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Marc E. Rothenberg

From EverybodyWiki Bios & Wiki






Marc E. Rothenberg
Born1961
Forest Hills, NY
🏫 EducationBrandeis University; Harvard Medical School
💼 Occupation
TitleProfessor of Pediatrics;

Director, Division of Allergy and Immunology at Cincinnati Children's Hospital Medical Center;

Director, Cincinnati Center for Eosinophilic Disorders


Marc E. Rothenberg, MD, PhD is an American Physician-Scientist and Professor of Pediatrics. He is the Founder and Director of the Division of Allergy and Immunology at Cincinnati Children’s Hospital Medical Center (CCHMC) and a tenured Professor of Pediatrics at the University of Cincinnati College of Medicine (UCCOM). Rothenberg's research has elucidated fundamental mechanisms involved in allergies, particularly focused on eosinophils and control of their expansion. His research paved the way for the new class of asthma medicines (anti-eosinophil therapies), which are now being applied to other diseases such as hypereosinophilic syndrome and eosinophilic gastrointestinal diseases (EGID). His pioneering research has led to the recognition of EGID as a separate disease entity, with a special interest in understanding the genetic, cellular, and molecular basis for eosinophilic esophagitis (EoE).

Career

Rothenberg graduated summa cum laude with Highest Honors in Chemistry and Biochemistry from Brandeis University. His research at Brandeis University was conducted under the mentorship of Professor William P. Jencks, MD, a pioneer in biochemistry and enzymology. At Harvard Medical School (HMS), he completed the combined MD/PhD program. His PhD, under the mentorship of Professor K. Frank Austen, included seminal studies on eosinophil hematopoiesis, identifying and characterizing the original biology of eosinophilopoetins, which helped lead to the development of a new class of FDA drugs (humanized anti–IL-5). Dr. Rothenberg completed a pediatric residency and combined fellowship in Allergy/Immunology and Hematology at Children’s Hospital in Boston. His postdoctoral training was completed in the genetics laboratory of Professor Philip Leder, MD at HMS, where he cloned the eotaxin chemokine, resulting in a new direction in allergy research. He came to the University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center in 1996 and has helped build a renowned program in pediatric research.

In 2001, Rothenberg established the Cincinnati Center for Eosinophilic Disorders (CCED), the first center solely focused on eosinophilic diseases. The CCED serves as a model and is exemplary to other centers formed around the world. Rothenberg also founded and is the current Director of the NIH-sponsored Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) involving 16 clinical and research centers in the USA and part of the Rare Diseases Clinical Research Network (RDCRN), led by the National Center for Advancing Translational Sciences [NCATS] through its Office of Rare Diseases Research [ORDR] of the NIH. CEGIR’s mission is to improve the lives of those suffering from eosinophilic gastrointestinal disorders. EGIDExpress is the data-sharing platform for researchers to view published datasets generated by the Rothenberg CURED Laboratory.

Rothenberg is certified by the National Board of Medical Examiners; Board of Registration in Medicine, MA; American Board of Pediatrics; Ohio State Medical Board; and the American Board of Allergy and Immunology.

Research

Rothenberg leads the Rothenberg CURED Laboratory at Cincinnati Children's Hospital Medical Center in conducting basic, translational, and clinical research. Rothenberg's research focuses on the molecular analysis of allergic inflammation, primarily on the pathogenesis of eosinophilic gastrointestinal disorders (EGIDs). His laboratory takes multidisciplinary approaches including the development of preclinical murine models of allergic disease, genetics, genomics, molecular immunology, cellular biology, and biochemistry.

Rothenberg has elucidated the pathways that control eosinophilia, involving the eosinophilopoeitin IL-5 and the eotaxin family of chemoattractants, and propelled the development of a new class of drugs including conducting proof-of-principle studies in humans. He defined the role of T cell derived IL-13, the disrupted epithelial barrier elicited by imbalanced proteases/anti-proteases, and microRNAs in eliciting allergic esophagitis. His findings have provided the basis for molecular diagnostics and precision therapy in the allergy field such as the eosinophilic esophagitis diagnostic panel (EDP).[1]

Rothenberg is an international speaker, most often for his work on Mechanisms of Allergy and Eosinophilic Esophagitis (EoE).

Awards and Honors

Rothenberg’s awards include the 2007 E. Mead Johnson Award from the Society of Pediatric Research and an NIH MERIT Award in 2010, and he was recognized as a Highly Cited (top 1%) Researcher for 2018 (Clarivate Analytics). He is an elected member of the American Society of Clinical Investigation, American Academy of Pediatrics, American Association for the Advancement of Science, Society for Pediatric Research, and Hewlett-Woodmere Alumni Hall of Fame. Rothenberg's publications number over 400. He is an Associate Editor of the Journal of Allergy and Clinical Immunology and an Editorial Advisor for the Journal of Clinical Investigation and co-Section Head of the Allergy and Hypersensitivity Section of Faculty 1000. He has served a four-year term on the Advisory Council of the NIAID, during which the council advised NIAID Director Anthony Fauci on the allocation and prioritization of its $4 billion annual budget. Rothenberg's research has been supported by numerous sources including the NIH, Human Frontier Science Program Organization, Burroughs Wellcome Fund, Dana Foundation, [United States Department of Defense], US-Israel Binational Fund, and Patient-Centered Outcomes Research Institute. He has trained over 100 clinical and research investigators in his laboratory and also as Program Director and/or Co-Principal Investigator of several NIH training grants.

Selected Publications

[2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26]

References

Rothenberg Complete List of Published Work in NIH MyBibliography <ref>Rothenberg, Marc (2008). "2007 E. Mead Johnson award: scientific pursuit of the allergy problem". Pediatric Research. 1 (64): 110–5. doi:10.1203/PDR.0b013e3181794507. PMID 18414146. Unknown parameter |s2cid= ignored (help)</ref

  1. ↑ Wen, T; Stucke, EM; Grotjan, TM; Kemme, KA; Abonia, JP; Putnam, PE; Franciosi, JP; Garza, JM; Kaul, A; King, EC; Collins, MH; Kushner, JP; Rothenberg, ME (December 2013). "Molecular diagnosis of eosinophilic esophagitis by gene expression profiling". Gastroenterology. 145 (6): 1289–99. doi:10.1053/j.gastro.2013.08.046. PMC 4070519. PMID 23978633.
  2. ↑ Rothenberg, ME (July 2008). "2007 E. Mead Johnson award: scientific pursuit of the allergy problem". Pediatric Research. 64 (1): 110–5. doi:10.1203/PDR.0b013e3181794507. PMID 18414146. Unknown parameter |s2cid= ignored (help)
  3. ↑ Azouz, NP; Klingler, AM; Pathre, P; Besse, JA; Baruch-Morgenstern, NB; Ballaban, AY; Osswald, GA; Brusilovsky, M; Habel, JE; Caldwell, JM; Ynga-Durand, MA; Abonia, PJ; Hu, YC; Wen, T; Rothenberg, ME (27 May 2020). "Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis". Science Translational Medicine. 12 (545): eaaz7773. doi:10.1126/scitranslmed.aaz7773. PMC 7350155 Check |pmc= value (help). PMID 32461336 Check |pmid= value (help).
  4. ↑ Shoda, T; Wen, T; Aceves, SS; Abonia, JP; Atkins, D; Bonis, PA; Caldwell, JM; Capocelli, KE; Carpenter, CL; Collins, MH; Dellon, ES; Eby, MD; Gonsalves, N; Gupta, SK; Falk, GW; Hirano, I; Menard-Katcher, P; Kuhl, JT; Krischer, JP; Leung, J; Mukkada, VA; Spergel, JM; Trimarchi, MP; Yang, GY; Zimmermann, N; Furuta, GT; Rothenberg, ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers, (CEGIR). (July 2018). "Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study". The Lancet. Gastroenterology & Hepatology. 3 (7): 477–488. doi:10.1016/S2468-1253(18)30096-7. PMC 5997568. PMID 29730081.
  5. ↑ Kottyan, LC; Davis, BP; Sherrill, JD; Liu, K; Rochman, M; Kaufman, K; Weirauch, MT; Vaughn, S; Lazaro, S; Rupert, AM; Kohram, M; Stucke, EM; Kemme, KA; Magnusen, A; He, H; Dexheimer, P; Chehade, M; Wood, RA; Pesek, RD; Vickery, BP; Fleischer, DM; Lindbad, R; Sampson, HA; Mukkada, VA; Putnam, PE; Abonia, JP; Martin, LJ; Harley, JB; Rothenberg, ME (August 2014). "Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease". Nature Genetics. 46 (8): 895–900. doi:10.1038/ng.3033. PMC 4121957. PMID 25017104.
  6. ↑ Blanchard, C; Wang, N; Stringer, KF; Mishra, A; Fulkerson, PC; Abonia, JP; Jameson, SC; Kirby, C; Konikoff, MR; Collins, MH; Cohen, MB; Akers, R; Hogan, SP; Assa'ad, AH; Putnam, PE; Aronow, BJ; Rothenberg, ME (February 2006). "Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis". The Journal of Clinical Investigation. 116 (2): 536–47. doi:10.1172/JCI26679. PMC 1359059. PMID 16453027.
  7. ↑ Azouz, NP; Ynga-Durand, MA; Caldwell, JM; Jain, A; Rochman, M; Fischesser, DM; Ray, LM; Bedard, MC; Mingler, MK; Forney, C; Eilerman, M; Kuhl, JT; He, H; Biagini Myers, JM; Mukkada, VA; Putnam, PE; Khurana Hershey, GK; Kottyan, LC; Wen, T; Martin, LJ; Rothenberg, ME (6 June 2018). "The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses". Science Translational Medicine. 10 (444): eaap9736. doi:10.1126/scitranslmed.aap9736. PMC 6065103. PMID 29875205.
  8. ↑ Lu, TX; Munitz, A; Rothenberg, ME (15 April 2009). "MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression". Journal of Immunology. 182 (8): 4994–5002. doi:10.4049/jimmunol.0803560. PMC 4280862. PMID 19342679.
  9. ↑ Rothenberg, ME; Klion, AD; Roufosse, FE; Kahn, JE; Weller, PF; Simon, HU; Schwartz, LB; Rosenwasser, LJ; Ring, J; Griffin, EF; Haig, AE; Frewer, PI; Parkin, JM; Gleich, GJ; Mepolizumab HES Study, Group. (20 March 2008). "Treatment of patients with the hypereosinophilic syndrome with mepolizumab". The New England Journal of Medicine. 358 (12): 1215–28. doi:10.1056/NEJMoa070812. PMID 18344568.
  10. ↑ Hogan, SP; Mishra, A; Brandt, EB; Royalty, MP; Pope, SM; Zimmermann, N; Foster, PS; Rothenberg, ME (April 2001). "A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation". Nature Immunology. 2 (4): 353–60. doi:10.1038/86365. PMID 11276207. Unknown parameter |s2cid= ignored (help)
  11. ↑ Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kc, K; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; Darko, S; Douek, D; Rothenberg, ME (8 April 2019). "Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis". The Journal of Clinical Investigation. 129 (5): 2014–2028. doi:10.1172/JCI125917. PMC 6486341. PMID 30958799.
  12. ↑ Sherrill, JD; Kc, K; Wang, X; Wen, T; Chamberlin, A; Stucke, EM; Collins, MH; Abonia, JP; Peng, Y; Wu, Q; Putnam, PE; Dexheimer, PJ; Aronow, BJ; Kottyan, LC; Kaufman, KM; Harley, JB; Huang, T; Rothenberg, ME (19 April 2018). "Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis". JCI Insight. 3 (8). doi:10.1172/jci.insight.99922. PMC 5931135. PMID 29669943.
  13. ↑ Davis, BP; Stucke, EM; Khorki, ME; Litosh, VA; Rymer, JK; Rochman, M; Travers, J; Kottyan, LC; Rothenberg, ME (April 2016). "Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment". JCI Insight. 1 (4): e86355. doi:10.1172/jci.insight.86355. PMC 4855700. PMID 27158675.
  14. ↑ Munitz, A; McBride, ML; Bernstein, JS; Rothenberg, ME (15 June 2008). "A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils". Blood. 111 (12): 5694–703. doi:10.1182/blood-2007-12-126748. PMC 2964258. PMID 18316626.
  15. ↑ Shoda, T; Wen, T; Caldwell, JM; Collins, MH; Besse, JA; Osswald, GA; Abonia, JP; Arva, NC; Atkins, D; Capocelli, KE; Dellon, ES; Falk, GW; Gonsalves, N; Gupta, SK; Hirano, I; Mukkada, VA; Putnam, PE; Sheridan, RM; Rudman Spergel, AK; Spergel, JM; Wechsler, JB; Yang, GY; Aceves, SS; Furuta, GT; Rothenberg, ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers, (CEGIR). (January 2020). "Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study". The Journal of Allergy and Clinical Immunology. 145 (1): 255–269. doi:10.1016/j.jaci.2019.11.007. PMC 6949389 Check |pmc= value (help). PMID 31738990.
  16. ↑ Kottyan, LC; Davis, BP; Sherrill, JD; Liu, K; Rochman, M; Kaufman, K; Weirauch, MT; Vaughn, S; Lazaro, S; Rupert, AM; Kohram, M; Stucke, EM; Kemme, KA; Magnusen, A; He, H; Dexheimer, P; Chehade, M; Wood, RA; Pesek, RD; Vickery, BP; Fleischer, DM; Lindbad, R; Sampson, HA; Mukkada, VA; Putnam, PE; Abonia, JP; Martin, LJ; Harley, JB; Rothenberg, ME (August 2014). "Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease". Nature Genetics. 46 (8): 895–900. doi:10.1038/ng.3033. PMC 4121957. PMID 25017104.
  17. ↑ Wen, T; Stucke, EM; Grotjan, TM; Kemme, KA; Abonia, JP; Putnam, PE; Franciosi, JP; Garza, JM; Kaul, A; King, EC; Collins, MH; Kushner, JP; Rothenberg, ME (December 2013). "Molecular diagnosis of eosinophilic esophagitis by gene expression profiling". Gastroenterology. 145 (6): 1289–99. doi:10.1053/j.gastro.2013.08.046. PMC 4070519. PMID 23978633.
  18. ↑ Rothenberg, ME; Spergel, JM; Sherrill, JD; Annaiah, K; Martin, LJ; Cianferoni, A; Gober, L; Kim, C; Glessner, J; Frackelton, E; Thomas, K; Blanchard, C; Liacouras, C; Verma, R; Aceves, S; Collins, MH; Brown-Whitehorn, T; Putnam, PE; Franciosi, JP; Chiavacci, RM; Grant, SF; Abonia, JP; Sleiman, PM; Hakonarson, H (April 2010). "Common variants at 5q22 associate with pediatric eosinophilic esophagitis". Nature Genetics. 42 (4): 289–91. doi:10.1038/ng.547. PMC 3740732. PMID 20208534.
  19. ↑ Dunn, JLM; Shoda, T; Caldwell, JM; Wen, T; Aceves, SS; Collins, MH; Dellon, ES; Falk, GW; Leung, J; Martin, LJ; Menard-Katcher, P; Rudman-Spergel, AK; Spergel, JM; Wechsler, JB; Yang, GY; Furuta, GT; Rothenberg, ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers, (CEGIR). (June 2020). "Esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multisite cohort". The Journal of Allergy and Clinical Immunology. 145 (6): 1629–1640.e4. doi:10.1016/j.jaci.2020.01.051. PMC 7309223 Check |pmc= value (help). PMID 32197970 Check |pmid= value (help). Unknown parameter |pmc-embargo-date= ignored (help)
  20. ↑ Gupta, SK; Falk, GW; Aceves, SS; Chehade, M; Collins, MH; Dellon, ES; Gonsalves, N; Hirano, I; Mukkuda, VA; Peterson, KA; Spergel, J; Yang, GY; Furuta, GT; Rothenberg, ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers, (CEGIR). (March 2019). "Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration". Gastroenterology. 156 (4): 838–842. doi:10.1053/j.gastro.2018.10.057. PMID 30452923.
  21. ↑ Rothenberg, ME; Wen, T; Greenberg, A; Alpan, O; Enav, B; Hirano, I; Nadeau, K; Kaiser, S; Peters, T; Perez, A; Jones, I; Arm, JP; Strieter, RM; Sabo, R; Gunawardena, KA (February 2015). "Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis". The Journal of Allergy and Clinical Immunology. 135 (2): 500–7. doi:10.1016/j.jaci.2014.07.049. PMID 25226850.
  22. ↑ Butz, BK; Wen, T; Gleich, GJ; Furuta, GT; Spergel, J; King, E; Kramer, RE; Collins, MH; Stucke, E; Mangeot, C; Jackson, WD; O'Gorman, M; Abonia, JP; Pentiuk, S; Putnam, PE; Rothenberg, ME (August 2014). "Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis". Gastroenterology. 147 (2): 324–33.e5. doi:10.1053/j.gastro.2014.04.019. PMC 4107112. PMID 24768678.
  23. ↑ Rothenberg, ME; Owen WF, Jr; Silberstein, DS; Soberman, RJ; Austen, KF; Stevens, RL (7 August 1987). "Eosinophils cocultured with endothelial cells have increased survival and functional properties". Science. 237 (4815): 645–7. Bibcode:1987Sci...237..645R. doi:10.1126/science.3110954. PMID 3110954.
  24. ↑ Mishra, A; Hogan, SP; Brandt, EB; Rothenberg, ME (January 2001). "An etiological role for aeroallergens and eosinophils in experimental esophagitis". The Journal of Clinical Investigation. 107 (1): 83–90. doi:10.1172/JCI10224. PMC 198543. PMID 11134183.
  25. ↑ Furuta, GT; Liacouras, CA; Collins, MH; Gupta, SK; Justinich, C; Putnam, PE; Bonis, P; Hassall, E; Straumann, A; Rothenberg, ME; First International Gastrointestinal Eosinophil Research Symposium (FIGERS), Subcommittees. (October 2007). "Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment". Gastroenterology. 133 (4): 1342–63. doi:10.1053/j.gastro.2007.08.017. PMID 17919504.
  26. ↑ Azouz, NP; Klingler, AM; Pathre, P; Besse, JA; Baruch-Morgenstern, NB; Ballaban, AY; Osswald, GA; Brusilovsky, M; Habel, JE; Caldwell, JM; Ynga-Durand, MA; Abonia, PJ; Hu, YC; Wen, T; Rothenberg, ME (27 May 2020). "Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis". Science Translational Medicine. 12 (545): eaaz7773. doi:10.1126/scitranslmed.aaz7773. PMC 7350155 Check |pmc= value (help). PMID 32461336 Check |pmid= value (help).

Rothenberg Biography, Cincinnati Children's Hospital Medical Center Rothenberg CURED Laboratory at Cincinnati Children's Hospital Medical Center Cincinnati Children's Hospital Medical Center - Center for Eosinophilic Disorders CEGIR Clarivate Analytics Highly Cited Researchers 2018-Congratulations to Dr Marc Rothenberg! Eosinophilic Disorders | In the News Allergy and Immunology | News, Education and Events Allergy and Immunology


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