Fasting and longevity
Fasting and longevity is a concept of abstaining from food or practicing calorie restriction to reduce the burden of diseases and increase lifespan. [1] Making dietary modifications, such as calorie restriction, dietary restriction, intermittent fasting, and time-restricted feeding, is under research for the potential to influence longevity.[2]
Background[edit]
Although the maintenance of health can be influenced by diet, including the type of foods consumed, the amount of calories ingested, and the duration and frequency of fasting periods,[3] there is no good clinical evidence that fasting can promote longevity in humans, as of 2021.[1]
Caloric restriction is a widely researched intervention to assess effects on aging, defined as a sustained reduction in dietary energy intake compared to the energy required for weight maintenance. To ensure metabolic homeostasis, the diet during calorie restriction must be of high quality, providing sufficient energy, micronutrients, and fiber.[4] According to preliminary research in humans, there is little evidence that calorie restriction affects lifespan.[1][4]
References[edit]
- ↑ 1.0 1.1 1.2 Lee MB, Hill CM, Bitto A, Kaeberlein M (November 2021). "Antiaging diets: Separating fact from fiction". Science. 374 (6570): eabe7365. doi:10.1126/science.abe7365. PMC 8841109 Check
|pmc=value (help). PMID 34793210 Check|pmid=value (help). - ↑ Brandhorst, Sebastian; Longo, Valter D (2019). "Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity". Advances in Nutrition. 10 (Suppl_4): S340–S350. doi:10.1093/advances/nmz079. PMC 6855936 Check
|pmc=value (help). PMID 31728501. - ↑ Longo, Valter D.; Anderson, Rozalyn M. (2022). "Nutrition, longevity and disease: From molecular mechanisms to interventions". Cell. 185 (9): 1455–1470. doi:10.1016/j.cell.2022.04.002.
- ↑ 4.0 4.1 Flanagan, Emily W.; Most, Jasper; Mey, Jacob T.; Redman, Leanne M. (2020-09-23). "Calorie Restriction and Aging in Humans". Annual Review of Nutrition. 40 (1): 105–133. doi:10.1146/annurev-nutr-122319-034601. ISSN 0199-9885. PMC 9042193 Check
|pmc=value (help). PMID 32559388 Check|pmid=value (help).
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