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Jan Huisken

From EverybodyWiki Bios & Wiki


Jan Huisken (born 26 November 1974 in Göttingen, Germany) is a German physicist. Since 2016, he has been a principal investigator and leader of the Medical Engineering theme in the Morgridge Institute for Research at the University of Wisconsin, Madison. Huisken is considered a co-founder of modern light sheet microscopy and received the Medal for Light Microscopy 2017 from the Royal Microscopical Society (RMS)[1] for his outstanding work.

Life

Huisken studied Physics at Göttingen University and Heidelberg University. Subsequently, he was a doctoral candidate in the International PhD Program of the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. From 2000 until 2004 he worked on optical tweezers and high-resolution fluorescence microscopy in the lab of Ernst H.K. Stelzer. His work focused primarily on multidimensional light sheet microscopy (also Selective Plane Illumination Microscopy, SPIM) and its applications in the life sciences. Huisken completed this work by receiving a doctoral degree in 2004 from Freiburg University. For one of the first applications of light sheet microscopy, Huisken turned his attention towards Medaka development in the lab of Joachim Wittbrodt.[2] Huisken moved to San Francisco in 2005 for a postdoctoral Human Frontier Science Program (HFSP) fellowship in the lab of Didier Y.R. Stainier at the University of California. Using his self-engineered microscope, he researched cardiovascular morphogenesis and function in zebrafish.[3] Huisken achieved key breakthroughs in the application of multidimensional in vivo fluorescence imaging to become an internationally recognized microscope developer and cross-disciplinary biophysicist.

From 2010 until 2016 Huisken was an independent group leader at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany. Additionally, in 2013 he joined the Center for Systems Biology in Dresden. He has been a principal investigator and leader of the Medical Engineering theme at the Morgridge Institute for Research at the University of Wisconsin in Madison since 2016. Since 2018 he is also a Visiting Professor in the Department of Integrative Biology at the University of Wisconsin.

Huisken is married and has two children.

Awards

Literature

  • Mattmiller, Brian: A novel data storage project unshackles microscopy from data overload. College of Engineering, UW-Madison, 19 Oct 2017.[7]
  • Mattmiller, Brian. Jan Huisken: Building a better, smarter microscope. Morgridge Institute for Research, News & Stories, 7 Mar 2017.[8]
  • Mattmiller, Brian: Focus on new faculty: Jan Huisken, developing new tools for biological imaging. College of Engineering, UW-Madison, News Details, 12 Mar 2016.[9]
  • Mattmiller, Brian. New Morgridge research team leader foresees era of 'smart microscopes'. Morgridge Institute for Research, News & Stories, 10 Mar 2016.[10]
  • Herzschlag in 3D. Max-Planck-Forscher beobachten Zebrafisch-Herz bei der Arbeit. Max-Planck-Gesellschaft, Newsroom, 22 Jul 2014.[11]
  • Fundamentals of Embryo Development uncovered in real time. High-speed light sheet microscopy. Andor, Learning Academy.[12]

Selected Publications

  • Power, R. M., & Huisken, J. (2017). A guide to light-sheet fluorescence microscopy for multiscale imaging. Nature methods, 14(4), 360.[13]
  • Jahr, W., Schmid, B., Schmied, C., Fahrbach, F. O., & Huisken, J. (2015). Hyperspectral light sheet microscopy. Nature communications, 6, 7990.[14]
  • Scherf, N., & Huisken, J. (2015). The smart and gentle microscope. Nature biotechnology, 33(8), 815.[15]
  • Bassi, A., Schmid, B., & Huisken, J. (2015). Optical tomography complements light sheet microscopy for in toto imaging of zebrafish development. Development, 142(5), 1016–1020.[16]
  • Mickoleit, M., Schmid, B., Weber, M., Fahrbach, F. O., Hombach, S., Reischauer, S., & Huisken, J. (2014). High-resolution reconstruction of the beating zebrafish heart. Nature methods, 11(9), 919.[17]
  • Schmid, B., Shah, G., Scherf, N., Weber, M., Thierbach, K., Campos, C. P., ... & Huisken, J. (2013). High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics. Nature communications, 4, 2207.[18]
  • Kaufmann, A., Mickoleit, M., Weber, M., & Huisken, J. (2012). Multilayer mounting enables long-term imaging of zebrafish development in a light sheet microscope. Development, 139(17), 3242–3247.[19]
  • Arrenberg, A. B., Stainier, D. Y., Baier, H., & Huisken, J. (2010). Optogenetic control of cardiac function. Science, 330(6006), 971–974.[20]
  • Herbert, S. P., Huisken, J., Kim, T. N., Feldman, M. E., Houseman, B. T., Wang, R. A., ... & Stainier, D. Y. (2009). Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science, 326(5950), 294–298.[21]
  • Huisken, J., & Stainier, D. Y. (2009). Selective plane illumination microscopy techniques in developmental biology. Development, 136(12), 1963–1975.[22]
  • Huisken, J., & Stainier, D. Y. (2007). Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM). Optics letters, 32(17), 2608–2610.[23]
  • Huisken, J., Swoger, J., Del Bene, F., Wittbrodt, J., & Stelzer, E. H. (2004). Optical sectioning deep inside live embryos by selective plane illumination microscopy. Science, 305(5686), 1007–1009.[24]

References

  1. ↑ Mel. "Medal Series". www.rms.org.uk. Retrieved 2018-10-21.
  2. ↑ Huisken, Jan; Swoger, Jim; Bene, Filippo Del; Wittbrodt, Joachim; Stelzer, Ernst H. K. (2004-08-13). "Optical Sectioning Deep Inside Live Embryos by Selective Plane Illumination Microscopy". Science. 305 (5686): 1007–1009. CiteSeerX 10.1.1.456.2250. doi:10.1126/science.1100035. ISSN 0036-8075. PMID 15310904.
  3. ↑ Huisken, Jan; Stainier, Didier Y. R. (2007-09-01). "Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM)". Optics Letters. 32 (17): 2608–2610. doi:10.1364/OL.32.002608. ISSN 1539-4794.
  4. ↑ Mel. "Medal Series". www.rms.org.uk. Retrieved 2018-10-21.
  5. ↑ "ERC FUNDED PROJECTS". ERC: European Research Council. Retrieved 2018-10-21.
  6. ↑ User, Super. "Twenty-seven researchers named as EMBO Young Investigators". EMBO. Archived from the original on 2018-06-16. Retrieved 2018-10-21.
  7. ↑ "A novel data storage project unshackles microscopy from data overload - College of Engineering - University of Wisconsin-Madison". College of Engineering - University of Wisconsin-Madison. 2017-10-19. Retrieved 2018-10-21.
  8. ↑ "Jan Huisken: Building a better, smarter microscope". Retrieved 2018-10-21.
  9. ↑ "Focus on new faculty: Jan Huisken, developing new tools for biological imaging - College of Engineering - University of Wisconsin-Madison". College of Engineering - University of Wisconsin-Madison. 2016-03-12. Retrieved 2018-10-21.
  10. ↑ "New Morgridge research team leader foresees era of 'smart microscopes'". Retrieved 2018-10-21.
  11. ↑ "Herzschlag in 3D". www.mpg.de (in Deutsch). Retrieved 2018-10-21.
  12. ↑ "Fundamentals of Embryo Development uncovered in real time - Andor Learning Centre". Oxford Instruments. Retrieved 2018-10-21.
  13. ↑ Power, Rory (2017). "A guide to light-sheet fluorescence microscopy for multiscale imaging". Nature Methods. 14 (4): 360–373. doi:10.1038/nmeth.4224. PMID 28362435.
  14. ↑ Jahr, Wiebke; Schmid, Benjamin; Schmied, Christopher; Fahrbach, Florian O.; Huisken, Jan (2015-09-02). "Hyperspectral light sheet microscopy". Nature Communications. 6 (1): 7990. doi:10.1038/ncomms8990. ISSN 2041-1723. PMC 4569691. PMID 26329685.
  15. ↑ Scherf, Nico; Huisken, Jan (August 2015). "The smart and gentle microscope". Nature Biotechnology. 33 (8): 815–818. doi:10.1038/nbt.3310. ISSN 1087-0156. PMID 26252136.
  16. ↑ Bassi, Andrea; Schmid, Benjamin; Huisken, Jan (2015-03-01). "Optical tomography complements light sheet microscopy for in toto imaging of zebrafish development". Development. 142 (5): 1016–1020. doi:10.1242/dev.116970. ISSN 0950-1991. PMC 4352980. PMID 25655702.
  17. ↑ Mickoleit, Michaela; Schmid, Benjamin; Weber, Michael; Fahrbach, Florian O; Hombach, Sonja; Reischauer, Sven; Huisken, Jan (2014-07-20). "High-resolution reconstruction of the beating zebrafish heart". Nature Methods. 11 (9): 919–922. doi:10.1038/nmeth.3037. ISSN 1548-7091. PMID 25042787.
  18. ↑ Schmid, Benjamin; Shah, Gopi; Scherf, Nico; Weber, Michael; Thierbach, Konstantin; Campos, Citlali Pérez; Roeder, Ingo; Aanstad, Pia; Huisken, Jan (2013-07-25). "High-speed panoramic light-sheet microscopy reveals global endodermal cell dynamics". Nature Communications. 4 (1): 2207. doi:10.1038/ncomms3207. ISSN 2041-1723. PMC 3731668. PMID 23884240.
  19. ↑ Kaufmann, Anna; Mickoleit, Michaela; Weber, Michael; Huisken, Jan (2012-09-01). "Multilayer mounting enables long-term imaging of zebrafish development in a light sheet microscope". Development. 139 (17): 3242–3247. doi:10.1242/dev.082586. ISSN 0950-1991. PMID 22872089.
  20. ↑ Arrenberg, Aristides B.; Stainier, Didier Y. R.; Baier, Herwig; Huisken, Jan (2010-11-12). "Optogenetic Control of Cardiac Function". Science. 330 (6006): 971–974. doi:10.1126/science.1195929. ISSN 0036-8075. PMID 21071670.
  21. ↑ Herbert, Shane P.; Huisken, Jan; Kim, Tyson N.; Feldman, Morri E.; Houseman, Benjamin T.; Wang, Rong A.; Shokat, Kevan M.; Stainier, Didier Y. R. (2009-10-09). "Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation". Science. 326 (5950): 294–298. doi:10.1126/science.1178577. ISSN 0036-8075. PMC 2865998. PMID 19815777.
  22. ↑ Huisken, Jan; Stainier, Didier Y. R. (2009-06-15). "Selective plane illumination microscopy techniques in developmental biology". Development. 136 (12): 1963–1975. doi:10.1242/dev.022426. ISSN 0950-1991. PMC 2685720. PMID 19465594.
  23. ↑ Huisken, Jan; Stainier, Didier Y. R. (2007-09-01). "Even fluorescence excitation by multidirectional selective plane illumination microscopy (mSPIM)". Optics Letters. 32 (17): 2608–2610. doi:10.1364/OL.32.002608. ISSN 1539-4794.
  24. ↑ Huisken, Jan; Swoger, Jim; Bene, Filippo Del; Wittbrodt, Joachim; Stelzer, Ernst H. K. (2004-08-13). "Optical Sectioning Deep Inside Live Embryos by Selective Plane Illumination Microscopy". Science. 305 (5686): 1007–1009. CiteSeerX 10.1.1.456.2250. doi:10.1126/science.1100035. ISSN 0036-8075. PMID 15310904.


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