Lineage B.1.618
Lineage B.1.618 is a genetic lineage of SARS-CoV-2 identified from India.[1]. The lineage has been one of the most sequenced lineages in the state of West Bengal in India[2]. It has also been widely called the 'triple mutant' or the 'Bengal strain'[3], both of which are misnomers[4]. The lineage is now present in a number of countries across the world[5]
The lineage was widely reported from a tweet by Indian scientist Vinod Scaria[6] on April 20, 2021, who described the characteristic features as well as discriminating variants.
Characteristics
The lineage is characterized by an E484K mutation[7] in the Spike protein of SARS-CoV-2, which is shared with the B.1.351 lineage of the virus and also associated with immune escape as per the data cataloged in the SARS-CoV-2 Immune escape variant database[8]. Additionally, the lineage harbors a genetic deletion encompassing H146 and Y145 amino acids of the spike protein[9]
Immune Escape
While the E484K mutation in the spike protein has been associated with immune escape, no cases of reinfections or vaccine breakthrough infections have been reported to date.
References
- ↑ Basu, Mohana (2021-04-20). "New Covid lineage B.1.618 identified from Bengal, 2nd in India after 'double mutant' virus". ThePrint. Retrieved 2021-04-26.
- ↑ "New B.1.618 variants now among most sequenced". Hindustan Times. 2021-04-21. Retrieved 2021-04-26.
- ↑ Apr 22, Subhro Niyogi / TNN / Updated; 2021; Ist, 20:22. "Triple mutant strain in West Bengal: Triple-mutant 'Bengal strain' a new worry in second wave | Kolkata News - Times of India". The Times of India. Retrieved 2021-04-26.
- ↑ Sandhya Ramesh (2021-04-23). "'Double mutant, triple mutant, Bengal lineage' — Covid variants driving India surge decoded". ThePrint. Retrieved 2021-04-26.
- ↑ "outbreak.info". outbreak.info. Retrieved 2021-04-26.
- ↑ "https://twitter.com/vinodscaria/status/1384375736643952640". Twitter. Retrieved 2021-04-26. External link in
|title=(help) - ↑ DelhiApril 22, India Today Web Desk New; April 23, 2021UPDATED; Ist, 2021 07:34. "What is the new 'triple mutant variant' of Covid-19 virus found in Bengal? How bad is it?". India Today. Retrieved 2021-04-26.
- ↑ "ESC - Comprehensive Resource for Immune Escape Variants in SARS-CoV-2 | CSIR Institute of Genomics & Integrative Biology (CSIR-IGIB)". ESC - Comprehensive Resource for Immune Escape Variants in SARS-CoV-2 | CSIR Institute of Genomics & Integrative Biology (CSIR-IGIB). Retrieved 2021-04-26.
- ↑ Sandhya Ramesh (2021-04-23). "'Double mutant, triple mutant, Bengal lineage' — Covid variants driving India surge decoded". ThePrint. Retrieved 2021-04-26.
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