Fei Chen
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| Fei Chen | |
|---|---|
| Born | |
| 🎓 Alma mater | Massachusetts Institute of Technology (PhD) |
| 💼 Occupation | |
| Known for |
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| 🏅 Awards |
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Fei Chen is a bioengineer and biologist known for inventing and co-inventing widely used spatial and single-cell genomics technologies. He co-invented expansion microscopy in 2015,[1] co-developed Slide-seq for high-resolution spatial transcriptomics in 2019,[2] and later co-led methods for in situ genome sequencing[3] and slide-DNA-seq for spatially resolved DNA profiling in tissues.[4] His group’s tools and findings have been covered in independent outlets including Nature technology features and industry reporting.[5][6][7]
Career
Chen is a core institute member at the Broad Institute and an associate professor in Harvard University’s Department of Stem Cell and Regenerative Biology.[8] His laboratory develops technologies that connect single-cell genomics with spatial and temporal context in intact tissues, including Slide-seq and in situ genome sequencing.[8][9] Earlier, Chen co-invented expansion microscopy while a doctoral researcher, enabling optical resolution beyond the diffraction limit by physically expanding specimens.[1]
Independent overviews have situated Slide-seq and Slide-DNA-seq among the major approaches in spatial transcriptomics and spatial genomics.[10][11]
Education
Chen earned a PhD in biological engineering from the Massachusetts Institute of Technology, where he worked with neurotechnology researcher Edward Boyden.[8][12]
Research
Chen’s group builds and applies spatial and single-cell genomics methods to map cell types, states and genetic diversity in healthy and diseased tissues. Applications include developmental biology and tumor evolution, often combining RNA and DNA modalities in the same tissue sections.[4][3][2]
Awards and honors
- NIH Director’s Early Independence Award (2017).[13]
- Searle Scholar (2021).[14]
- Burroughs Wellcome Fund Career Award at the Scientific Interface (CASI).[15]
- NYSCF Robertson Stem Cell Investigator (2023).[16]
- Allen Distinguished Investigator.[17]
Selected publications
- Chen, Fei; Tillberg, Paul W.; Boyden, Edward S. (2015). "Expansion microscopy". Science. 347 (6221): 543–548. Bibcode:2015Sci...347..543C. doi:10.1126/science.1260088. PMC 4322754. PMID 25593119.
- Rodriques, Samuel G.; Stickels, Robert R.; Goeva, Aleksandrina; Martin, Carly A.; Murray, Evan M.; Vanderburg, Charles R.; Welch, Joshua; Chen, Linlin M.; Chen, Fei; Macosko, Evan Z. (2019). "Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution". Science. 363 (6434): 1463–1467. Bibcode:2019Sci...363.1463R. doi:10.1126/science.aaw1219. PMC 6927209 Check
|pmc=value (help). PMID 30923225. - Payne, Andrew C.; Chiang, Zachary D.; Reginato, Paul L.; Mangiameli, Sarah M.; Murray, Evan M.; Yao, Chun-Chen; Markoulaki, Styliani; Earl, Andrew S.; Labade, Ajay S.; Jaenisch, Rudolf; Church, George M.; Boyden, Edward S.; Buenrostro, Jason D.; Chen, Fei (2020). "In situ genome sequencing resolves DNA sequence and structure in intact biological samples". Science. 371 (6532). doi:10.1126/science.aay3446. PMID 33384358 Check
|pmid=value (help). Unknown parameter|article-number=ignored (help) - Zhao, Tongtong; Chiang, Zachary D.; Morriss, Julia W.; LaFave, Lindsay M.; Murray, Evan M.; Del Priore, Isabelle; Meli, Katherine; Lareau, Caleb A.; Nadaf, Naeem M.; Li, Jingyuan; Earl, Andrew S.; Macosko, Evan Z.; Jacks, Tyler; Buenrostro, Jason D.; Chen, Fei (2022). "Spatial genomics enables multi-modal study of clonal heterogeneity in tissues". Nature. 601 (7891): 85–91. Bibcode:2022Natur.601...85Z. doi:10.1038/s41586-021-04217-4. PMC 9301586 Check
|pmc=value (help). PMID 34912115 Check|pmid=value (help).
References
- ↑ 1.0 1.1 Chen, Fei; Tillberg, Paul W.; Boyden, Edward S. (15 January 2015). "Expansion microscopy". Science. 347 (6221): 543–548. Bibcode:2015Sci...347..543C. doi:10.1126/science.1260088. PMC 4322754. PMID 25593119.
- ↑ 2.0 2.1 Rodriques, Samuel G.; Stickels, Robert R.; Goeva, Aleksandrina; Martin, Carly A.; Murray, Evan; Vanderburg, Charles R.; Welch, Joshua; Chen, Linlin M.; Chen, Fei; Macosko, Evan Z. (29 March 2019). "Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution". Science. 363 (6434): 1463–1467. Bibcode:2019Sci...363.1463R. doi:10.1126/science.aaw1219. PMC 6927209 Check
|pmc=value (help). PMID 30923225. - ↑ 3.0 3.1 Payne, Andrew C.; Chiang, Zachary D.; Reginato, Paul L.; Mangiameli, Sarah M.; Murray, Evan M.; Yao, Chun-Chen; Markoulaki, Styliani; Earl, Andrew S.; Labade, Ajay S.; Jaenisch, Rudolf; Church, George M.; Boyden, Edward S.; Buenrostro, Jason D.; Chen, Fei (31 December 2020). "In situ genome sequencing resolves DNA sequence and structure in intact biological samples". Science. 371 (6532). doi:10.1126/science.aay3446. PMC 7962746 Check
|pmc=value (help). PMID 33384358 Check|pmid=value (help). Unknown parameter|article-number=ignored (help) - ↑ 4.0 4.1 Zhao, Tongtong; Chiang, Zachary D.; Morriss, Julia W.; LaFave, Lindsay M.; Murray, Evan M.; Del Priore, Isabelle; Meli, Katherine; Lareau, Caleb A.; Nadaf, Naeem M.; Li, Jingyuan; Earl, Andrew S.; Macosko, Evan Z.; Jacks, Tyler; Buenrostro, Jason D.; Chen, Fei (6 January 2022). "Spatial genomics enables multi-modal study of clonal heterogeneity in tissues". Nature. 601 (7891): 85–91. Bibcode:2022Natur.601...85Z. doi:10.1038/s41586-021-04217-4. PMC 9301586 Check
|pmc=value (help). PMID 34912115 Check|pmid=value (help). - ↑ Callaway, Ewen (15 June 2022). "How to make spatial maps of gene activity — down to the cellular level". Nature. Retrieved 18 October 2025.
- ↑ "'Expansion microscopy' turns ten: how a tissue-swelling method brought super-resolution imaging to the masses". Nature. 13 January 2025. Retrieved 18 October 2025.
- ↑ "Slide-seq hits the spatial biology market as Curio Seeker". GEN. 10 February 2023. Retrieved 18 October 2025.
- ↑ 8.0 8.1 8.2 "Fei Chen". Broad Institute. 5 October 2017. Retrieved 18 October 2025.
- ↑ "Fei Chen, PhD". Harvard Stem Cell Institute. Retrieved 18 October 2025.
- ↑ "Three views are better than one" (PDF). Nature Methods. 2022. Retrieved 18 October 2025.
- ↑ Bishop, Donna (20 March 2019). "Companies seek slice of spatial imaging market". Nature. Retrieved 18 October 2025.
- ↑ "Expansion Microscopy — MIT Media Lab". Retrieved 18 October 2025.
- ↑ "Ten researchers from MIT and Broad receive NIH Director's Awards". MIT News. 5 October 2017. Retrieved 18 October 2025.
- ↑ "Fei Chen – Searle Scholars Program". Searle Scholars. 20 December 2021. Retrieved 18 October 2025.
- ↑ "Grant Recipients — Career Awards at the Scientific Interface". Burroughs Wellcome Fund. Retrieved 18 October 2025.
- ↑ "Fei Chen, PhD — NYSCF". New York Stem Cell Foundation. 23 October 2023. Retrieved 18 October 2025.
- ↑ "Fei Chen, Ph.D. — HSCRB". Harvard University. Retrieved 18 October 2025.
External links
- Official website
- Harvard profile: "Fei Chen, PhD". Harvard Stem Cell Institute. Retrieved 18 October 2025.
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