Joachim W. Engels
Joachim W. O. Engels (* 19 March 1944 in Wiesbaden, Germany; † 10 July 2018 in Kronberg, Germany) was a German chemist.
Life[edit]
Joachim Engels studied chemistry between 1964 and 1968 at the FU Berlin, the Ludwig-Maximilians-University Munich and the University of Regensburg, where he also completed his doctorate in 1972. After a postdoctoral stay at Stanford University with Eugene van Tamelen, Engels moved to the University of Constance in 1973, where he worked on his habilitation on nucleotide chemistry, which he completed in 1979. His habilitation was followed by another stay in the USA with Marvin H. Caruthers at the University of Colorado. From 1982 onwards, Engels headed a DNA synthesis group at Hoechst AG in Frankfurt.
In 1985 he was appointed to the Johann Wolfgang Goethe University Frankfurt am Main, where he held a C4 professorship in bioorganic chemistry from 1993 until his retirement in 2011. In 2012 he was appointed Senior Professor.
Joachim Engels was married and father of three children.
Work[edit]
Engels' main research interest[1] was in nucleotide chemistry, in particular the synthesis of modified oligonucleotides[2], and their analysis[3][4] and possible therapeutic applications[5][6]. Joachim Engels was founder and from 2001 to 2007 speaker of the Collaborative Research Center 579 "RNA-Ligand Interactions" of the German Research Foundation and from 2005 to 2006 president of the International Society of Nucleotides and Nucleic Acids (IS3NA).[7]
He has held several visiting professorships, including Chiba Institute, Japan 1989; Hokkaido University, Japan 1998; Shandong University, China 2004; Cadi Ayyad University, Morocco 2010; and the University of the Witwatersrand, South Africa 2012.
In 2013 he was elected President of the Scientific Society at Goethe University and held this position until his death.
Works[edit]
- as an ed. together with Friedrich Lottspeich: Bioanalytik. Spektrum Akademischer Verlag, 2006, ISBN 978-3-8274-1520-2 Search this book on
.. - as an ed. together with Friedrich Lottspeich: Bioanalytics. Wiley-VCH, Weinheim 2018, ISBN 978-3-527-33919-8 Search this book on ..
Weblinks[edit]
- Literature by and about Joachim W. Engels in the catalogue of the German National Library
- Literature by and about Joachim W. Engels in the bibliographic database WorldCat
- Website of the working group of Engels
Itemisation[edit]
- Mourning announcement Joachim W. O. Engels, FAZ of 14 July 2018
- Johann Wolfgang Goethe University Frankfurt am Main: Obituary Joachim W. O. Engels, FAZ of 14 July 2018
References[edit]
- ↑ "Research Topics Joachim Engels" (PDF). Retrieved 2019-01-24.
- ↑ Parsch, Jörg; Engels, Joachim W. (2002-05-01). "C−F···H−C Hydrogen Bonds in Ribonucleic Acids". Journal of the American Chemical Society. 124 (20): 5664–5672. doi:10.1021/ja012116g. ISSN 0002-7863.
- ↑ Nordhoff, E.; Karas, M.; Cramer, R.; Hahner, S.; Hillenkamp, F.; Kirpekar, F.; Lezius, A.; Muth, J.; Meier, C. (1995). "Direct mass spectrometric sequencing of low-picomole amounts of oligodeoxynucleotides with up to 21 bases by matrix-assisted laser desorption/ionization mass spectrometry". Journal of Mass Spectrometry. 30 (1): 99–112. doi:10.1002/jms.1190300116. ISSN 1096-9888.
- ↑ Schiemann, Olav; Piton, Nelly; Mu, Yuguang; Stock, Gerhard; Engels, Joachim W.; Prisner, Thomas F. (2004-05-01). "A PELDOR-Based Nanometer Distance Ruler for Oligonucleotides". Journal of the American Chemical Society. 126 (18): 5722–5729. doi:10.1021/ja0393877. ISSN 0002-7863.
- ↑ Kjems, Jørgen; Wengel, Jesper; Herdewijn, Piet; Engels, Joachim W.; Zerial, Marino; Chattopadhyaya, Jyoti; Meyer, Thomas F.; Fava, Eugenio; Mikhailov, Sergey N. (2009-05-01). "A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity". Nucleic Acids Research. 37 (9): 2867–2881. doi:10.1093/nar/gkp106. ISSN 0305-1048. PMC 2685080. PMID 19282453.
- ↑ Kjems, Jørgen; Wengel, Jesper; Herdewijn, Piet; Engels, Joachim W.; Chattopadhyaya, Jyoti; Wengel, Suzy L.; Smicius, Romualdas; Odadzic, Dalibor; Langkjær, Niels (2010-09-01). "A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects". Nucleic Acids Research. 38 (17): 5761–5773. doi:10.1093/nar/gkq341. ISSN 0305-1048. PMC 2943616. PMID 20453030.
- ↑ "History and Presidents of the IS3NA since Foundation". Retrieved 2019-01-24.
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