Keith Mostov

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Keith E. Mostov is an academic cell and developmental biologist, who has been on the faculty of the University of California, San Francisco, School of Medicine since 1989.

Biography

Mostov was born in New York City in 1956. He received an AB from the University of Chicago in 1976. During 1976–77, he was a Rhodes Scholar at New College, Oxford.

Mostov received a PhD in Biological Science from the Rockefeller University in the laboratory of Nobel laureate Günter Blobel in 1983,

and an MD from Weill Cornell Medicine in 1984. He was a Whitehead Fellow at the Whitehead Institute of MIT from 1984 to 1989.

In 1989, Mostov joined the faculty of the University of California, San Francisco, School of Medicine, where he is currently a Professor in the Departments of Anatomy, and Biochemistry/Biophysics.

Contributions to Science

1. Mostov and colleagues discovered the Polymeric Immunoglobulin Receptor (pIgR).

https://en.wikipedia.org/wiki/Polymeric_immunoglobulin_receptor

They proposed that newly made pIgR is first sent to the basolateral surface of the cell, where it can bind polymeric IgA or IgM (pIg). The pIg-pIgR complex is then endocytosed, transcytosed across the cell in vesicles, and exocytosed at the apical surface, where the Secretory Component is proteolytically cleaved off from the pIgR, releasing Secretory Component together with the pIg.

2. Mostov and colleagues cloned and sequenced the pIgR. They found that the Secretory Component portion of the pIgR contains five immunoglobulin-like domains.

3. Mostov and colleagues used the pIgR to study the signals for membrane traffic and transcytosis in polarized epithelial cells.

They showed that the cytoplasmic domain of the pIgR contains a signal for basolateral sorting.

They further found that binding of IgA to the pIgR initiates a signaling cascade that stimulates transcytosis.

4. Neil E. Simister and Mostov cloned and sequenced the Neonatal Fc Receptor (FcRn), the receptor responsible for transcytosis of IgG and for prolonging the half-life of IgG and serum albumin in the circulation.

5. Mostov and colleagues studied how polarized epithelial cells form three-dimensional structures with lumens and tubules.

They showed that phosphoinositide phospholipids are identity determinants for the polarized domains of epithelial cells.

6. Mostov and colleagues showed how simple rules cause different branching patterns in kidney as compared to other branching tubular organs.

Honors

Honors received by Mostov include:

Rhodes Scholar

Searle Scholar

American Society for Cell Biology ASCB Fellow.

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