Halyna R. Shcherbata
| Halyna R. Shcherbata | |
|---|---|
 Halyna R. Shcherbata | |
| Born | Lviv, Ukraine |
| 🏳️ Nationality | Ukrainian-German |
| 🎓 Alma mater | Lviv National University |
| 💼 Occupation | |
| Known for | RNA biology, Disease modeling, Gene regulation |
| 🏅 Awards | EMBO Young Investigator Award (2014), American Heart Association Award (2005) |
| 🌐 Website | Shcherbata Lab |
Halyna Shcherbata is a Ukrainian-German scientist specializing in molecular and developmental biology, with a focus on RNA biology, cell signaling, and disease modeling. She is a Professor of Cellular Signal Transduction in Biochemistry at Hannover Medical School (MHH) and an Honorary Professor at the University of Göttingen. Previously, she was a Max Planck Research Group Leader at the Max Planck Institute for Biophysical Chemistry, which is now part of the Max Planck Institute for Multidisciplinary Sciences (MPG-MPINAT) in Göttingen, Germany.
Education and Career
Education and Career
Shcherbata earned her M.Sc. in Biology and Chemistry from University of Lviv, Ukraine, and later completed her Ph.D. in Genetics at the Department of Genetics and Biotechnology, University of Lviv[1].
She then conducted postdoctoral research at:
- Basel University, Switzerland – Neurobiology
- University of Washington, Seattle, USA – Stem Cell Biology & Biochemistry
In 2007, she became a Research Professor (Acting Instructor) at the Institute for Stem Cell and Regenerative Medicine, University of Washington. From 2008 to 2018, she was a Max Planck Research Group Leader at MPG-MPINAT, Göttingen, Germany [2]. In 2018, she joined Hannover Medical School (MHH) as a Professor of Cellular Signal Transduction in Biochemistry [3] and in 2024, MDI Biological Laboratory (MDIBL) as a Principal Investigator [4] .
Shcherbata is also an EMBO Young Investigator and has received international recognition for her contributions to RNA biology and gene regulation [5], [6].
Research Contributions
Shcherbata’s research is focused on microRNA (miRNA) regulation, RNA-binding proteins (RBPs), and cellular responses to stress and disease, primarily using Drosophila melanogaster as a model system. Her work has contributed to understanding muscular dystrophies, neurodegenerative disorders, and post-transcriptional and translational regulation under stress conditions.
Key Discoveries and Projects
- MicroRNA Regulation in Stem Cells: As a first co-author on a seminal Nature paper [7], Shcherbata was among the first to demonstrate that miRNAs regulate stem cell division and cellular homeostasis [8], [9], [10], [11], [12], [13].
- Disease Modeling Using Drosophila : Her lab developed models for muscular dystrophy and lissencephaly type II, leading to insights into the Dystrophin Glycoprotein Complex (DGC) and its interactions with the Hippo signaling pathway [14], [15], [16].
- Stress Responses and RNA-Binding Proteins: Her research on Rbfox1 [17] and translational readthrough [18] has revealed new mechanisms by which RNA-protein interactions regulate cell survival under stress conditions.
- Exome Sequencing Initiative in Ukraine: She led the implementation of next-generation sequencing (NGS) diagnostics for newborns in Ukraine [19], which is now government-funded and provided free of charge for children in need.
Funding and Grants
Shcherbata has received funding from prestigious international agencies, including:
- Deutsche Forschungsgemeinschaft (DFG)
- Volkswagen Stiftung
- European Molecular Biology Organization (EMBO)
- Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ)
- American Heart Association (AHA)
She played a crucial role in strengthening genetic diagnostics in Ukraine, particularly through the GIZ Klinikpartnerschaften grant, which facilitated the training of Ukrainian researchers in exome sequencing and genetic diagnostics [20].
Mentorship and Teaching
Shcherbata has supervised Ph.D., M.Sc., and B.Sc. students from various countries. She serves on the Executive Board of the Hannover Biomedical Research School (HBRS) and contributes to graduate programs in Molecular Medicine and Regenerative Sciences at Hannover Medical School [21].
Selected Publications
- Tsap M. I., Yatsenko A. S., Hegermann J., Beckmann B., Tsikas D., Shcherbata H. R. (2024). Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolism. *eLife*.
- Karki P., Carney T. C., Maracci C., Yatsenko A. S., Shcherbata H. R., Rodnina M. V. (2022). Tissue-specific regulation of translational readthrough tunes functions of the traffic jam transcription factor. *Nucleic Acids Research*.
- Yatsenko, A. S., Kucherenko M. M., Xie Y., Urlaub H., Shcherbata H. R. (2021). Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor Dystroglycan is required for proper brain compartmentalization. *eLife*.
- Yatsenko AS, Kucherenko MM, Xie Y, Aweida D, Urlaub H, Scheibe RJ, Cohen S, Shcherbata HR. (2020). Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. *BMC Medicine*.
- Kucherenko M., Shcherbata H. R. (2018). Stress-dependent miR-980 regulation of Rbfox1/A2bp1 promotes ribonucleoprotein granule formation and cell survival. *Nature Communications*.
- Yatsenko A., Shcherbata H.R. (2018). Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling. *Development*.
- Çiçek, IO, Karaca, S, Brankatschk, M, Eaton, S, Urlaub, H, Shcherbata, H.R. (2016). The mir-310s target Hh signaling to rebalance the metabolic status and sustain healthy homeostasis upon dietary changes. *Genetics*.
- Yatsenko, A. S., Shcherbata, H. R. (2014). Drosophila miR-9a targets the ECM receptor Dystroglycan to canalize myotendinous junction formation. *Developmental Cell*.
- Fagegaltier, D., Konig, A., Gordon, A., Lai, E. C., Gingeras, T. R., Hannon, G. J., Shcherbata, H. R. (2014). A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs Identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity. *Genetics*.
- Yatsenko, A. S., Marrone, A. K., Shcherbata, H. R. (2014). miRNA-based buffering of the cobblestone-lissencephaly-associated extracellular matrix receptor dystroglycan via its alternative 3'-UTR. *Nature Communications*.
- Kucherenko M.M., Barth J., Fiala A., Shcherbata H.R. (2012). Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain. *EMBO Journal*.
- Konig, A., Yatsenko, A.S., Weiss, M., Shcherbata, H.R. (2011). Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation. *EMBO Journal*.
- Shcherbata, H.R., Yatsenko, A.S., Patterson, L., Sood, V.D., Nudel, U., Yaffe, D., Baker, D., Ruohola-Baker, H. (2007). Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy. *EMBO Journal*.
- Shcherbata, H.R., Ward, E.J., Fischer, K.A., Yu, J.Y., Reynolds, S.H., Chen, C.H., Xu, P., Hay, B.A., Ruohola-Baker, H. (2007). Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary. *Cell Stem Cell*.
- Shcherbata, H.R., Althauser, C., Findley, S.D., Ruohola-Baker, H. (2004). The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M, and M/G1 cell-cycle transitions. *Development*.
- Hatfield, S.D., Shcherbata, H.R., Fischer, K.A., Nakahara, K., Carthew, R.W., Ruohola-Baker, H. (2005). Stem cell division is regulated by the microRNA pathway. *Nature*.
- Tsap M. I., Yatsenko A. S., Hegermann J., Beckmann B., Tsikas D., Shcherbata H. R. (2024). Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, and abnormal fatty acid metabolism. *eLife*.
- Karki P., Carney T. C., Maracci C., Yatsenko A. S., Shcherbata H. R., Rodnina M. V. (2022). Tissue-specific regulation of translational readthrough tunes functions of the traffic jam transcription factor. *Nucleic Acids Research*.
- Yatsenko, A. S., Kucherenko M. M., Xie Y., Urlaub H., Shcherbata H. R. (2021). Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor Dystroglycan is required for proper brain compartmentalization. *eLife*.
Awards and Recognition
- EMBO Young Investigator Award (2014)
- American Heart Association (AHA) Award for Postdoctoral Fellows (2005)
- West-Ukrainian Biomedical Research Award (2002)
- George Soros Award for Young Scientists (2000)
Professional Memberships
- Gesellschaft für Biochemie und Molekularbiologie (GBM)
- Gesellschaft für Entwicklungsbiologie (GfE)
- Genetics Society of America (GSA)
- Deutsch-Ukrainische Akademische Gesellschaft (DUAG)
Editorial and Review Work
Shcherbata serves as an expert reviewer for major funding agencies, including:
- European Research Council (ERC)
- Deutsche Forschungsgemeinschaft (DFG)
- Alexander von Humboldt Foundation
- Medical Research Council (UK)
- Inserm Atip-Avenir Programme (France)
- AFM-Téléthon (France)
- Foundation of Science and Technology (Portugal)
- The Wellcome Trust DBT India Alliance Fellowships (UK)
- Hellenic Foundation for Research and Innovation (Greece)
- US National Fellowship Committee for Graduate Women in Science
External Links
References
This article "Halyna Shcherbata Wiki" is from Wikipedia. The list of its authors can be seen in its historical and/or the page Edithistory:Halyna Shcherbata Wiki. Articles copied from Draft Namespace on Wikipedia could be seen on the Draft Namespace of Wikipedia and not main one.
- ↑ https://www.uni-goettingen.de/de/105883.html
- ↑ https://www.mpg.de/7311236/Jahresbericht_2008_Nachwuchsfoerderung.pdf
- ↑ https://www.mpinat.mpg.de/621478/10_MPIbpcNews_Oktober_2018.pdf
- ↑ https://mdibl.org/tag/halyna-shcherbata/
- ↑ https://www.mpinat.mpg.de/652069/pr_1436
- ↑ https://yip-search.embo.org/#/yip/2638
- ↑ https://www.nature.com/articles/nature03816
- ↑ https://www.tandfonline.com/doi/10.4161/cc.5.2.2343?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
- ↑ https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(07)00280-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590907002809%3Fshowall%3Dtrue
- ↑ https://www.tandfonline.com/doi/10.4161/cc.8.22.10033?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
- ↑ https://www.embopress.org/doi/full/10.1038/emboj.2012.298
- ↑ https://www.cell.com/developmental-cell/fulltext/S1534-5807(14)00027-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1534580714000276%3Fshowall%3Dtrue
- ↑ https://academic.oup.com/genetics/article/198/2/647/5935931?login=false
- ↑ https://www.embopress.org/doi/full/10.1038/sj.emboj.7601503
- ↑ https://www.nature.com/articles/ncomms5906
- ↑ https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-019-1478-3
- ↑ https://www.nature.com/articles/s41467-017-02757-w
- ↑ https://academic.oup.com/nar/article/50/11/6001/6456227?login=false
- ↑ https://hospitalpartnerships.org/projects/stärkung-der-genetischen-diagnostik-durch-einführung-der-exom-sequenzierung-in-die-klinische-praxis
- ↑ https://hospitalpartnerships.org/projects/stärkung-der-genetischen-diagnostik-durch-einführung-der-exom-sequenzierung-in-die-klinische-praxis
- ↑ https://www.mhh.de/hbrs/mdphd/coordination-and-contact
