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Hugh S. Taylor

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Hugh S. Taylor
Born
Known forObstetrics, gynecology, and reproductive sciences

Hugh S. Taylor is a clinician, educator, and researcher in the field of obstetrics, gynecology and reproductive sciences. He is Chair of the Department of Obstetrics Gynecology and Reproductive Sciences at Yale School of Medicine and Chief of Obstetrics and Gynecology at Yale-New Haven Hospital. His clinical interests include In vitro fertilisation, infertility, endometriosis, implantation, menopause, uterine anomalies and DES exposure.[1]

Education and career[edit | edit source]

Hugh Taylor received his undergraduate degree in Molecular Biophysics and Biochemistry from Yale University in 1983 and his medical degree from University of Connecticut in 1983. He completed his residency in Obstetrics and Gynecology at Yale-New Haven Hospital and fellowships in Reproductive Endocrinology and Infertility, and Molecular Bio, at Yale University School of Medicine.[2][1]

In addition to his clinical practice, Taylor holds multiple positions at Yale. He is the Anita O'Keeffe Young Professor of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine and a Professor of Molecular, Cellular and Developmental Biology at Yale University.[2] Taylor served as Chief of Reproductive Endocrinology and Infertility before being named Chair of the Department of Obstetrics, Gynecology, and Reproductive Sciences at Yale School of Medicine and Chief of Obstetrics and Gynecology at Yale–New Haven Hospital in 2012.[3]

Outside of the Yale School of Medicine, Taylor holds other leadership roles. Taylor "is the editor-in-chief of the journal Reproductive Sciences and editor of Endocrinology. He serves on the board of directors of the American Society for Reproductive Medicine (ASRM), where he is president-elect of the endometriosis interest group and on the governing council of the Society for Gynecologic Investigation (SGI)."[4] Taylor is also Clinical Director of the Society for Assisted Reproductive Technology, the organization that sets standards for in vitro fertilization practice in the United States[3] and a clinical adviser to the Endometriosis Association.[5]

Research[edit | edit source]

Taylor's research has been continuously funded by the National Institutes of Health (NIH) for more than 20 years. He has received eight NIH grants for his research and has published over 125 articles in prominent medical journals.[6]Taylor's clinical research focuses on endometriosis, implantation, and menopause.[7]

Endometriosis[edit | edit source]

Taylor's research group has identified mechanisms and molecules that lead to and regulate endometriosis, including stem cells, epigenetics and microRNAs.[7] In 2016 and 2017, Taylor contributed to studies that found significant levels of multiple microRNA biomarkers in patients with surgically confirmed endometriosis.[8] Additionally, his laboratory was the first to identify an outside source of stem cells that contribute to endometrial regeneration.[9]

Taylor presented his group's papers on serum microRNAs for diagnosing endometriosis and increased anxiety, depression, and pain perception with endometriosis in mice at the 2017 American Society for Reproductive Medicine conference. His research was awarded with the Endometriosis Special Interest Group (EndoSIG) clinical/population science prize paper[10]and EndoSIG basic science prize paper.[10]

Implantation[edit | edit source]

In the late 1990s, Taylor and his colleagues published a series of studies showing the function of a homeotic gene called HOXA10, which is expressed during implantation in the endometrium.[11] They found that this gene is altered in the endometrium of women with endometriosis and in infertility cases associated with failed implantation.[12]

Menopause[edit | edit source]

Clinical and translational studies performed by Taylor's research team look at the effects of endometrial menopausal hormone therapies.[13] These studies show that hormone therapies for menopause may lead to increased risk of breast cancer in some patients[14] and emphasize the benefit of using individualized care methods when treating menopause.[15]

Awards and honors[edit | edit source]

  • National Academy of Medicine 2016[7]
  • EndoSIG clinical/population science prize paper[10]
  • EndoSIG basic science prize paper[10]
  • President's Achievement Award and President's Presenter Award from Society for Gynecologic Investigation 2008[16]
  • Mentor of the Year by the American College of Obstetricians and Gynecologists[16]
  • Honoree of the Year by the Endometriosis Foundation of America[16]
  • Physician's Scientist Award by National Institutes of Health[6]
  • Top Doctors List by Connecticut magazine[2]
  • Best clinical research record in reproduction medicine award by International Fundacion IVI[17]

References[edit | edit source]

  1. 1.0 1.1 "Yale Medicine-People". Yale School of Medicine.
  2. 2.0 2.1 2.2 "Yale Medicine Doctors". yalemedicine.org.
  3. 3.0 3.1 "People and Organizations at YSM". Yale School of Medicine.
  4. "Hugh S. Taylor, MD, named chief of OB/GYN". Yale New Haven Hospital.
  5. "Endometriosis Association Advisors". Endometriosis Association Online.
  6. 6.0 6.1 "Hugh S. Taylor". Sage Publishing.
  7. 7.0 7.1 7.2 "OB/GYN's Hugh Taylor elected to National Academy of Medicine". Yale School of Medicine.
  8. "Serum micrornas used to diagnose endometriosis prior to surgical diagnosis: a prospective study". Fertility and Sterility. 108 (3).
  9. "Endometriosis and Stem Cell Trafficking". Reproductive Sciences. 23 (12). October 6, 2016.
  10. 10.0 10.1 10.2 10.3 "ASRM2017". endometriosis.org.
  11. "HOXA10 expression in ectopic endometrial tissue". Fertility and Sterility. 85 (5): 1386–1390. May 2006.
  12. "MicroRNA 135 Regulates HOXA10 Expression in Endometriosis". The Journal of Clinical Endocrinology and Metabolism. December 2011.
  13. "Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women". PLOS Medicine. June 2015.
  14. "The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk". Endocrinology and metabolism clinics of North America. 2015.
  15. "Precision menopausal medicine". Menopause. 24 (5). May 2017.
  16. 16.0 16.1 16.2 "Hugh S. Taylor". New Haven Health.
  17. "Awards". Foundation IVI.



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