Anna Katharina Simon
| Prof Anna Katharina Simon PhD | |
|---|---|
| Born | |
| 🎓 Alma mater | DRFZ Berlin |
| 💼 Occupation | Professor of Immunology at University of Oxford |
| Known for | Autophagy in the immune system |
| 🏅 Awards | Ita Askonas award 2018 |
Katja A Simon AKA Anna Katharina Simon, PhD is currently the professor of immunology at the University of Oxford and a principal investigator at the Kennedy Institute of Rheumatology in Oxford.[1] where she studies the role of autophagy in the immune system[2]
Career[edit]
Simon trained at the Deutsches Rheumaforschungszentrum (DRFZ) Berlin under Avrion Mitchison then moved to the Centre d'Immunologie Marseille Luminy for her first postdoc position. She moved to the University of Oxford for her second postdoc were started her own group at the Weatherall Institute of Molecular Medicine. Simon is currently based at the Kennedy Institute of Rheumatology.[1]
Notable Work[edit]
Autoimmune diseases[edit]
During her PhD at the DRFZ Berlin Simon discovered that Th1 cytokines are predominant in human autoimmune diseases[3][4]
Autophagy in the hemato-immune system[edit]
Simon's work focuses on the importance of autophagy, one of the main cellular degradation pathays[5], in the development and maintenance of the hemato-immune system. Simon's group helped to clarify the role of autophagy in the maintenance of red blood cells[6], hematopoietic stem cells[7], memory T cells[8] and in the maturation of neutrophils[9]. Her latest work highligt how a decrease in autophagy can lead to immune senescence.[10][11]
Honors and awards[edit]
In 2018 Simon received the Ita Askonas award that acknowledges female group leaders in immunology.
- ↑ 1.0 1.1 "Anna Katharina (Katja) A Simon — The Kennedy Institute of Rheumatology". www.kennedy.ox.ac.uk. Retrieved 2020-03-07.
- ↑ "Anna Katharina (Katja) A Simon — University of Oxford, Medical Sciences Division". www.medsci.ox.ac.uk. Retrieved 2020-03-07.
- ↑ Simon, A. K.; Seipelt, E.; Sieper, J. (1994-08-30). "Divergent T-cell cytokine patterns in inflammatory arthritis". Proceedings of the National Academy of Sciences. 91 (18): 8562–8566. Bibcode:1994PNAS...91.8562S. doi:10.1073/pnas.91.18.8562. ISSN 0027-8424. PMC 44646. PMID 8078923.
- ↑ Simon, A. K.; Seipelt, E.; Wu, P.; Wenzel, B.; Braun, J.; Sieper, J. (2008-06-28). "Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis patients: predominance of the Th1 subset". Clinical & Experimental Immunology. 94 (1): 122–126. doi:10.1111/j.1365-2249.1993.tb05988.x. PMC 1534378. PMID 8403493.
- ↑ Kaur, Jasvinder; Debnath, Jayanta (August 2015). "Autophagy at the crossroads of catabolism and anabolism". Nature Reviews Molecular Cell Biology. 16 (8): 461–472. doi:10.1038/nrm4024. ISSN 1471-0072. PMID 26177004.
- ↑ Mortensen, Monika; Simon, Anna Katharina (April 2010). "Nonredundant role of Atg7 in mitochondrial clearance during erythroid development". Autophagy. 6 (3): 423–425. doi:10.4161/auto.6.3.11528. ISSN 1554-8627. PMID 20215867.
- ↑ Mortensen, Monika; Soilleux, Elizabeth J.; Djordjevic, Gordana; Tripp, Rebecca; Lutteropp, Michael; Sadighi-Akha, Elham; Stranks, Amanda J.; Glanville, Julie; Knight, Samantha; W. Jacobsen, Sten-Eirik; Kranc, Kamil R. (2011-03-14). "The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance". The Journal of Experimental Medicine. 208 (3): 455–467. doi:10.1084/jem.20101145. ISSN 1540-9538. PMC 3058574. PMID 21339326.
- ↑ Puleston, Daniel J; Zhang, Hanlin; Powell, Timothy J; Lipina, Elina; Sims, Stuart; Panse, Isabel; Watson, Alexander S; Cerundolo, Vincenzo; Townsend, Alain RM; Klenerman, Paul; Simon, Anna Katharina (2014-11-11). "Autophagy is a critical regulator of memory CD8+ T cell formation". eLife. 3: e03706. doi:10.7554/eLife.03706. ISSN 2050-084X. PMC 4225493. PMID 25385531.
- ↑ Riffelmacher, Thomas; Clarke, Alexander; Richter, Felix C.; Stranks, Amanda; Pandey, Sumeet; Danielli, Sara; Hublitz, Philip; Yu, Zhanru; Johnson, Errin; Schwerd, Tobias; McCullagh, James (September 2017). "Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation". Immunity. 47 (3): 466–480.e5. doi:10.1016/j.immuni.2017.08.005. PMC 5610174. PMID 28916263.
- ↑ Robinson, Ann (2016-10-10). "Pomegranates, turmeric and red grapes: the key to long life?". The Guardian. ISSN 0261-3077. Retrieved 2020-03-07.
- ↑ Zhang, Hanlin; Alsaleh, Ghada; Feltham, Jack; Sun, Yizhe; Napolitano, Gennaro; Riffelmacher, Thomas; Charles, Philip; Frau, Lisa; Hublitz, Philip; Yu, Zhanru; Mohammed, Shabaz (October 2019). "Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence". Molecular Cell. 76 (1): 110–125.e9. doi:10.1016/j.molcel.2019.08.005. PMC 6863385 Check
|pmc=value (help). PMID 31474573.
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