Humsa Venkatesh
| Humsa Venkatesh | |
|---|---|
 Humsa Venkatesh Photo.png | |
| Born | |
| 🎓 Alma mater | University of California, Berkeley Stanford University |
| 💼 Occupation | |
Humsa Venkatesh is a cancer neuroscientist developing new approaches to cancer therapeutics that target the nervous system's central role in facilitating tumor growth.[1][not in citation given][2] Her research identifies novel relationships between biological systems and cancer growth to pioneer new treatment strategies.[3][2] She is an Assistant Professor at the Brigham and Women’s Hospital and the Harvard Medical School Department of Neurology.[4]
Education & early career
Venkatesh graduated from the University of California, Berkeley College of Chemistry where she majored in Chemical Biology and researched ribosomal mRNA recruitment with Jennifer Doudna. She subsequently worked at the University of California, San Francisco with Sabrina Ronen where she studied altered metabolism through the PI3K pathway in various cancers using novel hyperpolarized spectroscopy techniques.
Venkatesh completed her graduate and postdoctoral training at the Stanford University School of Medicine with Michelle Monje and Robert Malenka. She then served as an Instructor in the Department of Neurology at the Stanford University School of Medicine until 2021.[5]
Research
The Venkatesh Lab's interdisciplinary research combines neuroscience, cancer biology and the tumor microenvironment to study how normal mechanisms of plasticity and development, focusing on neuronal activity, are hijacked by cancers.[6] Venkatesh investigates the impacts of systems-level microenvironmental effects on malignant growth.[3][7][8]
Venkatesh's graduate and postdoctoral research work unveiled the relationship between neuronal activity and glioma growth[9] and further identified a secreted microenvironmental therapeutic target which, when inhibited, stagnates glioma growth *in vivo*. [10] This work led to clinical trials approved to treat glioma. More recently, Venkatesh illustrated that malignant glioma networks are electrically active and functionally integrate into neural circuitry through synapses.[11]
At Harvard Medical School, the Venkatesh Lab uses novel systems neuroscience tools applied to various cancer models to understand how the activity of the nervous system affects tumor growth. Venkatesh has identified processes through which reciprocal electrical communication between neurons and malignant cancer cells drive tumor progression both in and outside of the brain, with current projects focused on small cell lung cancer.[12] [13]
Selected awards
- MIT Technology Review TR35 Pioneer (2018)[14]
- AAAS Science & SciLife Prize for Young Scientists (2019)[1] [15]
- Genetic Engineering & Biotechnology News Top 10 Under 40 (2019)[16]
- Sontag Foundation Distinguished Scientist (2022)[17]
References
- ↑ 1.0 1.1 Venkatesh, Humsa (November 22, 2019). "The Neural Regulation of Cancer". Science. 366 (6468): 965. Bibcode:2019Sci...366..965V. doi:10.1126/science.aaz7776. PMID 31753994. Retrieved 24 January 2023. Unknown parameter
|s2cid=ignored (help) - ↑ 2.0 2.1 Bender, Maddie (August 15, 2022). "Humsa Venkatesh Probes Cancer's Grip on the Brain" (2). The Scientist. Retrieved 24 January 2023.
- ↑ 3.0 3.1 "Research initiative studies prevention of neurodegenerative diseases". The Daily Californian. 2022-07-18. Retrieved 2023-10-02.
- ↑ "Humsa Venkatesh". pinphd.hms.harvard.edu. Retrieved 2023-10-02.
- ↑ "Humsa Venkatesh - Society for NeuroOncology". Retrieved 27 January 2023.
- ↑ CCR Grand Rounds - 2023 AAAS Martin and Rose Wachtel Cancer Research Award and Lecture: Harnessing Microenvironmental Dependencies for Cancer Therapy – The Role of the Nervous System in Cancer Growth, 2023-07-28, retrieved 2023-10-02
- ↑ [email protected], <img src='https://med stanford edu/news/media-contacts/erin_digitale/_jcr_content/image img 620 high jpg/digitale-erin-90 jpg' alt='Erin Digitale'> Erin Digitale Erin Digitale is a senior science writer in the Office of Communications Email her at (2014-04-10). "Brain tumor growth stimulated by nerve activity in the cortex, study finds". News Center (in Gagana Samoa). Retrieved 2023-10-02.
- ↑ Cariz, Joseph. "Scientist Receives Prize for Discoveries about Neuron-Cancer Connections". AAAS News. Retrieved 2023-10-02.
- ↑ Venkatesh, Humsa S.; Johung, Tessa B.; Caretti, Viola; Noll, Alyssa; Tang, Yujie; Nagaraja, Surya; Gibson, Erin M.; Mount, Christopher W.; Polepalli, Jai; Mitra, Siddhartha S.; Woo, Pamelyn J.; Malenka, Robert C.; Vogel, Hannes; Bredel, Markus; Mallick, Parag; Monje, Michelle (May 7, 2015). "Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion". Cell. 161 (4): 803–816. doi:10.1016/j.cell.2015.04.012. PMC 4447122. PMID 25913192. Retrieved 24 January 2023.
- ↑ Venkatesh, Humsa S.; Tam, Lydia T.; Woo, Pamelyn J.; Lennon, James; Nagaraja, Surya; Gillespie, Shawn M.; Ni, Jing; Duveau, Damien Y.; Morris, Patrick J.; Zhao, Jean J.; Thomas, Craig J.; Monje, Michelle (September 20, 2017). "Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma". Nature. 549 (7673): 533–537. Bibcode:2017Natur.549..533V. doi:10.1038/nature24014. PMC 5891832. PMID 28959975. Retrieved 24 January 2023.
- ↑ Venkatesh, H. S.; Tam, L. T.; Woo, P. J.; Lennon, J.; Nagaraja, S.; Gillespie, S. M.; Ni, J.; Duveau, D. Y.; Morris, P. J.; Zhao, J. J.; Thomas, C. J.; Monje, M. (26 September 2019). "Electrical and synaptic integration of glioma into neural circuits". Nature. 573 (7673): 533–537. Bibcode:2017Natur.549..533V. doi:10.1038/nature24014. PMC 5891832. PMID 28959975. Retrieved 24 January 2023.
- ↑ Savchuk, Solomiia; Gentry, Kaylee; Wang, Wengang; Carleton, Elana; Yalçın, Belgin; Liu, Yin; Pavarino, Elisa C.; Labelle, Jenna; Toland, Angus M.; Woo, Pamelyn J.; Qu, Fangfei; Filbin, Mariella G.; Krasnow, Mark A.; Sabatini, Bernardo L.; Sage, Julien; Monje, Michelle; Venkatesh, Humsa S. (January 20, 2023). "Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression". bioRxiv. doi:10.1101/2023.01.19.524430. PMC 9882339 Check
|pmc=value (help). PMID 36711554 Check|pmid=value (help). Retrieved 24 January 2023. - ↑ Peloso, Marissa (2022-04-05). "Role of Neurons in the Tumor Microenvironment that Drive Cancer Growth". Brigham On a Mission. Retrieved 2023-10-02.
- ↑ Sun, Yiting (2018). "Humsa Venkatesh - Innovators Under 35". MIT Technology Review. Retrieved 24 January 2023.
- ↑ "Humsa Venkatesh - Science & SciLifeLab Prize". SciLifeLab. November 22, 2019. Retrieved 24 January 2023.
- ↑ Philippidis, Alex (June 2019). "Top 10 Under 40 of 2019" (39). Genetic Engineering & Biotechnology News (GEN). Retrieved 24 January 2023.
- ↑ "Humsa Venkatesh - Distinguished Scientist Award". The Sontag Foundation. Retrieved 24 January 2023.
External links
- Humsa Venkatesh publications indexed by Google Scholar
- Venkatesh Lab Website
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