failures over six weeks of supplementation.[3]
An acute placebo-controlled crossover study in healthy adults investigated glycaemic responses following supplementation with Enzogenol® and reported reductions in post-prandial glucose responses in a subset of participants.[4]
A pilot clinical study examining supplementation with Enzogenol® in combination with vitamin C reported changes in cardiovascular-related markers, including blood pressure and plasma viscosity, over a 12-week period.[5]
Toxicology and safety studies involving human consumption have reported no adverse effects on liver or kidney function at tested doses, supporting regulatory safety assessments.[6]
The effects of Enzogenol on oxidation were published in the following peer-reviewed research articles:
1. Wood, J. E., Senthilmohan, S. T., Peskin, A. V., 2002. Antioxidant activity of procyanidin-containing plant extracts at different phs. Food Chemistry 77, 155-161. https://www.researchgate.net/publication/222664178_Antioxidant_activity_of_procyanidin-containing_plant_extracts_at_different_pH
2. Senthilmohan, S. T., Zhang, J., Stanley, R. A., 2003. Effects of flavonoid extract Enzogenol® with vitamin C on protein oxidation and DNA damage in older human subjects. Nutrition Research 23, 1199-1210.
3. Young, J. M., Shand, B. I., McGregor, P. M., Scott, R. S., Frampton, C. M., 2006. Comparative effects of enzogenol and vitamin c supplementation versus vitamin c alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. Free Radical Research 40(1), 85-94.
https://pubmed.ncbi.nlm.nih.gov/16298763/
The effects of Enzogenol on brain function were published in the following peer-reviewed research articles:
Pipingas, A., Silberstein, R. B., Vitetta, L., Rooy, C. V., Harris, E. V., Young, J. M., Frampton, C. M., Sali, A., Nastasi, J., 2008. Improved cognitive performance after dietary supplementation with a pinus radiata bark extract formulation. Phytotherapy Research 22, 1168-1174. https://pubmed.ncbi.nlm.nih.gov/18683195/
Lim, WXJ et al., 2019. An acute, placebo‐controlled, crossover study to assess the effects of New Zealand pine bark extract on glycaemic responses in healthy participants. Nutrients 2019 Conference: Nutritional Advances in the Prevention and Management of Chronic Disease. https://www.mdpi.com/2072-6643/12/2/497
- These statements have not been evaluated by the Food and Drug Administration, Medsafe, TGA or other authorities. This product is not intended to diagnose, treat, cure or prevent any disease.
Manufacturing and sustainability
The pine bark used in Enzogenol® production is sourced from New Zealand plantation forests and is a by-product of the timber industry. The extraction process uses water rather than organic solvents, and residual biomass is repurposed for agricultural use. It is the only company to do this with Pine Bark.
Regulation
Enzogenol® is permitted for use in dietary supplements in several jurisdictions. In the United States, it holds GRAS status for use in food and beverage products.[7]
See also
- Pine bark extract
- Nutraceutical
- Functional food
References
- ↑ "GRAS Notice for Enzogenol®". U.S. Food and Drug Administration.
- ↑ Pipingas, A.; Silberstein, R. B. (2008). "Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract formulation". Phytotherapy Research. 22 (9): 1168–1174. PMID 18683195.
- ↑ Theadom, A. (2013). "Enzogenol for cognitive functioning in traumatic brain injury: a pilot placebo-controlled RCT". European Journal of Neurology. 20 (8): 1135–1144. PMID 23384428.
- ↑ "An acute, placebo-controlled, single-blind, crossover, dose-response study examining glycaemic responses to Enzogenol®". Nutrients. 12 (2). 2020. PMID 32075228 Check
|pmid=value (help). - ↑ "Pilot study on the clinical effects of dietary supplementation with Enzogenol, a flavonoid extract of pine bark and vitamin C". Phytotherapy Research. 17 (8): 888–894. 2003. PMID 12748985.
- ↑ "Production, composition and toxicology studies of Enzogenol® Pinus radiata bark extract". Sigma-Aldrich.
- ↑ "FDA GRAS Inventory". U.S. Food and Drug Administration. Archived from the original on 2014-03-09. Retrieved 2026-01-14. Unknown parameter
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