McN-4187
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| ChemSpider | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}} |
| Chemical and physical data | |
| Formula | C18H23NO2 |
| Molar mass | 285.387 g·mol−1 |
| 3D model (JSmol) | |
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McN-4187 is a synthetic research compound of the 2,2-diarylethylamine class that has been investigated for its potential antidepressant properties. Structurally, it is classified as a benzhydryl-containing compound. McN-4187 was discovered in the 1980s by Bruce E. Maryanoff at McNeil.[1][2] In preclinical studies, McN-4187 exhibited notable potency, particularly in the tetrabenazine (TBZ) model, with effective dose (ED50) values of 15 mg/kg for exploratory behavior and 1.5 mg/kg for ptosis.[1] Structural modifications to McN-4187 substantially diminished its antidepressant activity, underscoring the critical role of its bisethanol moiety and diaryl core in maintaining pharmacological efficacy.[1]
References
- ↑ 1.0 1.1 1.2 Maryanoff BE, Nortey SO, Gardocki JF (August 1984). "Structure-activity studies on antidepressant 2,2-diarylethylamines". Journal of Medicinal Chemistry. 27 (8): 1067–71. doi:10.1021/jm00374a022. PMID 6747990.
- ↑ US 4649204, Maryanoff BE, "Dialkanolamine derivatives", issued 1987, assigned to McNeilab Inc.
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