Lipid fingerprint
Lipid fingerprints are unique lipid distributions around membrane proteins. They were first introduced by Siewert Marrink and Peter Tieleman et al., who used molecular dynamics to map the unique lipid distributions around numerous membrane proteins in a complex model lipid environment.[1]. The concept rapidly gained popularity among membrane biologists and is generally considered to have superseded the concept of a lipid annulus around a membrane protein. It has been argued that lipid fingerprints are a fundamental aspect of a giant protein-lipid code that functionalizes membranes[2].
Features
Lipid fingerprints include lipids that are both tightly bound to the surface of a protein as well as those that are more loosely associated and those that are more distant. Importantly, since every protein has a unique structure, each lipid fingerprint is also unique. It has been suggested that lipid fingerprints play a role in controlling the clustering of membrane proteins. Since biological membranes contain many different lipids, it is expected that a lipid fingerprint is very complex and typically involves a great variety of lipids. Lipids that do not belong to a fingerprint have been termed void zone, and together fingerprint zones and void zones comprise all membrane lipids[3][4].
Notable examples
The mechanosensitive channel Piezo2 has a complex lipid fingerprint that tends to include phosphoinositide lipids with long residency times[5]. The notable cancer target KRas's lipid fingerprint is highly sensitive to its conformational state[6]
References
- ↑ Corradi, Valentina; Mendez-Villuendas, Eduardo; Ingólfsson, Helgi I.; Gu, Ruo-Xu; Siuda, Iwona; Melo, Manuel N.; Moussatova, Anastassiia; DeGagné, Lucien J.; Sejdiu, Besian I.; Singh, Gurpreet; Wassenaar, Tsjerk A.; Delgado Magnero, Karelia; Marrink, Siewert J.; Tieleman, D. Peter (27 June 2018). "Lipid–Protein Interactions Are Unique Fingerprints for Membrane Proteins". ACS Central Science. 4 (6): 709–717. doi:10.1021/acscentsci.8b00143. PMC 6028153. PMID 29974066.
- ↑ Kervin, Troy A.; Overduin, Michael (27 February 2024). "Membranes are functionalized by a proteolipid code". BMC Biology. 22 (1). doi:10.1186/s12915-024-01849-6. PMC 10898092 Check
|pmc=value (help). PMID 38414038 Check|pmid=value (help). Unknown parameter|article-number=ignored (help) - ↑ Mioka, Tetsuo; Guo, Tian; Wang, Shiyao; Tsuji, Takuma; Kishimoto, Takuma; Fujimoto, Toyoshi; Tanaka, Kazuma (1 March 2022). "Characterization of micron-scale protein-depleted plasma membrane domains in phosphatidylserine-deficient yeast cells". Journal of Cell Science. 135 (5). doi:10.1242/jcs.256529. PMID 34000034 Check
|pmid=value (help). Unknown parameter|article-number=ignored (help) - ↑ Overduin, Michael; Bhat, Rakesh; Dieudonné, Thibaud; Zhang, Peijun; Kervin, Troy A. (1 June 2025). "Deciphering the language of mingling lipids and proteins". Current Opinion in Structural Biology. 92. doi:10.1016/j.sbi.2025.103061. PMID 40339327 Check
|pmid=value (help). Unknown parameter|article-number=ignored (help) - ↑ Lin, Yiechang; Buyan, Amanda; Corry, Ben (21 July 2022). "Characterizing the lipid fingerprint of the mechanosensitive channel Piezo2". Journal of General Physiology. 154 (10). doi:10.1085/jgp.202113064. PMC 9532583 Check
|pmc=value (help). PMID 35861699 Check|pmid=value (help). Unknown parameter|article-number=ignored (help) - ↑ Shrestha, Rebika; Carpenter, Timothy S.; Van, Que N.; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N.; López, Cesar A.; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K.; Ingólfsson, Helgi I.; Lightstone, Felice C.; Stephen, Andrew G.; Streitz, Frederick H.; Nissley, Dwight V.; Turbyville, Thomas J. (28 February 2024). "Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane". Communications Biology. 7 (1). doi:10.1038/s42003-024-05916-0. PMC 10902389 Check
|pmc=value (help). PMID 38418613 Check|pmid=value (help). Unknown parameter|article-number=ignored (help)
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