Homeostatic Medicine
Homeostatic Medicine is a comprehensive discipline that encompasses the study of homeostasis within human molecules, cells, organs, and the entire body. It emphasizes the crucial role of maintaining homeostatic balance in promoting human health and facilitating the prevention and diagnosis of diseases. By focusing on the interplay between homeostasis and health, as well as disease, homeostatic medicine offers novel insights and strategies for the maintenance of well-being and the management of various health conditions.[1][2]
"Homeostatic Medicine" is a medical concept proposed by Academician Songlin Wang (王松灵) from the Chinese Academy of Sciences. [1]
Overview
Homeostatic Medicine is an important domain within physiology. The concept of "Yin and Yang" in Traditional Chinese Medicine and the "Humorism" in Ancient Greek medicine both reflect early understandings of homeostatic medicine. In 1865, the French physiologist Claude Bernard proposed the theory of "Internal environment" (milieu intérieur)[3] to describe the interstitial fluid and its physiological capacity to ensure protective stability for the tissues and organs of multicellular organisms. The word 'homeostasis' was then coined by Walter Bradford Cannon in 1926 to extend Bernard's milieu intérieur concept[4]. Further advancements in the theory of human body related homeostasis were proposed by Chinese scientist Qian Xuesen, who introduced the theories of "Somatic Eigenstate" and "Metastability"[5]. The exploration and comprehension of the relationship between health and disease, through the study of the establishment, disruption, and maintenance of homeostasis in the human body, is progressively emerging as a significant branch in contemporary medicine.
The essence of health lies in the ability to maintain homeostasis. From the perspective of Homeostatic Medicine, disease can be defined as a deficiency in the capacity to maintain stable internal conditions, leading to a decreased ability of the organism and its systems to adapt to external stressors, ultimately resulting in the manifestation of illness. Therefore, maintaining organism health at its core involves improving the body's ability to maintain homeostasis. Research related to homeostatic Medicine comprises various aspects, such as evolution and adaptation, regulation of environmental adaptation capabilities, excitatory effects of toxic substances, preadaptation, and the milieu interne indicators such as blood pressure, blood glucose, blood lipids, bioenergetics, thermoregulation, nervous system, immune function, endocrine system, and acid-base balance.
The research in homeostatic Medicine encompasses three aspects:
- Gaining an in-depth understanding of the mechanisms involved in homeostatic regulation and their role in maintaining overall health;
- Analyzing the factors and triggers that disrupt homeostasis during the disease process;
- Integrating the knowledge gathered from the previous two steps to implement appropriate interventions that restore the body's homeostatic equilibrium, thereby promoting health maintenance and disease prevention.
Given the pivotal role of homeostasis in both health and disease, homeostatic medicine holds vast potential for application across a wide range of medical conditions.[6]
References
- ↑ Wang, Songlin; Qin, Lizheng (2022). "Homeostatic medicine: a strategy for exploring health and disease". Current Medicine (Cham, Switzerland). 1 (1): 16. doi:10.1007/s44194-022-00016-9. ISSN 2731-0868. PMC 9510546 Check
|pmc=value (help). PMID 36189427 Check|pmid=value (help). - ↑ Zhou, Jian; Liu, Huan; Hu, Lei; Kagami, Hideaki; Wang, Songlin (2024-03-01). "Nitrate and body homeostasis". Medicine Plus. 1 (1): 100003. doi:10.1016/j.medp.2023.100003. ISSN 2950-3477.
- ↑ Noble, Denis (2008). "Claude Bernard, the first systems biologist, and the future of physiology". Experimental Physiology. 93 (1): 16–26. doi:10.1113/expphysiol.2007.038695. ISSN 0958-0670. PMID 17951329. Unknown parameter
|s2cid=ignored (help) - ↑ Cannon, Walter B. (1929-07-01). "Organization for Physiological Homeostasis". Physiological Reviews. 9 (3): 399–431. doi:10.1152/physrev.1929.9.3.399. ISSN 0031-9333.
- ↑ Qian, Xuesen. "Some Knowledge of Study of Somatic Science" (PDF). Chinese Journal of Somatic Science. 1 (2): 52–57 – via Central Intelligence Agency.
- ↑ Qin, L. Z.; Zhou, J.; Hu, L.; Wang, S. L. (2023-02-09). "[Homeostatic medicine: new strategy and concept of health maintenance as well as diagnosis and treatment of diseases]". Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology. 58 (2): 109–117. doi:10.3760/cma.j.cn112144-20221206-00607. ISSN 1002-0098. PMID 36746443 Check
|pmid=value (help).
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