Marek Basler
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 File:Marek_Basler, 2026.jpg Marek Basler (2026) | |
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Marek Basler (born 1978 in Opava, Czech Republic) is a Czech Microbiologist and Professor of Infection Biology at the Biozentrum University of Basel, Switzerland.
Biography
Marek Basler studied biochemistry and microbiology at the Institute of Microbiology of the Czech Academy of Sciences in Prague, Czech Republic, and earned his PhD in 2007. Subsequently, he worked as a postdoctoral fellow in the laboratory of Prof. John Mekalanos at the Harvard Medical School in Boston, USA. Since 2013, Basler has been teaching and leading a research group at the Biozentrum of the University of Basel, first as an Assistant Professor and since 2026 as a Full Professor of Infection Biology.
Scientific Career
Marek Basler investigates a bacterial injection apparatus involved in infectious diseases as well as in shaping bacterial communities. The so-called type VI secretion system (T6SS) works like a speargun and is used by many bacteria, including pathogens, to inject a cocktail of toxins into cells.
In recent years, Basler has elucidated key aspects of T6SS function, molecular architecture, and assembly, as well as its widespread use across diverse bacterial species. He showed that certain bacteria localize T6SS assembly to contact sites with neighboring bacteria.[1], and that the intracellular pathogen Burkholderia thailandensis uses this nanomachine to spread within the host.[2] Atomic force microscopy studies further revealed that Pseudomonas aeruginosa assembles its T6SS in response to outer membrane damage. [3] More recently, he identified a trade-off: activation of a general defense program against T6SS attacks increases the bacterium’s sensitivity to antibiotics[4]
Awards & Honors
- 2023 Elected member of the European Molecular Biology Organization (EMBO)
- 2019 ERC Consolidator Grant[5]
- 2018 EMBO Gold Medal[6]
- 2018 Friedrich Miescher Award[7]
- 2015 EMBO Young Investigator[8]
References
- ↑ Lin, Lin; Capozzoli, Raffaella; Ferrand, Alexia; Plum, Miro; Vettiger, Andrea; Basler, Marek (30 May 2022). "Subcellular localization of Type VI secretion system assembly in response to cell–cell contact". The EMBO Journal. 41 (13): EMBJ2021108595. doi:10.15252/embj.2021108595. ISSN 1460-2075. PMC 9251886 Check
|pmc=value (help). PMID 35634969 Check|pmid=value (help).CS1 maint: Date and year (link) - ↑ Tejada-Arranz, Alejandro; Plack, Annika; Antelo-Varela, Minia; Kaczmarczyk, Andreas; Klotz, Alexander; Jenal, Urs; Basler, Marek (28 November 2025). "Mechanisms of Pseudomonas aeruginosa resistance to type VI secretion system attacks". Nature Communications. 16 (1): 10744. Bibcode:2025NatCo..1610744T. doi:10.1038/s41467-025-65777-x. ISSN 2041-1723. PMC 12663445 Check
|pmc=value (help). PMID 41315259 Check|pmid=value (help).CS1 maint: Date and year (link) - ↑ Brüderlin, Mitchell; Kolesnikov, Maxim; Röthlin, Florian; Lim, Roderick Y. H.; Basler, Marek (2026). "Pseudomonas aeruginosa assembles H1-T6SS in response to physical and chemical damage". Science Advances. American Association for the Advancement of Science. 11 (10): eadr1713. doi:10.1126/sciadv.adr1713. PMC 11881912 Check
|pmc=value (help). PMID 40043119 Check|pmid=value (help). - ↑ Tejada-Arranz, Alejandro; Plack, Annika; Antelo-Varela, Minia; Kaczmarczyk, Andreas; Klotz, Alexander; Jenal, Urs; Basler, Marek (28 November 2025). "Mechanisms of Pseudomonas aeruginosa resistance to type VI secretion system attacks". Nature Communications. 16 (1): 10744. Bibcode:2025NatCo..1610744T. doi:10.1038/s41467-025-65777-x. ISSN 2041-1723. PMC 12663445 Check
|pmc=value (help). PMID 41315259 Check|pmid=value (help).CS1 maint: Date and year (link) - ↑ "Marek Basler receives prestigious ERC Consolidator Grant". Retrieved 27 May 2026.
- ↑ "EMBO Gold Medal 2018 awarded to Marek Basler and Melina Schuh". 16 May 2018. Retrieved 27 May 2026.
- ↑ "Friedrich Miescher Award". Retrieved 27 May 2026.
- ↑ "EMBO Young Investigator". Retrieved 27 May 2026.
External links
- Research Group Marek Basler
- Biozentrum University of Basel
- University of Basel
- European Molecular Biology Organization (EMBO)
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