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James Lamar Wittliff

From EverybodyWiki Bios & Wiki




James Lamar Wittliff
Born(1938-06-15)June 15, 1938
Taft, Texas
🏫 EducationUniversity of Texas at Austin
(B. A., Ph. D.)
Louisiana State University School of Medicine (M. S.)
💼 Occupation
Known forCreator of original QA surveys for Cooperative Clinical Trial Groups and the CAP for estrogen & progestin receptors[1][2][3] and Co-Developer with NEN/DuPont of First FDA approved test kits[4][5][6][7] of these cancer biomarkers

James Lamar Wittliff (born June 15th, 1938) also known as Jim Wittliff, is an American Biochemist and Professor Emeritus of Biochemistry & Molecular Genetics at the University of Louisville. He was Chairman of the Department of Biochemistry at the University of Louisville School of Medicine and Dentistry from 1976-1983.[8] Wittliff's laboratory was designated the National Reference Facility by the National Cancer Institute for performing quality assurance surveys of receptor biomarker testing in breast cancers for cooperative clinical trial groups in the United States and Canada.[1][2][3][5] He is the co-developer with NEN/DuPont[9] of the 1st FDA approved tests for quantifying levels of estrogen and progestin receptor proteins.[4][5][6][7]

Early life and education

Wittliff was born on June 15, 1938 in Taft, Texas,[10][11][12][13] of primarily Eastern European heritage. He is a 6th generation Texan and direct descendant of John Cryer (Crier), who was recruited to settle Texas as part of Stephen F. Austin's original 300 families. He, his brother Bill and their mother Laura moved to Blanco when they were boys.[10][11][12][13] In 1956, Wittliff graduated from San Marcos Academy, a college preparatory school that emphasized military discipline and training at the time.[14][15] After 2 years of studying Chemical Engineering at Texas Tech University where he was a student writer for The Daily Toreador [16][17], he received a bachelor's degree in chemistry from University of Texas at Austin. While at UT, Wittliff worked at Clyde Campbell University Shop and modeled to support his education. Wittliff then earned an M. S. Degree in Biochemistry at Louisiana State University, School of Medicine.[3] Wittliff's family moved to the University of Texas at Austin where he was awarded an National Defense Education Act (NDEA) Fellowship,[18] a program influenced by the launch of the Sputnik satellite by the Soviets. Wittliff received his Ph.D. degree at The University of Texas at Austin in 1967. He then received an NIH Postdoctoral Award to study in the Laboratory of Professor Francis T. Kenney in the Biology Division at Oak Ridge National Laboratory.[3]

Career

In 1969, Wittliff was recruited to the Department of Biochemistry at the University of Rochester School of Medicine as an assistant professor to work with Thomas C. Hall,[19] a co-founder of the sub-specialty of medical oncology, to develop the new Cancer Center. In 1975, Wittliff was promoted to Associate Professor of Biochemistry and Head on the Section on Endocrine Biochemistry in the Cancer Center. In 1976, the University of Louisville School of Medicine and Dentistry recruited Wittliff as Chairman of the Department of Biochemistry, a position he would hold until 1983. He was also actively involved in the development of the first Cancer Center there. Although Wittliff began developing assays for breast cancer that quantified estrogen and progestin receptor proteins using radio-labeled steroid ligands while at Rochester, it was in Louisville that he collaborated with New England Nuclear (NEN, later NEN/DuPont) to develop the first FDA-Approved Assay Kits for quantifying these clinically relevant biomarkers[4][5][6][7]

Upon arrival at the University of Louisville, Wittliff also established a clinical laboratory certified by the Commonwealth of Kentucky and CLIA to provide clinically relevant assays that quantified levels of estrogen and progestin receptor proteins for breast cancer management. This led Wittliff and his group to develop reference materials for these protein biomarkers and establishment of inter-laboratory Quality Assurance Programs for standardizing determinations of estrogen and progestin receptor proteins in breast cancer biopsies. Hundreds of laboratories engaged in cooperative clinical trials of breast cancer treatment by groups such as the NSABP[1],[20] CALGB[21],ECOG,[22] NCCTG,[23] SECSG[24] and SWOG[25] participated in NCI-sponsored QA Surveys established by Wittliff.[26][27] These QA programs were extended to the College of American Pathologists[28][29][30] and international investigators to standardize determinations of these cancer biomarkers for routine assessment by all clinical laboratories.[30]

Personal Life

He is the older of two children of Laura (née Sachtleben) Wittliff and William Albert Wittliff. Wittliff's brother William D. Wittliff was a noted American screenwriter and photographer. Various of Wittliff's and his brother's childhood experiences during World War II were depicted in the film Raggedy Man (1981).[10][11][12][13] While in college, Wittliff was a member of the Kappa Sigma fraternity and later received the John G. Tower Distinguished Alumni Award.[17] He married Theresa H. "Mitzie" Wittliff (née Hano) and had two sons. Later she also became his collaborator.[7] Wittliff is widely known as an Oenophile having served as President of the Kentucky Chapters of the American Wine Society and of the American Institute of Wine & Food. He was also a founding member of the Kentucky Chapter of Confrérie de la Chaîne des Rôtisseurs.

Awards and Accolades

1984  Elected Fellow of the National Academy of Clinical Biochemistry (now FADLM)[3]

1988 Distinguished Scientist Award, (Clinical Ligand Assay Society)[31]

1990-92 Co-Editor-in-Chief, Clinical Biochemistry[32]

1996-97 President, International Clinical Ligand Assay Society[3]

1998 Doctor of Medicine honoris causa (Leopold-Franzens-Universität Innsbruck, Austria)[33]

1998 University of Louisville Symposium honoring the career of James L. Wittliff

2001 American Association for Clinical Chemistry (Award for Outstanding Contributions to Clinical Chemistry in a Selected Area of Research)[3]

2001 American Association for Clinical Chemistry (Hall of Fame recognition)[3]

2002 Interagency Coordinating Committee on the Validation of Alternative Methods/ National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods- Expert Panel[34]

2004  Goldsmith Research Excellence Award, American Cancer Society, Kentucky Division[3]

2008  President's Award for Career Achievements: Outstanding Scholarship, Research and Creative Activity, University of Louisville[3]

2012  The CPT Paul W. Peña Outstanding Alumni Award - San Marcos Academy, San Marcos, TX[35]

2014 Morton K. Schwartz Award (for Significant Contributions in Cancer Research Diagnostics American Association for Clinical Chemistry)[36][3]

2015 - Present: Wittliff Lecture Series at San Marcos Academy honoring his career contributions[35]

2021  John G. Tower Distinguished Alumni Award, Texas Tech University, Kappa Sigma Fraternity[17]

References

  1. ↑ 1.0 1.1 1.2 Wickerham DL, O'Connell MJ, Costantino JP, Cronin WM, Paik S, Geyer CE Jr, Ganz PA, Petrelli N, Mamounas EP, Julian TB, Wolmark N. The half century of clinical trials of the National Surgical Adjuvant Breast And Bowel Project. Semin Oncol. 2008 Oct;35(5):522-9. doi: 10.1053/j.seminoncol.2008.07.005. PMID: 18929150; PMCID: PMC2583142. https://pubmed.ncbi.nlm.nih.gov/18929150/
  2. ↑ 2.0 2.1 "James L. Wittliff, Ph.D., FACB, to Present 'Predicting Breast Cancer Outcome with Gene Expression Signatures on the Ziplex(R) System' at the Association for Molecular Pathology Conference, October 30". 28 October 2008.
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 The Association for Diagnostics & Laboratory Medicine (ADLM) James Wittliff Biography.[1] Retrieved October 4, 2024.
  4. ↑ 4.0 4.1 4.2 New England Nuclear (NEN) Estrogen Receptor Assay Kits Approvable by FDA: Medical Devices, Diagnostics & Instrumentation Reports, p.3, January 19, 1981 (ISSN 0163-2426. https://portal.issn.org/resource/ISSN/0163-2426#)Retrieved October 4, 2024.
  5. ↑ 5.0 5.1 5.2 5.3 DeSombre, E. R., Carbone, P. P., Jensen, E. V., McGuire, W. L., Wells, S. A., Jr., Wittliff, J. L. and Lipsett, M. B. Steroid Receptors in Breast Cancer. New England J. Med., 301:1011-1012, 1979.[2]
  6. ↑ 6.0 6.1 6.2 https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/endo_docs/edprp-correction.pdf
  7. ↑ 7.0 7.1 7.2 7.3 "Conquering Breast Cancer Using Supercomputers, Data, and Mathematical Modeling | Association of American Universities (AAU)". 2 July 2024.
  8. ↑ History of the Department of Biochemistry and Molecular Genetics at the University of Louisville School of Medicine.[3] Retrieved October 4, 2024.
  9. ↑ New England Nuclear Archive in Science History Institute Muesum and Library [4] Retrieved October 4, 2024.
  10. ↑ 10.0 10.1 10.2 "Bill Wittliff". 12 June 2019.
  11. ↑ 11.0 11.1 11.2 "Bill Wittliff Obituary - Austin, TX".
  12. ↑ 12.0 12.1 12.2 Sandomir, Richard (13 June 2019). "Bill Wittliff, 'Lonesome Dove' Screenwriter and Son of Texas, Dies at 79". The New York Times.
  13. ↑ 13.0 13.1 13.2 "William D. Wittliff | Writer, Producer, Actor". IMDb.
  14. ↑ "Wittliff Lecture Series Coeducational Boarding School in Texas".
  15. ↑ https://smabears.myschoolapp.com/ftpimages/2320/download/download_3173766.pdf[permanent dead link]
  16. ↑ https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnewspapers.swco.ttu.edu%2Fbitstream%2Fhandle%2F20.500.12255%2F129269%2FThe%2520Toreador%2520%25281956-1959%2529_October%252030%252C%25201956.pdf%3Fsequence%3D3%26isAllowed%3Dy&data=05%7C02%7Cmichael.kotchev%40louisville.edu%7C7f90ccd6c2c14b6efec308dd4bb8eb64%7Cdd246e4a54344e158ae391ad9797b209%7C0%7C0%7C638749979910264412%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=D09fmur2bPJP4BXPNPtSBE3nfC6zJZ4YjZs3k7Lf8Kw%3D&reserved=0
  17. ↑ 17.0 17.1 17.2 "John G. Tower Award".
  18. ↑ Wittliff, James L.; Airth, Robert L. (1968). "Extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties". Biochemistry. 7 (2): 736–744. doi:10.1021/BI00842A032. PMID 4966932. Unknown parameter |s2cid= ignored (help)
  19. ↑ "Thomas C. Hall".
  20. ↑ Wolmark, N., Fisher, B. Adjuvant tamoxifen and chemotherapy in stage II breast cancer: Interim findings from NSABP protocol B-09. World J. Surg. 9, 750–755 (1985). https://doi.org/10.1007/BF01655190
  21. ↑ Kardinal CG, Perry MC, Korzun AH, Rice MA, Ginsberg S, Wood WC. Responses to chemotherapy or chemohormonal therapy in advanced breast cancer patients treated previously with adjuvant chemotherapy. A subset analysis of CALGB Study 8081. Cancer. 1988 Feb 1;61(3):415-9. doi: 10.1002/1097-0142(19880201)61:3<415::aid-cncr2820610302>3.0.co;2-q. PMID: 3338011. https://pubmed.ncbi.nlm.nih.gov/3338011/
  22. ↑ Raam S, Gelman R, Cohen JL, Bacharach A, Fishchinger AJ, Jacobson HI, Keshgegian AA, Konopka SJ, Wittliff JL. Estrogen receptor assay: interlaboratory and intralaboratory variations in the measurement of receptors using dextran-coated charcoal technique: a study sponsored by E.C.O.G. Eur J Cancer (1965). 1981 Jun;17(6):643-9. doi: 10.1016/0014-2964(81)90267-x. PMID: 6171430. https://pubmed.ncbi.nlm.nih.gov/6171430/
  23. ↑ Grothey A, Adjei AA, Alberts SR, Perez EA, Jaeckle KA, Loprinzi CL, Sargent DJ, Sloan JA, Buckner JC; North Central Cancer Treatment Group. North Central Cancer Treatment Group--achievements and perspectives. Semin Oncol. 2008 Oct;35(5):530-44. doi: 10.1053/j.seminoncol.2008.07.006. PMID: 18929151; PMCID: PMC6158781. https://pmc.ncbi.nlm.nih.gov/articles/PMC6158781/
  24. ↑ Vogel CL, East DR, Voigt W, Thomsen S. Response to tamoxifen in estrogen receptor-poor metastatic breast cancer. Cancer. 1987 Sep 15;60(6):1184-9. doi: 10.1002/1097-0142(19870915)60:6<1184::aid-cncr2820600605>3.0.co;2-#. PMID: 3304611. https://acsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/1097-0142%2819870915%2960%3A6%3C1184%3A%3AAID-CNCR2820600605%3E3.0.CO%3B2-%23
  25. ↑ Fisher B, Redmond CK, Fisher ER. Evolution of knowledge related to breast cancer heterogeneity: a 25-year retrospective. J Clin Oncol. 2008 May 1;26(13):2068-71. doi: 10.1200/JCO.2007.14.1804. PMID: 18445835. https://pubmed.ncbi.nlm.nih.gov/18445835/
  26. ↑ Wittliff, J. L., Fisher, B., and Durant, J. R. Establishment of Uniformity in Steroid Receptor Analyses Used In Cooperative Clinical Trials of Breast Cancer Treatment. In: B. Henningsen, F. Linder and C. Steichele (eds.), Recent Results in Cancer Research, Vol. 71, pp. 198-206, Heidelberg: Springer-Verlag, 1980. Retrieved October 7, 2024.
  27. ↑ Wittliff, J. L., Brown, A. M. and Fisher, B. Establishment of Uniformity in Steroid Receptor Determinations for Protocol B-09 of the National Surgical Adjuvant Breast Project. In: G. A. Sarfaty, A. R. Nash and D. D. Keightley (eds.), Estrogen Receptor Assays in Breast Cancer: Laboratory Discrepencies and Quality Assurance, pp. 27-42, New York: Masson Publishing USA, Inc., 1981. https://pubmed.ncbi.nlm.nih.gov/6988915/
  28. ↑ https://dctd.cancer.gov/NewsEvents/DCTD_2010_Program_Accomplishments.pdf
  29. ↑ Oxley, D. K., et al. Precision in Estrogen and Progesterone Receptor Assays: Results of the First CAP Pilot Survey. Amer. J. Clin. Pathol., 78:587-596, 1982. https://pubmed.ncbi.nlm.nih.gov/7137099/
  30. ↑ 30.0 30.1 Hammond, M.E.H., et al. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer. (Unabridged Manuscript at www.ASCO.org) Arch. Pathol. Lab. Med. 134 (6): 907-22, 2010. PMID: 20524868
  31. ↑ Chase, Grafton. CLAS at 20: A History. Journal of Clinical Immunoassay, 17 (1):17-23, 1994. Retrieved October 7, 2024.
  32. ↑ "NACB History".
  33. ↑ Compiled by David E. Bruns Editor , The Clinical Chemist, Clinical Chemistry, Volume 47, Issue 7, 1 July 2001, Pages 1335–1342, https://doi.org/10.1093/clinchem/47.7.1335.[5] Retrieved October 4, 2024.
  34. ↑ https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
  35. ↑ 35.0 35.1 San Marcos Academy[6] Retrieved October 7, 2024.
  36. ↑ ADLM Merit Awards: The Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics.[7] Retrieved October 4, 2024.

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