James M. A. Turner
| James M. A. Turner FMedSci FRS | |
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| 🌐 Website | www |
James M(ichael) A(ndrew) Turner FMedSci FRS is a British geneticist who works as a Principal Group Leader at the Francis Crick Institute in London.
Education
Turner was educated on the MB PhD programme at University College London, receiving his PhD from the MRC National Institute for Medical Research.
Research and Career
After practicing briefly as a physician, Turner returned to the MRC National Institute for Medical Research, where he was a postdoc and then Group Leader. He later moved to the Francis Crick Institute, where he is a Principal Group Leader.[1] His research interests focus on the genetics, epigenetics and evolution of sex chromosomes in eutherians and marsupials. His lab has identified how X and Y genes control fertility[2][3] and designed proof-of-principle methods to reverse infertility caused by sex chromosome aneuploidy.[4] He has also championed the use of the opossum in research, making major discoveries on the evolution of X-chromosome inactivation and embryo development.[5][6][7] Furthermore, his team generated the first system to single-sex mouse litters.[8] This approach could help reduce production and culling of animals of the unrequired sex in research and agriculture, e.g., the egg laying industry.
Awards and honors
Turner was elected a member of the European Molecular Biology Organisation (EMBO) in 2019, a Fellow of the Academy of Medical Sciences (FMedSci) in 2021, and a Fellow of the Royal Society (FRS) in 2023.[9]
Category:Members of the European Molecular Biology Organization
Category:British fellows of the Royal Society
Category:Fellows of the Academy of Medical Sciences (United Kingdom)
References
- ↑ https://www.crick.ac.uk/research/find-a-researcher/james-turner
- ↑ Subrini, Jeremie; Varsally, Wazeer; Balsells, Irina Balaguer; Bensberg, Maike; Sioutas, Georgios; Ojarikre, Obah; Maciulyte, Valdone; Gylemo, Björn; Crawley, Katharine; Courtis, Katherine; de Rooij, Dirk G.; Turner, James M. A. (24 January 2025). "Systematic identification of Y-chromosome gene functions in mouse spermatogenesis". Science. 387 (6732): 393–400. Bibcode:2025Sci...387..393S. doi:10.1126/science.ads6495. PMC 7617377 Check
|pmc=value (help). PMID 39847625 Check|pmid=value (help). - ↑ Mueller, Jacob L; Mahadevaiah, Shantha K; Park, Peter J; Warburton, Peter E; Page, David C; Turner, James M A (June 2008). "The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression". Nature Genetics. 40 (6): 794–799. Bibcode:2008NaGen..40..794M. doi:10.1038/ng.126. PMC 2740655. PMID 18454149.
- ↑ Hirota, Takayuki; Ohta, Hiroshi; Powell, Benjamin E.; Mahadevaiah, Shantha K.; Ojarikre, Obah A.; Saitou, Mitinori; Turner, James M. A. (September 2017). "Fertile offspring from sterile sex chromosome trisomic mice". Science. 357 (6354): 932–935. Bibcode:2017Sci...357..932H. doi:10.1126/science.aam9046. PMC 5581950. PMID 28818972.
- ↑ Grant, Jennifer; Mahadevaiah, Shantha K.; Khil, Pavel; Sangrithi, Mahesh N.; Royo, Hélène; Duckworth, Janine; McCarrey, John R.; VandeBerg, John L.; Renfree, Marilyn B.; Taylor, Willie; Elgar, Greg; Camerini-Otero, R. Daniel; Gilchrist, Mike J.; Turner, James M. A. (July 2012). "Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation". Nature. 487 (7406): 254–258. Bibcode:2012Natur.487..254G. doi:10.1038/nature11171. PMC 3484893. PMID 22722828.
- ↑ Leeke, Bryony J.; Varsally, Wazeer; Ogushi, Sugako; Zohren, Jasmin; Menchero, Sergio; Courtois, Aurélien; Snell, Daniel M.; Teissandier, Aurélie; Ojarikre, Obah; Mahadevaiah, Shantha K.; Decarpentrie, Fanny; Oakey, Rebecca J.; VandeBerg, John L.; Turner, James M. A. (26 June 2025). "Divergent DNA methylation dynamics in marsupial and eutherian embryos". Nature. 642 (8069): 1073–1079. Bibcode:2025Natur.642.1073L. doi:10.1038/s41586-025-08992-2. PMC 12221971 Check
|pmc=value (help). PMID 40369084 Check|pmid=value (help). - ↑ Mahadevaiah, Shantha K.; Sangrithi, Mahesh N.; Hirota, Takayuki; Turner, James M. A. (22 October 2020). "A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation". Nature. 586 (7830): 612–617. Bibcode:2020Natur.586..612M. doi:10.1038/s41586-020-2629-6. PMC 7116401 Check
|pmc=value (help). PMID 32814901 Check|pmid=value (help). - ↑ Douglas, Charlotte; Maciulyte, Valdone; Zohren, Jasmin; Snell, Daniel M.; Mahadevaiah, Shantha K.; Ojarikre, Obah A.; Ellis, Peter J. I.; Turner, James M. A. (3 December 2021). "CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes". Nature Communications. 12 (1). Bibcode:2021NatCo..12.6926D. doi:10.1038/s41467-021-27227-2. PMC 8642469 Check
|pmc=value (help). PMID 34862376 Check|pmid=value (help). Unknown parameter|article-number=ignored (help) - ↑ "Dr James Turner FMedSci FRS | Royal Society Fellow".
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