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Matthew H. Todd

From EverybodyWiki Bios & Wiki


Matthew H. Todd
MatMatthew H. Todd.jpg Matthew H. Todd.jpg
Todd at the University of Sydney (2013)
Born (1973-01-13) 13 January 1973 (age 53)
Manchester, United Kingdom
🏡 ResidenceLondon, United Kingdom
🏳️ NationalityBritish
🏳️ CitizenshipUnited Kingdom
🎓 Alma materUniversity of Cambridge
💼 Occupation
Known forOpen Source Malaria
Open Source Tuberculosis
Open Source Mycetoma
🌐 Websitehttps://openwetware.org/wiki/Todd

Matthew Houghton Todd (born 13 January 1973) is a British chemist and the Professor and Chair of Drug Discovery of the School of Pharmacy at University College London.[1] He is best known as the founder of Open Source Malaria (OSM) and his research focuses on drug discovery and development for this disease.[2][3][4][5] Recently, he has expanded to other areas such as mycetoma[6] in the Open Source Mycetoma (MycetOS) project, through a collaboration with the Drugs for Neglected Diseases Initiative and Erasmus MC.[7] In addition, he has some presence in catalysis and methodology.[8][9][10][11]

Education

Todd received an MA in Natural Sciences from the University of Cambridge in 1995. He obtained his PhD in Organic Chemistry at the same institution in 1999, working with Chris Abell on encoding and linker strategies for combinatorial chemistry.[12][13][14][15] Todd was a Wellcome Trust Postdoctoral Research Fellow at the University of California, Berkeley from 1999 to 2000, working with Paul A. Bartlett on synthesis of amino acid-derived heterocycles by Lewis acid catalysis and radical cyclisations from peptide acetals.[16][17]

Career

From 2000 to 2001, he was a College Fellow and Lecturer at New Hall, Cambridge (now Murray Edwards College, Cambridge). He began his independent research career in 2001 at Queen Mary, University of London. In 2005, he relocated to the University of Sydney where he was a Lecturer, Senior Lecturer, then Associate Professor. He has been the Professor and Chair of Drug Discovery at UCL School of Pharmacy since 2018.

In response to the price hike of HIV/AIDS drug, pyrimethamine (Daraprim), by Turing Pharmaceuticals,[18] Todd and the Open Source Malaria team led a small team of high school students from Sydney Grammar School to synthesise the drug.[19][20] His team produced 3.7 grams of Daraprim for $US20, which would sell for between $US35,000 and $US110,000 in the United States based on hiked prices.[21] This received significant media attention and was featured on ABC,[21] BBC,[22] CNN,[23] The Guardian,[20] and Time.[24]

Todd has been a vocal proponent of open science and open research.[2][5][25][26][27][28] In 2011, he proposed Six Laws of Open Research to guide present and future open research projects including OSM and MycetOS:[5][29][30]

"The Six Laws of Open Research are:[5][31][32]

  1. All data are open and all ideas are shared.
  2. Anyone can take part at any level of the project.
  3. There will be no patents.
  4. Suggestions are the best form of criticism.
  5. Public discussion is much more valuable than private email.
  6. The project is bigger than, and is not owned by, any given lab. The aim is to find a good drug for malaria, by whatever means, as quickly as possible."

Todd is on the Editorial Boards of Chemistry Central Journal,[33] ChemistryOpen,[34] PLOS One,[35] Scientific Reports,[36] and Scientific Data.[37]

Honors and Awards

  • 2017-2018 - Medicine Maker Power List[38][39]
  • 2012 - Wellcome Trust/Google/PLOS Accelerating Science Award[40]
  • 2011 - NSW Premier's Prize for Science & Engineering (Emerging Research)[41]

See also

References

  1. ↑ "Professor Matthew Todd - UCL School of Pharmacy". Archived from the original on 2020-09-03. Retrieved 2019-03-02.
  2. ↑ 2.0 2.1 Peplow, M (2019). "Open-source drug discovery takes aim at malaria and neglected diseases". C&EN. ACS. Retrieved 13 February 2019.
  3. ↑ Lowe, D. "The Open Source Malaria Project, So Far". In The Pipeline. Science. Retrieved 13 February 2019.
  4. ↑ Williamson, AE (2016). "Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles". ACS Central Science. 2 (10): 687–701. doi:10.1021/acscentsci.6b00086. Retrieved 12 February 2019.
  5. ↑ 5.0 5.1 5.2 5.3 Robertson, MN (2014). "Open source drug discovery – A limited tutorial". Parasitology. 141 (1): 148–157. doi:10.1017/S0031182013001121.
  6. ↑ Lim, W (2018). "Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma". PLOS Neglected Tropical Diseases. 12 (2): e0006437. doi:10.1371/journal.pntd.0006437.
  7. ↑ "MycetOS – DNDi".
  8. ↑ Park, SJ (2002). "Oxidative Arylation of Isochroman". Journal of Organic Chemistry. 77 (2): 949–955. doi:10.1021/jo2021373. Retrieved 12 February 2019.
  9. ↑ Tsang, ASK (2009). "Facile synthesis of vicinal diamines via oxidation of N-phenyltetrahydroisoquinolines with DDQ". Tetrahedron Letters. 50 (11): 1199–1202. doi:10.1016/j.tetlet.2008.12.101.
  10. ↑ Hashmi, ASK (2010). "Gold-Catalysis: Reactions of Organogold Compounds with Electrophiles". Australian Journal of Chemistry. 63 (12): 1619–1626. doi:10.1071/CH10342.
  11. ↑ Ahamed, M (2010). "Catalytic Asymmetric Additions of Carbon‐Centered Nucleophiles to Nitrogen‐Containing Aromatic Heterocycles". European Journal of Organic Chemistry. 2010 (31): 5935–5942. doi:10.1002/ejoc.201000877.
  12. ↑ Todd, MH (1997). "Studies on the synthesis, characterisation and reactivity of aromatic diboronic acids". Tetrahedron Letters. 38 (38): 6781–6784. doi:10.1016/S0040-4039(97)01552-9.
  13. ↑ Todd, MH (2001). "Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and Fourier transform ion cyclotron resonance mass spectrometry". Journal of Combinatorial Chemistry. 3 (3): 319–327. doi:10.1021/cc000112m.
  14. ↑ Todd, MH (1999). "A novel safety-catch linker for the solid-phase synthesis of amides and esters". Organic Letters. 1 (8): 1149–1151. doi:10.1021/ol990785h.
  15. ↑ "Past Members - The Abell Group". Archived from the original on 22 September 2020. Retrieved 12 February 2019.
  16. ↑ Todd, MH (2002). "Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals". Journal of Organic Chemistry. 67 (12): 3985–3988. doi:10.1021/jo010990m.
  17. ↑ "Paul A. Bartlett Group Alumni". Retrieved 12 February 2019.
  18. ↑ Timmerman, L. "A Timeline of the Turing Pharma Controversy". Forbes. Retrieved 12 February 2019.
  19. ↑ Reiner, V (30 November 2016). "Students make $750 drug cheaply with Open Source Malaria team". University of Sydney. Retrieved 13 February 2019.
  20. ↑ 20.0 20.1 Davey, M. "Australian students recreate Martin Shkreli price-hike drug in school lab". The Guardian. Retrieved 12 February 2019.
  21. ↑ 21.0 21.1 Hunjan, R. ""Daraprim drug's key ingredient recreated by high school students in Sydney for just $20"". ABC. Retrieved 12 February 2019.
  22. ↑ Dunlop, G. "Martin Shkreli: Australian boys recreate life-saving drug". BBC. Retrieved 12 February 2019.
  23. ↑ Roberts, E. "'Pharma Bro' Martin Shkreli meets his match in a group of Australian schoolboys". CNN. Retrieved 12 February 2019.
  24. ↑ Lui, K. "Watch Martin Shkreli Respond to the School Kids Who Recreated His Drug for $2 a Dose". Time.
  25. ↑ Woelfle, M (2011). "Open science is a research accelerator". Nature Chemistry. 3: 745–748. doi:10.1038/nchem.1149. Retrieved 13 February 2019.
  26. ↑ Laursen, L (2016). "Tropical disease: A neglected cause". Nature. 533 (7602): S68–S69. doi:10.1038/533S68a.
  27. ↑ Anderson, T (2016). "Can open-source drug development deliver?". The Lancet. 387 (10032): 1983–1984. doi:10.1016/S0140-6736(16)30518-9.
  28. ↑ Todd, MH. "Why open source pharma is the path to both new and cheaper medicines". The Guardian. Retrieved 12 February 2019.
  29. ↑ Todd, MH. "Open Source Drug Discovery for Malaria". Retrieved 12 February 2019.
  30. ↑ Pearce, R. "Researchers look to open source to tackle deadly infection". Retrieved 12 February 2019.
  31. ↑ "Open Source Research - OpenWetWare". Retrieved 12 February 2019.
  32. ↑ Williamson, AE. "Open science: the future of research?". ABC. Retrieved 12 February 2019.
  33. ↑ "Chemistry Central Journal (Editorial Board)". Chemistry Central Journal. Archived from the original on 21 June 2018. Retrieved 12 February 2019.
  34. ↑ "Editorial Advisory Board". ChemistryOpen. Retrieved 12 February 2019.
  35. ↑ "Editorial Board". PLOS ONE. Retrieved 12 February 2019.
  36. ↑ "Editorial Advisory Panel and Editorial Board". Scientific Reports. Retrieved 12 February 2019.
  37. ↑ "Editors, Advisory Panel & Editorial Board". Scientific Data. Retrieved 12 February 2019.
  38. ↑ "The Power List 2017". The Medicine Maker.
  39. ↑ "The Power List 2018". The Medicine Maker.
  40. ↑ "ANNOUNCING THE RECIPIENTS FOR THE ACCELERATING SCIENCE AWARD PROGRAM". The Official PLOS Blog.
  41. ↑ "Honour Roll - NSW Chief Scientist & Engineer". NSW Chief Scientist & Engineer. Archived from the original on 2020-08-14. Retrieved 2019-03-02.

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