Frank Arguello
| Frank Arguello | |
|---|---|
 Frank_Arguello.jpg | |
| Born | Francisco Arguello Astorga Mexico |
| 🎓 Alma mater | University of Nuevo Leon School of Medicine |
| 💼 Occupation | |
Frank Arguello is an American cancer research scientist, Medical Doctor and author. He introduced the concepts of “atavistic oncology” and “atavistic chemotherapy.” He is the creator and director of the Atavistic Chemotherapy Clinical Trial.
Biography[edit]
Arguello graduated from College of Bachelors in Torreon, Mexico, in 1978, with a degree in biology. He earned his earned his M.D. from University of Nuevo León School of Medicine in Monterrey, Mexico in 1984 and completed a fellowship at The James P. Wilmont Cancer Centre in Rochester, New York. He is a former assistant professor of pediatrics, Division of Hematology and Oncology at the University of Rochester School of Medicine and Dentistry, and assistant professor of oncology at Strong Memorial Hospital Cancer Center in Rochester, New York.
Arguello is also a former scientist with the National Cancer Institute, Division of Cancer Treatment & Diagnosis, at the National Institutes of Health (NIH) in Maryland conducting pre-clinical trials and evaluating the potential anticancer properties of new drugs being discovered at the NCI's screening programs. In 2011, he published a book Atavistic Metamorphosis: A New and Logical Explanation for the Origin and Biological Nature of Cancer which gave genesis to the Atavistic Chemotherapy Clinical Trial.
Research[edit]
Arguello's early research was focused on understanding cancer metastases. His investigations led to the development of laboratory animal models to develop and study experimental metastases to the bones and other organs. Using this model, he studied and described the sequence of events that take place during bone metastasis, particularly vertebral metastasis and spinal cord compression. Arguello and colleagues at the University of Rochester also established that both vascular access of cancer cells to a target organ and the tissue microenvironment in it played a critical role in the establishment of metastases.
At the NIH, NCI, Arguello evaluated several novel anticancer agents including 9-chloro-2-methylellipticinium acetate, alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts, and flavopiridol in the treatment of xenografted human leukemias and lymphomas.
Arguello's current research includes investigations of the unique and perplexing traits shared by pathogenic unicellular organisms and cancer cells.
Selected publications[edit]
- A murine model of experimental metastasis to bone and bone marrow, F Arguello, RB Baggs, CN Frantz, Cancer research 48 (23), 6876-6881 408, 1988
- Flavopiridol induces apoptosis of normal lymphoid cells, causes immunosuppression, and has potent antitumor activity in vivo against human leukemia and lymphoma xenografts, F Arguello, Mark Alexander, Judith A Sterry, Gabriela Tudor, Erik M Smith, Naina T Kalavar, John F Greene Jr, William Koss, C David Morgan, Sherman F Stinson, Timothy J Siford, W, Gregory Alvord, Richard L Klabansky, Edward A Sausville, Blood, The Journal of the American Society of Hematology 91 (7), 2482-2490,302, 1998
- Pathogenesis of vertebral metastasis and epidural spinal cord compression, F Arguello, RE Duerst, K McQueen, CN Frantz, RB Baggs, L Johnstone, Cancer 65 (1), 98-106, 208, 1990
- Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv), Richard W Furlanetto, Raymond B Baggs, Brian T Graves, Shari E Harwell, Harvey J Cohen, Christopher N Frantz, Cancer research 52 (8), 2304-2309, 59, 1992
- Vascular anatomy and organ‐specific tumor growth as critical factors in the development of metastases and their distribution among organs, F Arguello, RB Baggs, AE Eskenazi, RE Duerst, CN Frantz, International journal of cancer 48 (4), 583-590, 34 ,1991
- Preclinical evaluation of 9-chloro-2-methylellipticinium acetate alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts, F Arguello, MA Alexander, JF Greene Jr, SF Stinson, JL Jorden, EM Smith, Journal of cancer research and clinical oncology 124 (1), 19-26, 22, 1998
- Experimental bone and bone marrow metastasis in laboratory animals, F ARGUELLO, CN FRANTZ, RB BAGGS, JNCI: Journal of the National Cancer Institute 82 (12), 1069-1070, 4, 1990
References[edit]
External links[edit]
- Frank Arguello publications indexed by Google Scholar
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