Eriomin
Eriomin® is a patented nutraceutical extract of citrus flavonoids mainly comprised of Eriocitrin. Research has expanded the understanding of how Eriomin can impact blood glucose levels, inflammation, oxidative stress, and glucagon-like peptide 1.[1][2][3][4][5]
The pharmacokinetics and biodistribution of Eriocitrin metabolites were tested in vivo. Results found that seven metabolites were widely distributed in various organs, including blood plasma, liver, pancreas, spleen, and kidney[1].
A second in vivo study investigated Eriomin’s impact on periodontal disease. Periodontal inflammation was reduced with the supplementation of the citrus flavonoid by inhibiting gingival IL-1β and TNF-α pro-inflammatory cytokines and increasing IL-10 expression[2].
Eriomin was also assessed in vivo on oxidative stress, inflammation, and glucose and lipid metabolism in high-fat diet-fed obese mice. After eight weeks, the supplemented eriocitrin group had lower levels of glucose and blood and liver triacylglycerols (P < 0.05). Insulin, HOMA-IR, total cholesterol, resistin, and lipid peroxidation levels also improved, demonstrating positive effects on oxidative stress, systemic inflammation, and metabolism of lipids and glucose in general [3].
Two human clinical studies demonstrated how Eriomin, donated by Ingredients by Nature, benefited glycemic control, reduced systemic inflammation and oxidative stress, reversed the prediabetic condition by 24% in evaluated study participants [4], and naturally increased glucagon-like peptide 1 and downregulates systemic inflammation[5].
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- ↑ Ferreira, Paula S.; Manthey, John A.; Nery, Marina S.; Cesar, Thais B. (2021-02-17). "Pharmacokinetics and Biodistribution of Eriocitrin in Rats". Journal of Agricultural and Food Chemistry. 69 (6): 1796–1805. doi:10.1021/acs.jafc.0c04553. ISSN 0021-8561.
- ↑ Carvalho, Jhonatan de Souza; Ramadan, Dania; de Paiva Gonçalves, Vinícius; Maquera-Huacho, Patricia Milagros; Assis, Renata Pires; Lima, Tayra Ferreira Oliveira; Brunetti, Iguatemy Lourenço; Spolidorio, Denise Madalena Palomari; Cesar, Thais; Manthey, John A.; Spolidorio, Luís Carlos (2021). "Impact of citrus flavonoid supplementation on inflammation in lipopolysaccharide-induced periodontal disease in mice". Food & Function. 12 (11): 5007–5017. doi:10.1039/D0FO03338C. ISSN 2042-6496.
- ↑ Ferreira, P. S.; Manthey, J. A.; Nery, M. S.; Spolidorio, L. C.; Cesar, T. B. (2020). "Low doses of eriocitrin attenuate metabolic impairment of glucose and lipids in ongoing obesogenic diet in mice". Journal of Nutritional Science. 9: e59. doi:10.1017/jns.2020.52. ISSN 2048-6790. PMC 7801930 Check
|pmc=value (help). PMID 33489104 Check|pmid=value (help). - ↑ Ribeiro, Carolina B.; Ramos, Fernanda M.; Manthey, John A.; Cesar, Thais B. (July 2019). "Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: A double‐blind, randomized, controlled study". Phytotherapy Research. 33 (7): 1921–1933. doi:10.1002/ptr.6386. ISSN 0951-418X. PMC 6618084 Check
|pmc=value (help). PMID 31183921. - ↑ Cesar, Thais Borges; Ramos, Fernanda Maria Manzini; Ribeiro, Carolina Barbosa (2022-11-01). "Nutraceutical Eriocitrin (Eriomin) Reduces Hyperglycemia by Increasing Glucagon-Like Peptide 1 and Downregulates Systemic Inflammation: A Crossover-Randomized Clinical Trial". Journal of Medicinal Food. 25 (11): 1050–1058. doi:10.1089/jmf.2021.0181. ISSN 1096-620X. PMC 9700344 Check
|pmc=value (help). PMID 35796695 Check|pmid=value (help).
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