Kept on Wikipedia:Kuo-Chen Chou

Kuo-Chen Chou (周国城) is a Chinese-born American Biophysics and Bioinformatics scientist. As of October 2017, Chou has published over 580 papers with H-index of 130. He has been named an ISI Highly Cited Researcher four times. In 2009 he was named by ScienceWatch as the scientist with the top number of Hot Papers in the world [1].

Professor Chou is the author of Pseudo amino acid composition (PseAAC), used in computational biology for proteomics analysis. Its idea has been recently extended for genome analysis as well. He is also the author of Chou's distorted key theory for peptide drugs and Chou's invariance theorem. In 1972 he and his co-workers, by taking into account the spatial factor and force field factor between the enzyme and its substrate, have reported that the upper limit of Diffusion-controlled reaction of enzyme or Diffusion limited enzyme is one order of magnitude higher than the traditional estimation, and can be used to elucidate some surprisingly high reaction rates in molecular biology. In 1979, he introduced four rules in graph theory in enzymatic kinetics, of which Rules 1-3 are for the steady state enzyme-catalyzed systems, and Rule 4 is for the non-steady state ones. In 1977, he predicted the existence of low-frequency phonons in proteins, followed by developing the theory of Low-frequency collective motion in proteins and DNA after it had been confirmed by Raman spectroscopy.

Education and career

After earning a BS in Physics (1960) and MS in Theoretical Physics (1962) from Nanjing University, Chou joined Shanghai Institute of Biochemistry (now Shanghai Institute of Biochemistry and Cell Biology), Chinese Academy of Sciences, as a junior scientist. He worked with diffusion-controlled reaction of enzymes, low-frequency collective motion in proteins and DNA, and graph theory in enzymatic kinetics while studying for a Ph.D. He was then promoted by the Chinese Academy of Sciences directly to Associate Professor.

In 1979-1980, he was invited by Professor Sture Forsén and Professor Manfred Eigen, respectively, to work in the Chemical Center of Lund University in Sweden and Max Planck Institute for Biophysical Chemistry at Göttingen of Germany as a Visiting Professor. From 1981, he was invited by Professor Harold Scheraga to work in the Baker Laboratory of Chemistry, Cornell University in the USA as a visiting Professor. In 1986, he joined Upjohn then Pharmacia & Upjohn, and then Pfizer as a senior principal investigator.

Publications

Chou has published over 580 papers in the fields of computational biology and biomedicine, protein structure prediction, low-frequency internal motion of protein/DNA molecules and its biological functions, diffusion-controlled reactions of enzymes, as well as graphic rules in enzyme kinetics and other biological systems.

Awards and honors

Chou’s awards and honors include the “Medal of Science and Technology” (Shanghai Congress of Science & Technology, 1977); “National Science Medal” (Chinese Academy of Sciences, China, 1978); Doctor of Science for the work on “Low-Frequency Motions of Protein Molecules” (Kyoto University, Japan, March 6, 1985); and “The Scientist with the most hot papers (2007-2008) in the world".

One of his papers was named a ScienceWatch New Hot Paper in the field of biology and biochemistry. He was named a "high impact distinguished professor” (King Abdulaziz University, 2013) and received a "First-Class Science & Technology Award" from the Shanghai Municipal People’s Government, 2015).

He was Honorary Chair of the 7th International Conference on Bioinformatics (October 24–25, 2016 Rome, Italy). He was named a Highly Cited Researcher in 2014, 2015, 2016 and 2017.

• For the most updated and reliable information about Prof. Dr. Kuo-Chen Chou, please click https://gordonlifescience.org/ or open the PDF file for the paper “The Development of Gordon Life Science Institute: Its Driving Force and Accomplishments”.

  

  Summary of Gordon Life Science Mission and Achievements

References

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