Hexadecyl
Hexadecyl is a functional group chain molecule of carbon and hydrogen, with formula C16H33 and with average mass 225.433.[1] It is "an alkyl radical derived from a hexadecane," especially a cetyl.[2] It is on the Enzyme Commission number list. It is a noted hydrophobe.[3]
The substance synthesized by Hexadecyl, Carboplatin and polyethylene glycol appears to have increased liposolubility and PEGylation qualities. This may be useful in chemotherapy, specifically non-small cell lung cancer.[4]
Hexadecyl was noted as early as 1982 for its role in radiolabelling.[5] The technique of which it forms a vital part has continued to be useful even as late as 2017.[6] In fact, it is useful to radiolabel exosomes and hydrogels.[7]
Hexadecyl is a bridge molecule important for positron emission tomography.[8]
Hexadecyl platelet-activating factor "has profound effects on the lung".[9]
Hexadecyl and octadecyl groups are favoured by some in the production of Lysophosphatidic acid.[10]
Hexadecyl glyceryl ether is important in the biosynthesis of plasmalogens.[11]
Related articles[edit]
- Cetyl palmitate
- Cetyl alcohol
- Spermaceti
- Palmitic acid
- Isoceteth-20
- Cetrimide
- Cetomacrogol 1000
- Langmuir–Blodgett film
References[edit]
- ↑ "Hexadecyl". Royal Society of Chemistry. ChemSpider. Retrieved 3 April 2021.
- ↑ "hexadecyl noun". Merriam-Webster.
- ↑ Hatanaka, K (2011). Horváth, István T., ed. Fluorous Chemistry. Springer Science & Business Media. p. 294. Search this book on
- ↑ Lang, Tingting; Li, Nuannuan; Zhang, Jing; Li, Yi; Rong, Rong; Fu, Yuanlei (2021). "Prodrug-based nano-delivery strategy to improve the antitumor ability of carboplatin in vivo and in vitro". Drug Delivery. 28 (1): 1272–1280. doi:10.1080/10717544.2021.1938754. PMC 8238065 Check
|pmc=value (help). PMID 34176381 Check|pmid=value (help). - ↑ Pool, G. L.; French, M. E.; Edwards, R. A.; Huang, L.; Lumb, R. H. (1982). "Use of radiolabeled hexadecyl cholesteryl ether as a liposome marker". Lipids. 17 (6): 448–452. doi:10.1007/BF02535225. PMID 7050582. Unknown parameter
|s2cid=ignored (help) - ↑ Manual Kollareth, Denny Joseph; Chang, Chuchun L.; Hansen, Inge H.; Deckelbaum, Richard J. (2018). "Radiolabeled cholesteryl ethers: A need to analyze for biological stability before use". Biochemistry and Biophysics Reports. 13: 1–6. doi:10.1016/j.bbrep.2017.10.007. PMC 5697731. PMID 29188234.
- ↑ Lee, Yanick (July 2017). Radiosynthesis of hexadecyl-4-[ 18F]fluorobenzoate for labeling exosomes and chitosan hydrogels (Master's thesis). Université de Montréal. Search this book on
- ↑ "Radioactive cell labeling agent". KR101130737B1. 2012.
- ↑ Haroldsen, P. E.; Voelkel, N. F.; Henson, J. E.; Henson, P. M.; Murphy, R. C. (1987). "Metabolism of platelet-activating factor in isolated perfused rat lung". Journal of Clinical Investigation. 79 (6): 1860–1867. doi:10.1172/JCI113028. PMC 424530. PMID 3108322.
- ↑ "USPTO 20060264361".
- ↑ Wood, Randall; Healy, Kathleen (1970). "Tumor lipids: Biosynthesis of plasmalogens". Biochemical and Biophysical Research Communications. 38 (2): 205–211. doi:10.1016/0006-291x(70)90697-2. PMID 5418699.
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