Jeffrey C. Magee
| Jeffrey C. Magee | |
|---|---|
| Born | United States |
| 🎓 Alma mater | Louisiana State University (B.S.) Tulane University (Ph.D.) |
| 💼 Occupation | |
| Known for | Behavioral Timescale Synaptic Plasticity (BTSP) |
| 🌐 Website | Magee Lab website |
Jeffrey C. Magee is an American neuroscientist and investigator of the Howard Hughes Medical Institute (HHMI). He is a professor in the Department of Neuroscience at Baylor College of Medicine and holds the Cullen Foundation Distinguished Endowed Chair at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital.[1]
Education and career
Magee earned his Bachelor of Science degree from Louisiana State University and his Ph.D. from Tulane University.[2]
He served as a group leader at the Janelia Research Campus of HHMI, where he led research into hippocampal and cortical circuits.[3] He later joined Baylor College of Medicine, where he continues to investigate the synaptic and circuit-level mechanisms of learning and memory.[4]
Research
Magee is known for his work on synaptic plasticity and neural circuit function, particularly in the hippocampus and entorhinal cortex.[citation needed] His laboratory introduced the concept of behavioral timescale synaptic plasticity (BTSP), a form of plasticity that operates over several seconds — a timescale more aligned with behavioral learning — rather than the millisecond windows typical of classical spike-timing dependent plasticity.[citation needed]
In a widely cited 2017 paper published in Science, Magee and colleagues demonstrated that synaptic strengthening in hippocampal CA1 neurons can be driven by dendritic plateau potentials occurring seconds after presynaptic input, forming place fields in a single trial.[5]
In 2020, Magee co-authored a review in the Annual Review of Neuroscience that contextualized BTSP among other forms of synaptic plasticity and discussed its implications for memory formation and cortical learning.[6]
His research combines electrophysiology, two-photon calcium imaging, optogenetics, and computational modeling to study how learning and experience shape neural representations.[1]
Affiliations
- Professor, Department of Neuroscience, Baylor College of Medicine
- Investigator, Howard Hughes Medical Institute
- Former Group Leader, Janelia Research Campus
See also
References
- ↑ 1.0 1.1 "Jeffrey C. Magee". Baylor College of Medicine. Retrieved 2025-10-21.
- ↑ "Jeffrey C. Magee, PhD". HHMI. Retrieved 2025-10-21.
- ↑ "Magee Lab". Janelia Research Campus. Retrieved 2025-10-21.
- ↑ "Jeffrey C. Magee, Ph.D." Texas Children's. Retrieved 2025-10-21.
- ↑ Bittner, K.C.; Milstein, A.D.; Grienberger, C.; Romani, S.; Magee, J.C. (2017). "Behavioral time scale synaptic plasticity underlies CA1 place fields". Science. 357 (6355): 1033–1036. doi:10.1126/science.aan3846. PMC 7289271 Check
|pmc=value (help). PMID 28860209. - ↑ Magee, J.C.; Grienberger, C. (2020). "Synaptic Plasticity Forms and Functions". Annual Review of Neuroscience. 43 (5): 95–117. doi:10.1146/annurev-neuro-090919-022842. PMC 7212531 Check
|pmc=value (help). PMID 32421042 Check|pmid=value (help).
Category:American neuroscientists
Category:Baylor College of Medicine faculty
Category:Howard Hughes Medical Investigators
Category:Louisiana State University alumni
Category:Tulane University alumni
Category:Living people
Category:Year of birth missing (living people)
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